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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei595For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:OB0235
OrganismiOceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
Taxonomic identifieri221109 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
Proteomesi
  • UP000000822 Componenti: Chromosome

Subcellular locationi

Q8ETM5:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353632 – 600Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST599

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi221109.OB0235.

Structurei

3D structure databases

ProteinModelPortaliQ8ETM5.
SMRiQ8ETM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 217Glutamine amidotransferase type-2UniRule annotationAdd BLAST216
Domaini283 – 422SIS 1UniRule annotationAdd BLAST140
Domaini452 – 590SIS 2UniRule annotationAdd BLAST139

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
HOGENOMiHOG000258896.
KOiK00820.
OMAiASEYRYA.
OrthoDBiPOG091H0061.

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8ETM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGYIGQ NDTKEILLTG LEKLEYRGYD SAGIATLNDN GVHVTKVKGR
60 70 80 90 100
IATLREDVDT TIDSTMGIGH TRWATHGVPS VMNAHPHQST SERFTIVHNG
110 120 130 140 150
VIENYNDIKN EYLADVSFIS ETDTEVIVQL IEKLHEKYQD TKKAFSEAMS
160 170 180 190 200
LLKGSYAIGL IDAEDSETLY VSKNKSPLLV GLGDGFNLVA SDAMATLRET
210 220 230 240 250
DQYLEIFDKE IVLVSRNYVE VQTLDGQVVE RKPFTAEIDA SDTEKGTYPH
260 270 280 290 300
FMLKEIDEQP IVMRKIIQEY QNDNGQLKLD QDIRTAMKDA DRIYIIAAGT
310 320 330 340 350
SYHAGLVGKE FIEKLANIPV EVHVASEFSY NMPLLSEKPL FVFISQSGET
360 370 380 390 400
ADSRAVLVKI KELGHPALTL TNVPGSTLSR EANYTMHLHA GPEIAVASTK
410 420 430 440 450
AYTAQIAVLA ILAVDTARVK GLELDFEPLQ ELAIVANAME VLTDQKEELE
460 470 480 490 500
QLARDYFGTT RNAFFIGRST DYHVAQEAAL KLKEISYIQA EGFAGGELKH
510 520 530 540 550
GTIALIEEGT PVIALTTQEN VNYSIRGNVQ EVVARGANAM VVSMKGLEQD
560 570 580 590 600
EDAFVIPHVH ELLTPLASVI PMQLLAYYAA LHRDCDVDKP RNLAKSVTVE
Length:600
Mass (Da):66,225
Last modified:January 23, 2007 - v3
Checksum:iA182DB39A305324A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000028 Genomic DNA. Translation: BAC12191.1.
RefSeqiWP_011064636.1. NC_004193.1.

Genome annotation databases

EnsemblBacteriaiBAC12191; BAC12191; BAC12191.
KEGGioih:OB0235.

Similar proteinsi

Entry informationi

Entry nameiGLMS_OCEIH
AccessioniPrimary (citable) accession number: Q8ETM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 96 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome