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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Mycoplasma penetrans (strain HF-2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciMPEN272633:G1G3E-585-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:MYPE5610
OrganismiMycoplasma penetrans (strain HF-2)
Taxonomic identifieri272633 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000002522 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000873551 – 160Peptide methionine sulfoxide reductase MsrAAdd BLAST160

Interactioni

Protein-protein interaction databases

STRINGi272633.MYPE5610

Structurei

3D structure databases

ProteinModelPortaliQ8EVK2
SMRiQ8EVK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108HW8 Bacteria
COG0225 LUCA
HOGENOMiHOG000263863
KOiK07304
OMAiGYCAFVV
OrthoDBiPOG091H059H

Family and domain databases

Gene3Di3.30.1060.10, 1 hit
HAMAPiMF_01401 MsrA, 1 hit
InterProiView protein in InterPro
IPR002569 Met_Sox_Rdtase_MsrA
IPR036509 Met_Sox_Rdtase_MsrA_sf
PfamiView protein in Pfam
PF01625 PMSR, 1 hit
SUPFAMiSSF55068 SSF55068, 1 hit
TIGRFAMsiTIGR00401 msrA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8EVK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKKIYLAGG CFWGIEQYYN LNQKIISTNV GYLNSKIDNP TYKDVCNNIT
60 70 80 90 100
DAVEAVELTY DDQVISLNEI IDLLFKVIDP TSINKQGNDI GRQYRTGIYS
110 120 130 140 150
RDSNELMAIQ EKINELQNNY SKLIQTEVML VDNYYLAEEY HQKYLEKNPN
160
GYCHINLKAK
Length:160
Mass (Da):18,579
Last modified:March 1, 2003 - v1
Checksum:i905D3BC6CC5C90D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000026 Genomic DNA Translation: BAC44351.1
RefSeqiWP_011077384.1, NC_004432.1

Genome annotation databases

EnsemblBacteriaiBAC44351; BAC44351; BAC44351
KEGGimpe:MYPE5610

Similar proteinsi

Entry informationi

Entry nameiMSRA_MYCPE
AccessioniPrimary (citable) accession number: Q8EVK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health