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Q8EVF2 (SYR_MYCPE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:MYPE6120
OrganismMycoplasma penetrans (strain HF-2) [Complete proteome] [HAMAP]
Taxonomic identifier272633 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 564564Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242052

Regions

Motif130 – 14011"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q8EVF2 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 879573694136E010

FASTA56465,016
        10         20         30         40         50         60 
MIKTTIIASI KDLIKDAVKD KFKITIDLND FVVDKAKSIE FGDFYSNVAM ILASKLKKNP 

        70         80         90        100        110        120 
ILIAEEICEY LKNHKTNLFE STEAVKPGYI NVFLSNSVKS DLFKQINKDK DTYGIFEPKK 

       130        140        150        160        170        180 
VAYNIEFVSA NPTGSLHIGH ARNAALGQTL GNVWKAYGYT IEQEYYINDG GNQINNLGMS 

       190        200        210        220        230        240 
VFYRYLQKCG KDVQMEEDFY QGSEPIAVAE LIYKEHKDKF VNVKYSATKI EDEKVFDFFR 

       250        260        270        280        290        300 
DFSKTELMNI IKKDLKDFSV HFDRYFPESK IYEMKLVDPT IKKLGKYVYE KDGALWLKTT 

       310        320        330        340        350        360 
EFGDDKDRVI VKSDKSFTYF MPDIAYHDIK ATRTINGLKT DKIFNIWGAD HASYVDRMTV 

       370        380        390        400        410        420 
ALQCLGFKKD IMHVIVMQMV KLTKNGKEFK MSKRSGNSLT LRDLINAIGV DNSRWELISQ 

       430        440        450        460        470        480 
AAESHIEIDV EKFTSADSTS NLSYVLYAYS RIQKILEKNE SLLKESKSYN TDLLTNLKEK 

       490        500        510        520        530        540 
DMIAMLFYYP QTIANIAKSY EVHKIPIFLY TLANLLHSYY SEVKIIDESN KELLIQRLHL 

       550        560 
LQCVNQVIKN GLKLLDIEAK VLNK 

« Hide

References

[1]"The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans."
Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K., Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.
Nucleic Acids Res. 30:5293-5300(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HF-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000026 Genomic DNA. Translation: BAC44402.1.
RefSeqNP_757998.1. NC_004432.1.

3D structure databases

ProteinModelPortalQ8EVF2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272633.MYPE6120.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC44402; BAC44402; BAC44402.
GeneID1041494.
KEGGmpe:MYPE6120.
PATRIC20020380. VBIMycPen56664_0626.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMARFIMLTR.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycMPEN272633:GJBP-638-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_MYCPE
AccessionPrimary (citable) accession number: Q8EVF2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries