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Q8EWB6

- TRMB_MYCPE

UniProt

Q8EWB6 - TRMB_MYCPE

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Mycoplasma penetrans (strain HF-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei46 – 461S-adenosyl-L-methionineUniRule annotation
    Binding sitei71 – 711S-adenosyl-L-methionineUniRule annotation
    Binding sitei100 – 1001S-adenosyl-L-methionineUniRule annotation
    Active sitei122 – 1221By similarity
    Binding sitei122 – 1221S-adenosyl-L-methionineUniRule annotation
    Binding sitei126 – 1261SubstrateUniRule annotation
    Binding sitei158 – 1581SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMPEN272633:GJBP-300-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:MYPE2880
    OrganismiMycoplasma penetrans (strain HF-2)
    Taxonomic identifieri272633 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000002522: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220tRNA (guanine-N(7)-)-methyltransferasePRO_0000171358Add
    BLAST

    Proteomic databases

    PRIDEiQ8EWB6.

    Interactioni

    Protein-protein interaction databases

    STRINGi272633.MYPE2880.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8EWB6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni196 – 1994Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000251689.
    KOiK03439.
    OMAiDNVMTEY.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8EWB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRLRKDYQD ELRLFNSQEF YVLNPNQYKG LWNQQIFKNN NNIEIEVGTG    50
    KGTFIFNKAL KNKNINFIAI DKYPTILAKL LNKLESCSET LTNIKIISID 100
    AKNINDIFDK SEISKIYLNF VDPWPKTHHE KFRLTNSFYL NLFLPLLKQD 150
    GLIEFKTDNL NFFNYSLSVA RENSFCLTFA TKNLYSSAHA KDNIQTEYER 200
    KWSNRGYKIN KLVIKNNISQ 220
    Length:220
    Mass (Da):25,889
    Last modified:March 1, 2003 - v1
    Checksum:iFFA0D7E5F19DA310
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000026 Genomic DNA. Translation: BAC44080.1.
    RefSeqiNP_757676.1. NC_004432.1.

    Genome annotation databases

    EnsemblBacteriaiBAC44080; BAC44080; BAC44080.
    GeneIDi1040935.
    KEGGimpe:MYPE2880.
    PATRICi20019699. VBIMycPen56664_0302.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000026 Genomic DNA. Translation: BAC44080.1 .
    RefSeqi NP_757676.1. NC_004432.1.

    3D structure databases

    ProteinModelPortali Q8EWB6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272633.MYPE2880.

    Proteomic databases

    PRIDEi Q8EWB6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC44080 ; BAC44080 ; BAC44080 .
    GeneIDi 1040935.
    KEGGi mpe:MYPE2880.
    PATRICi 20019699. VBIMycPen56664_0302.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000251689.
    KOi K03439.
    OMAi DNVMTEY.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci MPEN272633:GJBP-300-MONOMER.

    Family and domain databases

    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans."
      Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K., Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.
      Nucleic Acids Res. 30:5293-5300(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HF-2.

    Entry informationi

    Entry nameiTRMB_MYCPE
    AccessioniPrimary (citable) accession number: Q8EWB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3