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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Mycoplasma penetrans (strain HF-2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi46 – 53ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPEN272633:G1G3E-897-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:MYPE8690
OrganismiMycoplasma penetrans (strain HF-2)
Taxonomic identifieri272633 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000002522 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001993621 – 530Formate--tetrahydrofolate ligaseAdd BLAST530

Proteomic databases

PRIDEiQ8EUQ1

Interactioni

Protein-protein interaction databases

STRINGi272633.MYPE8690

Structurei

3D structure databases

ProteinModelPortaliQ8EUQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM
OrthoDBiPOG091H01S8

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8EUQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNNIFKYFN IKELEKFGKF YKVKKEYEIP KKLESKLILV TSINPTPEGE
60 70 80 90 100
GKTTTLIGIN DCLNYFGKES IACLRQPSMG PYFGIKGGAT GSGKCEIQNP
110 120 130 140 150
EKVNCGFTND FYAIEAANNL IMSVIENEIY FNTDLEIDPQ KIIWKRCIDI
160 170 180 190 200
NDRSLRDINY QVSKNTKINS SFSITAASNL MALFCLAKSK SDFKKRIENT
210 220 230 240 250
LVAFSKSNKA IYVKDLNIID SIMLILDDAL KPNLVFSQDN NPIIMHGGPF
260 270 280 290 300
ANIAHGCNSV IALSCGLNKA EYVLTEAGFG SELGAEKFIN ILCRETNLVP
310 320 330 340 350
NLVVLTITLK AIKYHGVNNS NNTSPLTDEK EKIDIGFNNV IHHFNLLKNL
360 370 380 390 400
NLNVCIVINK FSDDNKNELD YLFNKSSELT KTVISTMWQD GASKNKSLFE
410 420 430 440 450
TIIESVQEPK PINWTYDLKD NAVNKINDLS TKVYNGATIT YSDLATAKLK
460 470 480 490 500
DNENWIQDYY VCGAKTPYSP SIKNEYMDTN KHDIHVEDIE INHAVKFIIP
510 520 530
IFSKTFLMPG LPKVPNAKKI KINFDKFKYE
Length:530
Mass (Da):59,817
Last modified:March 1, 2003 - v1
Checksum:i2F9A209EA3D87C9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000026 Genomic DNA Translation: BAC44661.1
RefSeqiWP_011077690.1, NC_004432.1

Genome annotation databases

EnsemblBacteriaiBAC44661; BAC44661; BAC44661
KEGGimpe:MYPE8690

Similar proteinsi

Entry informationi

Entry nameiFTHS_MYCPE
AccessioniPrimary (citable) accession number: Q8EUQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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