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Q8EUV2 (PGK_MYCPE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:MYPE8160
OrganismMycoplasma penetrans (strain HF-2) [Complete proteome] [HAMAP]
Taxonomic identifier272633 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145970

Regions

Nucleotide binding368 – 3714ATP By similarity
Region24 – 263Substrate binding By similarity
Region64 – 674Substrate binding By similarity

Sites

Binding site411Substrate By similarity
Binding site1271Substrate By similarity
Binding site1691Substrate By similarity
Binding site2201ATP By similarity
Binding site3071ATP; via carbonyl oxygen By similarity
Binding site3381ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8EUV2 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 10E631A553C41B7E

FASTA47150,727
        10         20         30         40         50         60 
MEYNKKIVTD LTDLKGKKVI LRCDFNVPIN KTSGEITDYT RIDAALQTIN YLLDKGVKLI 

        70         80         90        100        110        120 
VLSHLSRVKT LEDISSGKKS LKVVHKALKN RLLGKTVLFE ENNRNKDLPK IIDGMEEGSL 

       130        140        150        160        170        180 
LLLENTRYAD VNEKGEVVKL ESKNDPSLGK FWASLADIFV NDAFGTSHRA HASNVGIAKN 

       190        200        210        220        230        240 
IKESAIGFLV NKELAKLSKA VVNPRKPVVA IFGGAKVSDK VPSIKNIGKF ADKILIGGGM 

       250        260        270        280        290        300 
AFIFLKAKGF EIGKSLYEDD QLELTKELLS EFGNKIVLPV DAVVADSIKA AKGKRYDMEQ 

       310        320        330        340        350        360 
FPADLAGFDV GKKTIKLFKK ELKLAETVIW NGPLGVFEND AFNKGTLKVC KYIAKITAKK 

       370        380        390        400        410        420 
GCYSVIGGGD SAAAAAKCGV THSFSHISTG GGASLEFFSG VELPGVACIK NKGEEGKVEA 

       430        440        450        460        470 
VKEKTTTTTE SASKEKSSTA KTASKPATSK TTAAKKPAEK KPAAKKPAAK K 

« Hide

References

[1]"The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans."
Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K., Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.
Nucleic Acids Res. 30:5293-5300(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HF-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000026 Genomic DNA. Translation: BAC44609.1.
RefSeqNP_758205.1. NC_004432.1.

3D structure databases

ProteinModelPortalQ8EUV2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272633.MYPE8160.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC44609; BAC44609; BAC44609.
GeneID1041556.
KEGGmpe:MYPE8160.
PATRIC20020812. VBIMycPen56664_0840.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMAFPVDYVT.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

BioCycMPEN272633:GJBP-847-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_MYCPE
AccessionPrimary (citable) accession number: Q8EUV2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways