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Q8EXA4 (PYRF_LEPIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:LB_310
OrganismLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) [Reference proteome] [HAMAP]
Taxonomic identifier189518 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01215
PRO_0000134627

Sites

Active site1011Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8EXA4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 882C2B03CFD9A4DC

FASTA27530,747
        10         20         30         40         50         60 
MGGKMNFQSK FLTRSQSLKS LLCVGLDPDF DKLPEIVKRS PEPLVQFCKE IIDATASYAV 

        70         80         90        100        110        120 
AYKPNIAFFE VFGSSGIRQF EKVIGHLKSN YPQIPIVADV KRGDLDNTAR QYAKYYFGDL 

       130        140        150        160        170        180 
QVDSLTLSPY MGLDSIRPFL EYQDYLIFWL CLTSNPDSAQ FQKKRFSETG RTLYEEVVYV 

       190        200        210        220        230        240 
ANLVAISNLG FVVGATSPSE LETLRTQNPN RIFLIPGFGA QGAKLENLLP VCGRNSLINS 

       250        260        270 
SRGIHFASNG SDFAVRAGQE AEKIHKMMQT HFIGL 

« Hide

References

[1]"Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing."
Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H. expand/collapse author list , Yin H.-F., Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.
Nature 422:888-893(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 56601.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE010301 Genomic DNA. Translation: AAN51869.1.
RefSeqNP_714854.1. NC_004343.2.

3D structure databases

ProteinModelPortalQ8EXA4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING189518.LB310.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN51869; AAN51869; LB_310.
GeneID1153869.
KEGGlil:LB_310.
PATRIC22390160. VBILepInt91350_4631.

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000245747.
KOK01591.
OMACRTSNAG.
OrthoDBEOG6DZF33.

Enzyme and pathway databases

BioCycLINT189518:GJBB-3705-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01215. OMPdecase_type2.
InterProIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02127. pyrF_sub2. 1 hit.
ProtoNetSearch...

Entry information

Entry namePYRF_LEPIN
AccessionPrimary (citable) accession number: Q8EXA4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways