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Q8EWB6

- TRMB_MYCPE

UniProt

Q8EWB6 - TRMB_MYCPE

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, MYPE2880
Organism
Mycoplasma penetrans (strain HF-2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461S-adenosyl-L-methionine By similarity
Binding sitei71 – 711S-adenosyl-L-methionine By similarity
Binding sitei100 – 1001S-adenosyl-L-methionine By similarity
Active sitei122 – 1221 By similarity
Binding sitei122 – 1221S-adenosyl-L-methionine By similarity
Binding sitei126 – 1261Substrate By similarity
Binding sitei158 – 1581Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMPEN272633:GJBP-300-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:MYPE2880
    OrganismiMycoplasma penetrans (strain HF-2)
    Taxonomic identifieri272633 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000002522: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000171358Add
    BLAST

    Proteomic databases

    PRIDEiQ8EWB6.

    Interactioni

    Protein-protein interaction databases

    STRINGi272633.MYPE2880.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8EWB6.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni196 – 1994Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000251689.
    KOiK03439.
    OMAiDNVMTEY.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8EWB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRLRKDYQD ELRLFNSQEF YVLNPNQYKG LWNQQIFKNN NNIEIEVGTG    50
    KGTFIFNKAL KNKNINFIAI DKYPTILAKL LNKLESCSET LTNIKIISID 100
    AKNINDIFDK SEISKIYLNF VDPWPKTHHE KFRLTNSFYL NLFLPLLKQD 150
    GLIEFKTDNL NFFNYSLSVA RENSFCLTFA TKNLYSSAHA KDNIQTEYER 200
    KWSNRGYKIN KLVIKNNISQ 220
    Length:220
    Mass (Da):25,889
    Last modified:March 1, 2003 - v1
    Checksum:iFFA0D7E5F19DA310
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000026 Genomic DNA. Translation: BAC44080.1.
    RefSeqiNP_757676.1. NC_004432.1.

    Genome annotation databases

    EnsemblBacteriaiBAC44080; BAC44080; BAC44080.
    GeneIDi1040935.
    KEGGimpe:MYPE2880.
    PATRICi20019699. VBIMycPen56664_0302.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000026 Genomic DNA. Translation: BAC44080.1 .
    RefSeqi NP_757676.1. NC_004432.1.

    3D structure databases

    ProteinModelPortali Q8EWB6.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 272633.MYPE2880.

    Proteomic databases

    PRIDEi Q8EWB6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC44080 ; BAC44080 ; BAC44080 .
    GeneIDi 1040935.
    KEGGi mpe:MYPE2880.
    PATRICi 20019699. VBIMycPen56664_0302.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000251689.
    KOi K03439.
    OMAi DNVMTEY.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci MPEN272633:GJBP-300-MONOMER.

    Family and domain databases

    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans."
      Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K., Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.
      Nucleic Acids Res. 30:5293-5300(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HF-2.

    Entry informationi

    Entry nameiTRMB_MYCPE
    AccessioniPrimary (citable) accession number: Q8EWB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: March 1, 2003
    Last modified: June 11, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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