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Q8EVR5 (Q8EVR5_MYCPE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Cytosine-specific methyltransferase RuleBase RU000417

EC=2.1.1.37 RuleBase RU000417
Gene names
Ordered Locus Names:MYPE4940 EMBL BAC44284.1
OrganismMycoplasma penetrans (strain HF-2) [Complete proteome] [HAMAP]
Taxonomic identifier272633 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. RuleBase RU000417

Sequence similarities

Belongs to the C5-methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region20 – 234S-adenosyl-L-homocysteine binding PDB 4DKJ
Region45 – 462S-adenosyl-L-homocysteine binding PDB 4DKJ
Region112 – 1143S-adenosyl-L-homocysteine binding PDB 4DKJ

Sites

Binding site1321S-adenosyl-L-homocysteine PDB 4DKJ
Binding site3751S-adenosyl-L-homocysteine PDB 4DKJ

Sequences

Sequence LengthMass (Da)Tools
Q8EVR5 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: CB06EB0EF415132E

FASTA39546,106
        10         20         30         40         50         60 
MNSNKDKIKV IKVFEAFAGI GSQFKALKNI ARSKNWEIQH SGMVEWFVDA IVSYVAIHSK 

        70         80         90        100        110        120 
NFNPKIEQLD KDILSISNDS KMPISEYGIK KINNTIKASY LNYAKKHFNN LFDIKKVNKD 

       130        140        150        160        170        180 
NFPKNIDIFT YSFPCQDLSV QGLQKGIDKE LNTRSGLLWE IERILEEIKN SFSKEEMPKY 

       190        200        210        220        230        240 
LLMENVKNLL SHKNKKNYNT WLKQLEKFGY KSKTYLLNSK NFDNCQNRER VFCLSIRDDY 

       250        260        270        280        290        300 
LEKTGFKFKE LEKVKNPPKK IKDILVDSSN YKYLNLNKYE TTTFRETKSN IISRSLKNYT 

       310        320        330        340        350        360 
TFNSENYVYN INGIGPTLTA SGANSRIKIE TQQGVRYLTP LECFKYMQFD VNDFKKVQST 

       370        380        390 
NLISENKMIY IAGNSIPVKI LEAIFNTLEF VNNEE 

« Hide

References

« Hide 'large scale' references
[1]"The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans."
Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K., Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.
Nucleic Acids Res. 30:5293-5300(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HF-2.
[2]"CpG underrepresentation and the bacterial CpG-specific DNA methyltransferase M.MpeI."
Wojciechowski M., Czapinska H., Bochtler M.
Proc. Natl. Acad. Sci. U.S.A. 110:105-110(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000026 Genomic DNA. Translation: BAC44284.1.
RefSeqNP_757880.1. NC_004432.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4DKJX-ray2.15A1-395[»]
ProteinModelPortalQ8EVR5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272633.MYPE4940.

Protein family/group databases

REBASE6754. M.MpeI.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC44284; BAC44284; BAC44284.
GeneID1041330.
KEGGmpe:MYPE4940.
PATRIC20020137. VBIMycPen56664_0505.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000225505.
KOK00558.
OMADIHAREM.
OrthoDBEOG680WZD.

Enzyme and pathway databases

BioCycMPEN272633:GJBP-520-MONOMER.

Family and domain databases

Gene3D3.40.50.150. 2 hits.
InterProIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERPTHR10629. PTHR10629. 1 hit.
PfamPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSPR00105. C5METTRFRASE.
SUPFAMSSF53335. SSF53335. 2 hits.
TIGRFAMsTIGR00675. dcm. 1 hit.
PROSITEPS00094. C5_MTASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ8EVR5_MYCPE
AccessionPrimary (citable) accession number: Q8EVR5
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)