Reviewed, UniProtKB/Swiss-Prot Q8EVF5 (OTCC_MYCPE)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase, catabolic
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	MYPE6090

Organism

Mycoplasma penetrans [Complete proteome] [HAMAP]

Taxonomic identifier

28227 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000112953
Regions
	Region	59 – 63	5	Carbamoyl phosphate binding By similarity
	Region	275 – 278	4	Ornithine binding By similarity
Sites
	Binding site	110	1	Carbamoyl phosphate By similarity
	Binding site	137	1	Carbamoyl phosphate By similarity
	Site	32	1	Important for structural integrity By similarity
	Site	150	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8EVF5-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: D21012AF209307A7	FASTA	342	38,036
	10 20 30 40 50 60 MPVNLKGRSL DSLLNFTTEE VQHLIDLSID LKKAKYQGLH INNRPLVGKN IAILFQKDST 70 80 90 100 110 120 RTRCAFEVAA SDLGAGVTYI GPSGSNMGKK ESIEDTAKVL GRFYDGIEFR GFAQSDVDAL 130 140 150 160 170 180 VKYSGVPVWN GLTDDEHPTQ IIADFMTMKE KFGNLKNKKI VFIGDYKNNV GVSTMIGAAF 190 200 210 220 230 240 NGMHVVMCGP DNYKNEIDKN VLAKCIELFK RNGGSLRFST DKILAAQDAD VIYTDVWVSL 250 260 270 280 290 300 GEPFELFDKR IGELKNFQVD MNMIKAAKND VIFLHCLPAF HDDHTSFSKE VATTLGAKYP 310 320 330 340 IVAKGEMEVT DEVFQSLHNK AFDQAENRMH SIKAIILSTI GY

References

[1]

"The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans." Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K., Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M. Nucleic Acids Res. 30:5293-5300(2002) [PubMed: 12466555] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HF-2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000026 Genomic DNA. Translation: BAC44399.1.
RefSeq	NP_757995.1.
3D structure databases
HSSP	HSSP built from PDB template 1AKM based on UniProtKB P04391.
ModBase	Search...
Genome annotation databases
GeneID	1041489.
GenomeReviews	Gene locus MYPE6090 in contig BA000026_GR.
KEGG	mpe:MYPE6090.
NMPDR	fig|272633.1.peg.609.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8EVF5.
OMA	FMTIKEH.
Enzyme and pathway databases
BioCyc	MPEN272633:MYPE6090-MON.
BRENDA	2.1.3.3. 292832.
Family and domain databases
HAMAP	MF_01109. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_MYCPE

Accession

Primary (citable) accession number: Q8EVF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	March 1, 2003
Last modified:	November 3, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)