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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Mycoplasma penetrans (strain HF-2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137L-tryptophanUniRule annotation1
Binding sitei189ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 11ATPUniRule annotation3
Nucleotide bindingi17 – 18ATPUniRule annotation2
Nucleotide bindingi149 – 151ATPUniRule annotation3
Nucleotide bindingi198 – 202ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPEN272633:G1G3E-483-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:MYPE4580
OrganismiMycoplasma penetrans (strain HF-2)
Taxonomic identifieri272633 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000002522 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366471 – 335Tryptophan--tRNA ligaseAdd BLAST335

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272633.MYPE4580

Structurei

3D structure databases

ProteinModelPortaliQ8EVV1
SMRiQ8EVV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 18"HIGH" regionUniRule annotation9
Motifi198 – 202"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059940
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8EVV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTIVSGIQS TNSLTLGNYL GALKNFINLQ NDNKMFIFIA DMHSITVDFN
60 70 80 90 100
PKELESNRKS VASIYAACGL DFDKNIIFYQ SSVLAHTQLS YIITCHSYMG
110 120 130 140 150
ELSRMTQFKD KSQKTNANGT TNIPTGLFIY PCLMAADILL YDADLVPVGK
160 170 180 190 200
DQKQHMELAR DIAIRMNKKY KTNLFKIPEI YQSEMGAKIM DLVDPSIKMS
210 220 230 240 250
KSNANTKGTI FLLDKVEDVR KKIMQAKTDS LNKVKYDVEN QPGVSNLMTI
260 270 280 290 300
YSCLTNKKTD EIEKEFENKN YGEFKTKVAD AVCLLLEDIQ KKYQIYFNSN
310 320 330
EIEQKLEKNA KKCNEIVNKK INLVQQTLGL GTYKG
Length:335
Mass (Da):38,060
Last modified:March 1, 2003 - v1
Checksum:i6A90BC2CE36DF3B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000026 Genomic DNA Translation: BAC44248.1
RefSeqiWP_011077282.1, NC_004432.1

Genome annotation databases

EnsemblBacteriaiBAC44248; BAC44248; BAC44248
KEGGimpe:MYPE4580

Similar proteinsi

Entry informationi

Entry nameiSYW_MYCPE
AccessioniPrimary (citable) accession number: Q8EVV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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