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Q8EXA4

- PYRF_LEPIN

UniProt

Q8EXA4 - PYRF_LEPIN

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
pyrF, LB_310
Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei101 – 1011Proton donor By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciLINT189518:GJBB-3705-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:LB_310
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001408: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Orotidine 5'-phosphate decarboxylaseUniRule annotationPRO_0000134627Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi189518.LB310.

Structurei

3D structure databases

ProteinModelPortaliQ8EXA4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245747.
KOiK01591.
OMAiCRTSNAG.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8EXA4-1 [UniParc]FASTAAdd to Basket

« Hide

MGGKMNFQSK FLTRSQSLKS LLCVGLDPDF DKLPEIVKRS PEPLVQFCKE    50
IIDATASYAV AYKPNIAFFE VFGSSGIRQF EKVIGHLKSN YPQIPIVADV 100
KRGDLDNTAR QYAKYYFGDL QVDSLTLSPY MGLDSIRPFL EYQDYLIFWL 150
CLTSNPDSAQ FQKKRFSETG RTLYEEVVYV ANLVAISNLG FVVGATSPSE 200
LETLRTQNPN RIFLIPGFGA QGAKLENLLP VCGRNSLINS SRGIHFASNG 250
SDFAVRAGQE AEKIHKMMQT HFIGL 275
Length:275
Mass (Da):30,747
Last modified:March 1, 2003 - v1
Checksum:i882C2B03CFD9A4DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010301 Genomic DNA. Translation: AAN51869.1.
RefSeqiNP_714854.1. NC_004343.2.

Genome annotation databases

EnsemblBacteriaiAAN51869; AAN51869; LB_310.
GeneIDi1153869.
KEGGilil:LB_310.
PATRICi22390160. VBILepInt91350_4631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010301 Genomic DNA. Translation: AAN51869.1 .
RefSeqi NP_714854.1. NC_004343.2.

3D structure databases

ProteinModelPortali Q8EXA4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189518.LB310.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN51869 ; AAN51869 ; LB_310 .
GeneIDi 1153869.
KEGGi lil:LB_310.
PATRICi 22390160. VBILepInt91350_4631.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245747.
KOi K01591.
OMAi CRTSNAG.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci LINT189518:GJBB-3705-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 56601.

Entry informationi

Entry nameiPYRF_LEPIN
AccessioniPrimary (citable) accession number: Q8EXA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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