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Q8EVH2

- PFKA_MYCPE

UniProt

Q8EVH2 - PFKA_MYCPE

Protein

Probable ATP-dependent 6-phosphofructokinase

Gene

pfkA

Organism
Mycoplasma penetrans (strain HF-2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.By similarity

    Catalytic activityi

    ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111ATP; via amide nitrogenBy similarity
    Metal bindingi103 – 1031Magnesium; catalyticBy similarity
    Active sitei127 – 1271Proton acceptorBy similarity
    Binding sitei222 – 2221SubstrateBy similarity
    Binding sitei249 – 2491Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi72 – 732ATPBy similarity
    Nucleotide bindingi102 – 1054ATPBy similarity

    GO - Molecular functioni

    1. 6-phosphofructokinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. fructose 6-phosphate metabolic process Source: InterPro
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMPEN272633:GJBP-618-MONOMER.
    UniPathwayiUPA00109; UER00182.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ATP-dependent 6-phosphofructokinase (EC:2.7.1.11)
    Short name:
    ATP-PFK
    Short name:
    Phosphofructokinase
    Alternative name(s):
    Phosphohexokinase
    Gene namesi
    Name:pfkA
    Ordered Locus Names:MYPE5920
    OrganismiMycoplasma penetrans (strain HF-2)
    Taxonomic identifieri272633 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000002522: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. 6-phosphofructokinase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322Probable ATP-dependent 6-phosphofructokinasePRO_0000111964Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer or homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi272633.MYPE5920.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8EVH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni125 – 1273Substrate bindingBy similarity
    Regioni169 – 1713Substrate bindingBy similarity
    Regioni255 – 2584Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0205.
    HOGENOMiHOG000248870.
    KOiK00850.
    OMAiGFGGRCV.
    OrthoDBiEOG644ZRM.

    Family and domain databases

    InterProiIPR012003. ATP_PFK_prok.
    IPR022953. Phosphofructokinase.
    IPR000023. Phosphofructokinase_dom.
    [Graphical view]
    PfamiPF00365. PFK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
    PRINTSiPR00476. PHFRCTKINASE.
    SUPFAMiSSF53784. SSF53784. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8EVH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIAILTSG GDASTMNKCL STFITYASKY NCEVVFVKNG YKGIYDNEFV    50
    KPDYTETKSW WSLPGTKIYS SRFPEILDEQ VRKQMVDNLH KNSIDTLVVI 100
    GGDGSYKGAR LLSKSGIKVI GLPGTIDNDI ASTSYSIGFD TSLNAIVNSI 150
    KEIKSCMDSH ANVAMIEIMG RHCIDLTVFA GIATEADIII TPESFYTPQQ 200
    LLAKINEKRK TNSRGIIILY VELLLGTENI PTVEEYIKYI QANSKESVKK 250
    NILGYLQRGG NPTAMDMIRA SLMTEHALKM ISENQYNKII GVDEFKVVSY 300
    DLETAINMKN PSRKDLIDKF FN 322
    Length:322
    Mass (Da):35,983
    Last modified:March 1, 2003 - v1
    Checksum:iE88ED024B048CCD3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000026 Genomic DNA. Translation: BAC44382.1.
    RefSeqiNP_757978.1. NC_004432.1.
    WP_011077414.1. NC_004432.1.

    Genome annotation databases

    EnsemblBacteriaiBAC44382; BAC44382; BAC44382.
    GeneIDi1041468.
    KEGGimpe:MYPE5920.
    PATRICi20020336. VBIMycPen56664_0604.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000026 Genomic DNA. Translation: BAC44382.1 .
    RefSeqi NP_757978.1. NC_004432.1.
    WP_011077414.1. NC_004432.1.

    3D structure databases

    ProteinModelPortali Q8EVH2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272633.MYPE5920.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC44382 ; BAC44382 ; BAC44382 .
    GeneIDi 1041468.
    KEGGi mpe:MYPE5920.
    PATRICi 20020336. VBIMycPen56664_0604.

    Phylogenomic databases

    eggNOGi COG0205.
    HOGENOMi HOG000248870.
    KOi K00850.
    OMAi GFGGRCV.
    OrthoDBi EOG644ZRM.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00182 .
    BioCyci MPEN272633:GJBP-618-MONOMER.

    Family and domain databases

    InterProi IPR012003. ATP_PFK_prok.
    IPR022953. Phosphofructokinase.
    IPR000023. Phosphofructokinase_dom.
    [Graphical view ]
    Pfami PF00365. PFK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
    PRINTSi PR00476. PHFRCTKINASE.
    SUPFAMi SSF53784. SSF53784. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans."
      Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K., Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.
      Nucleic Acids Res. 30:5293-5300(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HF-2.

    Entry informationi

    Entry nameiPFKA_MYCPE
    AccessioniPrimary (citable) accession number: Q8EVH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3