Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8EUQ1 (FTHS_MYCPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:MYPE8690
OrganismMycoplasma penetrans (strain HF-2) [Complete proteome] [HAMAP]
Taxonomic identifier272633 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199362

Regions

Nucleotide binding46 – 538ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8EUQ1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 2F9A209EA3D87C9A

FASTA53059,817
        10         20         30         40         50         60 
MTNNIFKYFN IKELEKFGKF YKVKKEYEIP KKLESKLILV TSINPTPEGE GKTTTLIGIN 

        70         80         90        100        110        120 
DCLNYFGKES IACLRQPSMG PYFGIKGGAT GSGKCEIQNP EKVNCGFTND FYAIEAANNL 

       130        140        150        160        170        180 
IMSVIENEIY FNTDLEIDPQ KIIWKRCIDI NDRSLRDINY QVSKNTKINS SFSITAASNL 

       190        200        210        220        230        240 
MALFCLAKSK SDFKKRIENT LVAFSKSNKA IYVKDLNIID SIMLILDDAL KPNLVFSQDN 

       250        260        270        280        290        300 
NPIIMHGGPF ANIAHGCNSV IALSCGLNKA EYVLTEAGFG SELGAEKFIN ILCRETNLVP 

       310        320        330        340        350        360 
NLVVLTITLK AIKYHGVNNS NNTSPLTDEK EKIDIGFNNV IHHFNLLKNL NLNVCIVINK 

       370        380        390        400        410        420 
FSDDNKNELD YLFNKSSELT KTVISTMWQD GASKNKSLFE TIIESVQEPK PINWTYDLKD 

       430        440        450        460        470        480 
NAVNKINDLS TKVYNGATIT YSDLATAKLK DNENWIQDYY VCGAKTPYSP SIKNEYMDTN 

       490        500        510        520        530 
KHDIHVEDIE INHAVKFIIP IFSKTFLMPG LPKVPNAKKI KINFDKFKYE 

« Hide

References

[1]"The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans."
Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K., Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.
Nucleic Acids Res. 30:5293-5300(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HF-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000026 Genomic DNA. Translation: BAC44661.1.
RefSeqNP_758257.1. NC_004432.1.

3D structure databases

ProteinModelPortalQ8EUQ1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272633.MYPE8690.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC44661; BAC44661; BAC44661.
GeneID1041462.
KEGGmpe:MYPE8690.
PATRIC20020928. VBIMycPen56664_0896.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAQLRYIND.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycMPEN272633:GJBP-900-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_MYCPE
AccessionPrimary (citable) accession number: Q8EUQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways