ID   Q8EUL5_MALP2            Unreviewed;       375 AA.
AC   Q8EUL5;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 115.
DE   SubName: Full=Serine/threonine protein kinase {ECO:0000313|EMBL:BAC44697.1};
GN   OrderedLocusNames=MYPE9060 {ECO:0000313|EMBL:BAC44697.1};
OS   Malacoplasma penetrans (strain HF-2) (Mycoplasma penetrans).
OC   Bacteria; Mycoplasmatota; Mycoplasmoidales; Mycoplasmoidaceae;
OC   Malacoplasma.
OX   NCBI_TaxID=272633 {ECO:0000313|EMBL:BAC44697.1, ECO:0000313|Proteomes:UP000002522};
RN   [1] {ECO:0000313|EMBL:BAC44697.1, ECO:0000313|Proteomes:UP000002522}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HF-2 {ECO:0000313|EMBL:BAC44697.1,
RC   ECO:0000313|Proteomes:UP000002522};
RX   PubMed=12466555; DOI=10.1093/nar/gkf667;
RA   Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K.,
RA   Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.;
RT   "The complete genomic sequence of Mycoplasma penetrans, an intracellular
RT   bacterial pathogen in humans.";
RL   Nucleic Acids Res. 30:5293-5300(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR   EMBL; BA000026; BAC44697.1; -; Genomic_DNA.
DR   RefSeq; WP_011077726.1; NC_004432.1.
DR   AlphaFoldDB; Q8EUL5; -.
DR   STRING; 272633.gene:10732028; -.
DR   KEGG; mpe:MYPE9060; -.
DR   eggNOG; COG0515; Bacteria.
DR   HOGENOM; CLU_700090_0_0_14; -.
DR   InParanoid; Q8EUL5; -.
DR   Proteomes; UP000002522; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR045269; Atg1-like.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR24348:SF22; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR   PANTHER; PTHR24348; SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:BAC44697.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002522};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:BAC44697.1};
KW   Transferase {ECO:0000313|EMBL:BAC44697.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        353..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          16..321
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   375 AA;  43182 MW;  8ABD4F2E4E0DDB99 CRC64;
     MKKIDNLVGT TYLNKYKIIK LLGTGGMNST VYLAQNINYN EEDNHLEKFK YVALKFIKRT
     LDTSADNWTK ILDEKVTIGR LMDNPYIVEL ELCFPSSSTS NSIVFSMEYV DGPSLKSLIR
     SRGCLSIVEA LSIFKKIILG VNFMHDRERT IIHRDLKPEN ILLSKDLLDV KISDFGVSSV
     VQNIDDNDYN ILSNEVDVFG TIPYICPDVI GMNKDRPRVT KQFDFHALGI IFYEMIVGEK
     PLEIENEMDP SVITYFKKYD ITPLKKINPK FKNQIENMFL KLTASKSHDI EYRYDDCLQI
     IADIEKIERV ISGQDQEEPL LIPTSKRSYQ FGNSFKISDK KSLQQILLKK PTFWAVSGIV
     LLFLFLLIFS LSIYL
//