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Q8EUQ1

- FTHS_MYCPE

UniProt

Q8EUQ1 - FTHS_MYCPE

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Mycoplasma penetrans (strain HF-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 538ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPEN272633:GJBP-900-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:MYPE8690
OrganismiMycoplasma penetrans (strain HF-2)
Taxonomic identifieri272633 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000002522: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Formate--tetrahydrofolate ligasePRO_0000199362Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272633.MYPE8690.

Structurei

3D structure databases

ProteinModelPortaliQ8EUQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiQLRYIND.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8EUQ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNNIFKYFN IKELEKFGKF YKVKKEYEIP KKLESKLILV TSINPTPEGE
60 70 80 90 100
GKTTTLIGIN DCLNYFGKES IACLRQPSMG PYFGIKGGAT GSGKCEIQNP
110 120 130 140 150
EKVNCGFTND FYAIEAANNL IMSVIENEIY FNTDLEIDPQ KIIWKRCIDI
160 170 180 190 200
NDRSLRDINY QVSKNTKINS SFSITAASNL MALFCLAKSK SDFKKRIENT
210 220 230 240 250
LVAFSKSNKA IYVKDLNIID SIMLILDDAL KPNLVFSQDN NPIIMHGGPF
260 270 280 290 300
ANIAHGCNSV IALSCGLNKA EYVLTEAGFG SELGAEKFIN ILCRETNLVP
310 320 330 340 350
NLVVLTITLK AIKYHGVNNS NNTSPLTDEK EKIDIGFNNV IHHFNLLKNL
360 370 380 390 400
NLNVCIVINK FSDDNKNELD YLFNKSSELT KTVISTMWQD GASKNKSLFE
410 420 430 440 450
TIIESVQEPK PINWTYDLKD NAVNKINDLS TKVYNGATIT YSDLATAKLK
460 470 480 490 500
DNENWIQDYY VCGAKTPYSP SIKNEYMDTN KHDIHVEDIE INHAVKFIIP
510 520 530
IFSKTFLMPG LPKVPNAKKI KINFDKFKYE
Length:530
Mass (Da):59,817
Last modified:March 1, 2003 - v1
Checksum:i2F9A209EA3D87C9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000026 Genomic DNA. Translation: BAC44661.1.
RefSeqiNP_758257.1. NC_004432.1.

Genome annotation databases

EnsemblBacteriaiBAC44661; BAC44661; BAC44661.
GeneIDi1041462.
KEGGimpe:MYPE8690.
PATRICi20020928. VBIMycPen56664_0896.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000026 Genomic DNA. Translation: BAC44661.1 .
RefSeqi NP_758257.1. NC_004432.1.

3D structure databases

ProteinModelPortali Q8EUQ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272633.MYPE8690.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC44661 ; BAC44661 ; BAC44661 .
GeneIDi 1041462.
KEGGi mpe:MYPE8690.
PATRICi 20020928. VBIMycPen56664_0896.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi QLRYIND.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci MPEN272633:GJBP-900-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans."
    Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K., Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.
    Nucleic Acids Res. 30:5293-5300(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HF-2.

Entry informationi

Entry nameiFTHS_MYCPE
AccessioniPrimary (citable) accession number: Q8EUQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3