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Q8EVV1 (SYW_MYCPE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:MYPE4580
OrganismMycoplasma penetrans (strain HF-2) [Complete proteome] [HAMAP]
Taxonomic identifier272633 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136647

Regions

Motif10 – 189"HIGH" region HAMAP-Rule MF_00140
Motif198 – 2025"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site2011ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8EVV1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 6A90BC2CE36DF3B3

FASTA33538,060
        10         20         30         40         50         60 
MKTIVSGIQS TNSLTLGNYL GALKNFINLQ NDNKMFIFIA DMHSITVDFN PKELESNRKS 

        70         80         90        100        110        120 
VASIYAACGL DFDKNIIFYQ SSVLAHTQLS YIITCHSYMG ELSRMTQFKD KSQKTNANGT 

       130        140        150        160        170        180 
TNIPTGLFIY PCLMAADILL YDADLVPVGK DQKQHMELAR DIAIRMNKKY KTNLFKIPEI 

       190        200        210        220        230        240 
YQSEMGAKIM DLVDPSIKMS KSNANTKGTI FLLDKVEDVR KKIMQAKTDS LNKVKYDVEN 

       250        260        270        280        290        300 
QPGVSNLMTI YSCLTNKKTD EIEKEFENKN YGEFKTKVAD AVCLLLEDIQ KKYQIYFNSN 

       310        320        330 
EIEQKLEKNA KKCNEIVNKK INLVQQTLGL GTYKG 

« Hide

References

[1]"The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans."
Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K., Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.
Nucleic Acids Res. 30:5293-5300(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HF-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000026 Genomic DNA. Translation: BAC44248.1.
RefSeqNP_757844.1. NC_004432.1.

3D structure databases

ProteinModelPortalQ8EVV1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272633.MYPE4580.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC44248; BAC44248; BAC44248.
GeneID1041240.
KEGGmpe:MYPE4580.
PATRIC20020067. VBIMycPen56664_0471.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059940.
KOK01867.
OMAFAFYLAC.
OrthoDBEOG686NJQ.
ProtClustDBPRK00927.

Enzyme and pathway databases

BioCycMPEN272633:GJBP-483-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYW_MYCPE
AccessionPrimary (citable) accession number: Q8EVV1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries