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Q8EVR5

- Q8EVR5_MYCPE

UniProt

Q8EVR5 - Q8EVR5_MYCPE

Protein

Cytosine-specific methyltransferase

Gene

MYPE4940

Organism
Mycoplasma penetrans (strain HF-2)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei132 – 1321S-adenosyl-L-homocysteineImported
    Binding sitei375 – 3751S-adenosyl-L-homocysteineImported

    GO - Molecular functioni

    1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
    2. DNA binding Source: InterPro

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    Restriction systemUniRule annotation

    Enzyme and pathway databases

    BioCyciMPEN272633:GJBP-520-MONOMER.

    Protein family/group databases

    REBASEi6754. M.MpeI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytosine-specific methyltransferaseUniRule annotation (EC:2.1.1.37UniRule annotation)
    Gene namesi
    Ordered Locus Names:MYPE4940Imported
    OrganismiMycoplasma penetrans (strain HF-2)Imported
    Taxonomic identifieri272633 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000002522: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi272633.MYPE4940.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DKJX-ray2.15A1-395[»]
    ProteinModelPortaliQ8EVR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 234S-adenosyl-L-homocysteine bindingImported
    Regioni45 – 462S-adenosyl-L-homocysteine bindingImported
    Regioni112 – 1143S-adenosyl-L-homocysteine bindingImported

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000225505.
    KOiK00558.
    OMAiDIHAREM.
    OrthoDBiEOG680WZD.

    Family and domain databases

    Gene3Di3.40.50.150. 2 hits.
    InterProiIPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10629. PTHR10629. 1 hit.
    PfamiPF00145. DNA_methylase. 1 hit.
    [Graphical view]
    PRINTSiPR00105. C5METTRFRASE.
    SUPFAMiSSF53335. SSF53335. 2 hits.
    TIGRFAMsiTIGR00675. dcm. 1 hit.
    PROSITEiPS00094. C5_MTASE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8EVR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSNKDKIKV IKVFEAFAGI GSQFKALKNI ARSKNWEIQH SGMVEWFVDA    50
    IVSYVAIHSK NFNPKIEQLD KDILSISNDS KMPISEYGIK KINNTIKASY 100
    LNYAKKHFNN LFDIKKVNKD NFPKNIDIFT YSFPCQDLSV QGLQKGIDKE 150
    LNTRSGLLWE IERILEEIKN SFSKEEMPKY LLMENVKNLL SHKNKKNYNT 200
    WLKQLEKFGY KSKTYLLNSK NFDNCQNRER VFCLSIRDDY LEKTGFKFKE 250
    LEKVKNPPKK IKDILVDSSN YKYLNLNKYE TTTFRETKSN IISRSLKNYT 300
    TFNSENYVYN INGIGPTLTA SGANSRIKIE TQQGVRYLTP LECFKYMQFD 350
    VNDFKKVQST NLISENKMIY IAGNSIPVKI LEAIFNTLEF VNNEE 395
    Length:395
    Mass (Da):46,106
    Last modified:March 1, 2003 - v1
    Checksum:iCB06EB0EF415132E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000026 Genomic DNA. Translation: BAC44284.1.
    RefSeqiNP_757880.1. NC_004432.1.
    WP_011077318.1. NC_004432.1.

    Genome annotation databases

    EnsemblBacteriaiBAC44284; BAC44284; BAC44284.
    GeneIDi1041330.
    KEGGimpe:MYPE4940.
    PATRICi20020137. VBIMycPen56664_0505.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000026 Genomic DNA. Translation: BAC44284.1 .
    RefSeqi NP_757880.1. NC_004432.1.
    WP_011077318.1. NC_004432.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DKJ X-ray 2.15 A 1-395 [» ]
    ProteinModelPortali Q8EVR5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272633.MYPE4940.

    Protein family/group databases

    REBASEi 6754. M.MpeI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC44284 ; BAC44284 ; BAC44284 .
    GeneIDi 1041330.
    KEGGi mpe:MYPE4940.
    PATRICi 20020137. VBIMycPen56664_0505.

    Phylogenomic databases

    HOGENOMi HOG000225505.
    KOi K00558.
    OMAi DIHAREM.
    OrthoDBi EOG680WZD.

    Enzyme and pathway databases

    BioCyci MPEN272633:GJBP-520-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 2 hits.
    InterProi IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10629. PTHR10629. 1 hit.
    Pfami PF00145. DNA_methylase. 1 hit.
    [Graphical view ]
    PRINTSi PR00105. C5METTRFRASE.
    SUPFAMi SSF53335. SSF53335. 2 hits.
    TIGRFAMsi TIGR00675. dcm. 1 hit.
    PROSITEi PS00094. C5_MTASE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans."
      Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K., Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.
      Nucleic Acids Res. 30:5293-5300(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HF-2Imported.
    2. "CpG underrepresentation and the bacterial CpG-specific DNA methyltransferase M.MpeI."
      Wojciechowski M., Czapinska H., Bochtler M.
      Proc. Natl. Acad. Sci. U.S.A. 110:105-110(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE.

    Entry informationi

    Entry nameiQ8EVR5_MYCPE
    AccessioniPrimary (citable) accession number: Q8EVR5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3