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Q8EVR5

- Q8EVR5_MYCPE

UniProt

Q8EVR5 - Q8EVR5_MYCPE

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Protein
Cytosine-specific methyltransferase
Gene
MYPE4940
Organism
Mycoplasma penetrans (strain HF-2)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei132 – 1321S-adenosyl-L-homocysteineImported
Binding sitei375 – 3751S-adenosyl-L-homocysteineImported

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: InterPro

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

Restriction systemUniRule annotation

Enzyme and pathway databases

BioCyciMPEN272633:GJBP-520-MONOMER.

Protein family/group databases

REBASEi6754. M.MpeI.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosine-specific methyltransferaseUniRule annotation (EC:2.1.1.37UniRule annotation)
Gene namesi
Ordered Locus Names:MYPE4940Imported
OrganismiMycoplasma penetrans (strain HF-2)
Taxonomic identifieri272633 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000002522: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi272633.MYPE4940.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DKJX-ray2.15A1-395[»]
ProteinModelPortaliQ8EVR5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 234S-adenosyl-L-homocysteine bindingImported
Regioni45 – 462S-adenosyl-L-homocysteine bindingImported
Regioni112 – 1143S-adenosyl-L-homocysteine bindingImported

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000225505.
KOiK00558.
OMAiDIHAREM.
OrthoDBiEOG680WZD.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS00094. C5_MTASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8EVR5-1 [UniParc]FASTAAdd to Basket

« Hide

MNSNKDKIKV IKVFEAFAGI GSQFKALKNI ARSKNWEIQH SGMVEWFVDA    50
IVSYVAIHSK NFNPKIEQLD KDILSISNDS KMPISEYGIK KINNTIKASY 100
LNYAKKHFNN LFDIKKVNKD NFPKNIDIFT YSFPCQDLSV QGLQKGIDKE 150
LNTRSGLLWE IERILEEIKN SFSKEEMPKY LLMENVKNLL SHKNKKNYNT 200
WLKQLEKFGY KSKTYLLNSK NFDNCQNRER VFCLSIRDDY LEKTGFKFKE 250
LEKVKNPPKK IKDILVDSSN YKYLNLNKYE TTTFRETKSN IISRSLKNYT 300
TFNSENYVYN INGIGPTLTA SGANSRIKIE TQQGVRYLTP LECFKYMQFD 350
VNDFKKVQST NLISENKMIY IAGNSIPVKI LEAIFNTLEF VNNEE 395
Length:395
Mass (Da):46,106
Last modified:March 1, 2003 - v1
Checksum:iCB06EB0EF415132E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000026 Genomic DNA. Translation: BAC44284.1.
RefSeqiNP_757880.1. NC_004432.1.
WP_011077318.1. NC_004432.1.

Genome annotation databases

EnsemblBacteriaiBAC44284; BAC44284; BAC44284.
GeneIDi1041330.
KEGGimpe:MYPE4940.
PATRICi20020137. VBIMycPen56664_0505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000026 Genomic DNA. Translation: BAC44284.1 .
RefSeqi NP_757880.1. NC_004432.1.
WP_011077318.1. NC_004432.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DKJ X-ray 2.15 A 1-395 [» ]
ProteinModelPortali Q8EVR5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272633.MYPE4940.

Protein family/group databases

REBASEi 6754. M.MpeI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC44284 ; BAC44284 ; BAC44284 .
GeneIDi 1041330.
KEGGi mpe:MYPE4940.
PATRICi 20020137. VBIMycPen56664_0505.

Phylogenomic databases

HOGENOMi HOG000225505.
KOi K00558.
OMAi DIHAREM.
OrthoDBi EOG680WZD.

Enzyme and pathway databases

BioCyci MPEN272633:GJBP-520-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 2 hits.
InterProi IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 1 hit.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
SUPFAMi SSF53335. SSF53335. 2 hits.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS00094. C5_MTASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans."
    Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K., Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.
    Nucleic Acids Res. 30:5293-5300(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HF-2.
  2. "CpG underrepresentation and the bacterial CpG-specific DNA methyltransferase M.MpeI."
    Wojciechowski M., Czapinska H., Bochtler M.
    Proc. Natl. Acad. Sci. U.S.A. 110:105-110(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE.

Entry informationi

Entry nameiQ8EVR5_MYCPE
AccessioniPrimary (citable) accession number: Q8EVR5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3