Q8EU90 (RNPA_MYCPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein component
Short name=RNase P protein
Short name=RNaseP protein
EC=3.1.26.5

Alternative name(s):
Protein C5

Gene names

Name:	rnpA
Ordered Locus Names:	MYPE10410

Organism

Mycoplasma penetrans (strain HF-2) [Complete proteome] [HAMAP]

Taxonomic identifier

272633 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma penetrans

Protein attributes

Sequence length	111 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme By similarity. HAMAP-Rule MF_00227
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP-Rule MF_00227
Subunit structure	Consists of a catalytic RNA component (M1 or RnpB) and a protein subunit By similarity.
Sequence similarities	Belongs to the RnpA family.

Ontologies

Keywords
Biological process	tRNA processing
Ligand	RNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC tRNA 5'-leader removal Inferred from electronic annotation. Source: HAMAP
Molecular_function	ribonuclease P activity Inferred from electronic annotation. Source: HAMAP tRNA binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 111	111	Ribonuclease P protein component HAMAP-Rule MF_00227		PRO_0000198491

Sequences

	Sequence		Length	Mass (Da)
	Q8EU90 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 17373DC90B25C76C	FASTA	111	13,279
	10 20 30 40 50 60 MKDNVLRNKK DFSNLFKNKS TYYSSFFIIY AYKNNLGWLR YAIAANKKNF KTAVERNKIK 70 80 90 100 110 RQIRSIVRGL ENKNIPVDIL IIPKNNFFKT DFLNKKNDLF NLIVKIRLNI K

References

[1]

"The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans." Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K., Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M. Nucleic Acids Res. 30:5293-5300(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HF-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000026 Genomic DNA. Translation: BAC44826.1.
RefSeq	NP_758422.1. NC_004432.1.
3D structure databases
ProteinModelPortal	Q8EU90.
ModBase	Search...
Protein-protein interaction databases
STRING	272633.MYPE10410.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAC44826; BAC44826; BAC44826.
GeneID	1041063.
KEGG	mpe:MYPE10410.
PATRIC	20021270. VBIMycPen56664_1065.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0594.
KO	K03536.
OMA	RNKIKRE.
Enzyme and pathway databases
BioCyc	MPEN272633:GJBP-1068-MONOMER.
Family and domain databases
Gene3D	3.30.230.10. 1 hit.
HAMAP	MF_00227. RNase_P.
InterPro	IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR000100. RNase_P. IPR020539. RNase_P_CS. [Graphical view]
Pfam	PF00825. Ribonuclease_P. 1 hit. [Graphical view]
ProDom	PD003629. Ribonuclease_P. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00188. rnpA. 1 hit.
PROSITE	PS00648. RIBONUCLEASE_P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNPA_MYCPE

Accession

Primary (citable) accession number: Q8EU90

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program