Cytosine-specific methyltransferase - Mycoplasma penetrans (strain HF-2)

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Q8EVR5 (Q8EVR5_MYCPE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 69. History...

Clusters with 100%, 90%, 50% identity |

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
Cytosine-specific methyltransferase RuleBase RU000417
EC=2.1.1.37 RuleBase RU000417

Gene names

Ordered Locus Names:

MYPE4940

Organism

Mycoplasma penetrans (strain HF-2) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma ›

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. RuleBase RU000417
Sequence similarities	Belongs to the C5-methyltransferase family. RuleBase RU000416

Ontologies

Keywords
Biological process	Restriction system RuleBase RU004244
Molecular function	Methyltransferase RuleBase RU000417 EMBL BAC44284.1 Transferase
Technical term	3D-structure PDB 4DKJ Complete proteome
Gene Ontology (GO)
Biological_process	C-5 methylation of cytosine Inferred from electronic annotation. Source: GOC DNA restriction-modification system Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA (cytosine-5-)-methyltransferase activity Inferred from electronic annotation. Source: EC DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q8EVR5 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: CB06EB0EF415132E
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395

46,106

        10         20         30         40         50         60 
MNSNKDKIKV IKVFEAFAGI GSQFKALKNI ARSKNWEIQH SGMVEWFVDA IVSYVAIHSK 

        70         80         90        100        110        120 
NFNPKIEQLD KDILSISNDS KMPISEYGIK KINNTIKASY LNYAKKHFNN LFDIKKVNKD 

       130        140        150        160        170        180 
NFPKNIDIFT YSFPCQDLSV QGLQKGIDKE LNTRSGLLWE IERILEEIKN SFSKEEMPKY 

       190        200        210        220        230        240 
LLMENVKNLL SHKNKKNYNT WLKQLEKFGY KSKTYLLNSK NFDNCQNRER VFCLSIRDDY 

       250        260        270        280        290        300 
LEKTGFKFKE LEKVKNPPKK IKDILVDSSN YKYLNLNKYE TTTFRETKSN IISRSLKNYT 

       310        320        330        340        350        360 
TFNSENYVYN INGIGPTLTA SGANSRIKIE TQQGVRYLTP LECFKYMQFD VNDFKKVQST 

       370        380        390 
NLISENKMIY IAGNSIPVKI LEAIFNTLEF VNNEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans." Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K., Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M. Nucleic Acids Res. 30:5293-5300(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HF-2.
[2]	"CpG underrepresentation and the bacterial CpG-specific DNA methyltransferase M.MpeI." Wojciechowski M., Czapinska H., Bochtler M. Proc. Natl. Acad. Sci. U.S.A. 110:105-110(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BA000026 Genomic DNA. Translation: BAC44284.1.

RefSeq

NP_757880.1. NC_004432.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4DKJ	X-ray	2.15	A	1-395	[»]

ProteinModelPortal

ModBase

Protein-protein interaction databases

STRING

272633.MYPE4940.

Protein family/group databases

REBASE

6754. M.MpeI.

Protocols and materials databases

StructuralBiologyKnowledgebase

Genome annotation databases

EnsemblBacteria

BAC44284; BAC44284; BAC44284.

GeneID

KEGG

PATRIC

20020137. VBIMycPen56664_0505.

Organism-specific databases

CMR

Phylogenomic databases

HOGENOM

KO

OMA

ProtClustDB

Enzyme and pathway databases

BioCyc

MPEN272633:GJBP-520-MONOMER.

Family and domain databases

InterPro

IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
[Graphical view]

PANTHER

PTHR10629. PTHR10629. 1 hit.

Pfam

PF00145. DNA_methylase. 1 hit.
[Graphical view]

PRINTS

PR00105. C5METTRFRASE.

TIGRFAMs

TIGR00675. dcm. 1 hit.

PROSITE

PS00094. C5_MTASE_1. 1 hit.
[Graphical view]

ProtoNet

Entry information

Entry name

Q8EVR5_MYCPE

Accession

Primary (citable) accession number: Q8EVR5

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info