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Q8EVV1

- SYW_MYCPE

UniProt

Q8EVV1 - SYW_MYCPE

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Mycoplasma penetrans (strain HF-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei201 – 2011ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMPEN272633:GJBP-483-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Short name:
    TrpRSUniRule annotation
    Gene namesi
    Name:trpSUniRule annotation
    Ordered Locus Names:MYPE4580
    OrganismiMycoplasma penetrans (strain HF-2)
    Taxonomic identifieri272633 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000002522: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Tryptophan--tRNA ligasePRO_0000136647Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272633.MYPE4580.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8EVV1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi10 – 189"HIGH" region
    Motifi198 – 2025"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    HOGENOMiHOG000059940.
    KOiK01867.
    OMAiLLNCYTY.
    OrthoDBiEOG686NJQ.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_B. Trp_tRNA_synth_B.
    InterProiIPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8EVV1-1 [UniParc]FASTAAdd to Basket

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    MKTIVSGIQS TNSLTLGNYL GALKNFINLQ NDNKMFIFIA DMHSITVDFN    50
    PKELESNRKS VASIYAACGL DFDKNIIFYQ SSVLAHTQLS YIITCHSYMG 100
    ELSRMTQFKD KSQKTNANGT TNIPTGLFIY PCLMAADILL YDADLVPVGK 150
    DQKQHMELAR DIAIRMNKKY KTNLFKIPEI YQSEMGAKIM DLVDPSIKMS 200
    KSNANTKGTI FLLDKVEDVR KKIMQAKTDS LNKVKYDVEN QPGVSNLMTI 250
    YSCLTNKKTD EIEKEFENKN YGEFKTKVAD AVCLLLEDIQ KKYQIYFNSN 300
    EIEQKLEKNA KKCNEIVNKK INLVQQTLGL GTYKG 335
    Length:335
    Mass (Da):38,060
    Last modified:March 1, 2003 - v1
    Checksum:i6A90BC2CE36DF3B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000026 Genomic DNA. Translation: BAC44248.1.
    RefSeqiNP_757844.1. NC_004432.1.

    Genome annotation databases

    EnsemblBacteriaiBAC44248; BAC44248; BAC44248.
    GeneIDi1041240.
    KEGGimpe:MYPE4580.
    PATRICi20020067. VBIMycPen56664_0471.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000026 Genomic DNA. Translation: BAC44248.1 .
    RefSeqi NP_757844.1. NC_004432.1.

    3D structure databases

    ProteinModelPortali Q8EVV1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272633.MYPE4580.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC44248 ; BAC44248 ; BAC44248 .
    GeneIDi 1041240.
    KEGGi mpe:MYPE4580.
    PATRICi 20020067. VBIMycPen56664_0471.

    Phylogenomic databases

    eggNOGi COG0180.
    HOGENOMi HOG000059940.
    KOi K01867.
    OMAi LLNCYTY.
    OrthoDBi EOG686NJQ.

    Enzyme and pathway databases

    BioCyci MPEN272633:GJBP-483-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_B. Trp_tRNA_synth_B.
    InterProi IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans."
      Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K., Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.
      Nucleic Acids Res. 30:5293-5300(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HF-2.

    Entry informationi

    Entry nameiSYW_MYCPE
    AccessioniPrimary (citable) accession number: Q8EVV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3