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Protein

Alanine racemase

Gene

alr

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei48Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei144SubstrateUniRule annotation1
Active sitei281Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei329Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciLINT189518:G1GL4-3701-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:LB_317
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000001408 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001145311 – 389Alanine racemaseAdd BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ8EX97

Interactioni

Protein-protein interaction databases

STRINGi189518.LB_317

Structurei

3D structure databases

ProteinModelPortaliQ8EX97
SMRiQ8EX97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
InParanoidiQ8EX97
KOiK01775
OMAiWRGPILL

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8EX97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDINSGSSS MKDTYSSWIE ISKRSLSNNL DNFRSILRPN STLTAILKSN
60 70 80 90 100
AYGHGIEPMT RLCIEAGISR IGVNSIEEAL LIRNIDSKIP ILIMGEIQNP
110 120 130 140 150
EKRKDVLSDP NFWIVFSRPE TARILSSFLP APKLHLKIDT GMGRLGSHGE
160 170 180 190 200
TLKQTLSELK NVGITLGGIC THFASTEDVL EHKYSLMQTQ KFEEAIFLAK
210 220 230 240 250
SFGYNHLIRH ACASASTMLF PNAHFDMVRI GISLYGLWPS IQTRLSLNLT
260 270 280 290 300
GNKNFQLNPI LSWKSRIVHI QYHPADSYIG YGSTFQTSYP TKVAIVPVGY
310 320 330 340 350
YEGLDRKLSS NGDMLVLGKK ARIIGRICMN MTMLDVTHIP GAEVGSIVTI
360 370 380
IGQDGEESIT ADDLADRTHT INYEVMTRIS ESIPRIVVD
Length:389
Mass (Da):43,278
Last modified:March 1, 2003 - v1
Checksum:iB44569674B85B3BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010301 Genomic DNA Translation: AAN51876.1
RefSeqiNP_714861.1, NC_004343.2
WP_001152323.1, NC_004343.2

Genome annotation databases

EnsemblBacteriaiAAN51876; AAN51876; LB_317
GeneIDi1153876
KEGGilil:LB_317
PATRICifig|189518.3.peg.4636

Similar proteinsi

Entry informationi

Entry nameiALR_LEPIN
AccessioniPrimary (citable) accession number: Q8EX97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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