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Q8ESU8

- ECTB_OCEIH

UniProt

Q8ESU8 - ECTB_OCEIH

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Protein

Diaminobutyrate--2-oxoglutarate transaminase

Gene

ectB

Organism
Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.By similarity

Catalytic activityi

L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate.

Cofactori

Pyridoxal phosphate.By similarity

Pathwayi

GO - Molecular functioni

  1. diaminobutyrate-2-oxoglutarate transaminase activity Source: UniProtKB-EC
  2. diaminobutyrate-pyruvate transaminase activity Source: InterPro
  3. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. ectoine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciOIHE221109:GI2A-563-MONOMER.
UniPathwayiUPA00067; UER00121.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminobutyrate--2-oxoglutarate transaminase (EC:2.6.1.76)
Alternative name(s):
DABA aminotransferase
Diaminobutyrate--2-oxoglutarate aminotransferase
L-2,4-diaminobutyric acid transaminase
Gene namesi
Name:ectB
Ordered Locus Names:OB0518
OrganismiOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Taxonomic identifieri221109 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
ProteomesiUP000000822: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Diaminobutyrate--2-oxoglutarate transaminasePRO_0000120526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei274 – 2741N6-(pyridoxal phosphate)lysineSequence Analysis

Interactioni

Protein-protein interaction databases

STRINGi221109.OB0518.

Structurei

3D structure databases

ProteinModelPortaliQ8ESU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0160.
HOGENOMiHOG000020206.
KOiK00836.
OMAiEFDAWQP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR004637. Dat.
IPR012773. Ectoine_EctB.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00709. dat. 1 hit.
TIGR02407. ectoine_ectB. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ESU8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTIVDKARN DMAVFEEMES AVRSYSRGWP VVFEKAKGYK LWDKNGNEYI
60 70 80 90 100
DFFAGAGALN YGHNPSEMQK VMIDYIQNDG VIHSLDMATA PRKKFLESFN
110 120 130 140 150
EIILKPRNMD YKVMFPGPTG TNTVESALKI ARKVTGRDTV IGFTNAFHGM
160 170 180 190 200
TIGSLSVTGN SFKRNGAGIP LNHAISMPFD QYVDEQDSIA YIERFLEDSG
210 220 230 240 250
SGVALPAAFI LETVQGEGGI NAARLEWVKK IEEICRKWDI LLIIDDVQAG
260 270 280 290 300
CGRTGTFFSF EEAGINPDIV CLSKSIGGVG LPMAITLIKP EFDQWGPGEH
310 320 330 340 350
NGTFRGNNLA FLAATEALNN WKTDAFSQNI KKMSSLFQER MKRIVEKFPE
360 370 380 390 400
LNADLRGRGL MLGIGVHVDG LAGEICAEAF SRGLILETSG AKDEVVKFLP
410 420
PLIIDEDGIE KGMDILEESI QAALEK
Length:426
Mass (Da):46,943
Last modified:March 1, 2003 - v1
Checksum:iB966DCD55EB776DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000028 Genomic DNA. Translation: BAC12474.1.
RefSeqiNP_691439.1. NC_004193.1.
WP_011064921.1. NC_004193.1.

Genome annotation databases

EnsemblBacteriaiBAC12474; BAC12474; BAC12474.
GeneIDi1015788.
KEGGioih:OB0518.
PATRICi22791955. VBIOceIhe82024_0530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000028 Genomic DNA. Translation: BAC12474.1 .
RefSeqi NP_691439.1. NC_004193.1.
WP_011064921.1. NC_004193.1.

3D structure databases

ProteinModelPortali Q8ESU8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 221109.OB0518.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC12474 ; BAC12474 ; BAC12474 .
GeneIDi 1015788.
KEGGi oih:OB0518.
PATRICi 22791955. VBIOceIhe82024_0530.

Phylogenomic databases

eggNOGi COG0160.
HOGENOMi HOG000020206.
KOi K00836.
OMAi EFDAWQP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00067 ; UER00121 .
BioCyci OIHE221109:GI2A-563-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProi IPR005814. Aminotrans_3.
IPR004637. Dat.
IPR012773. Ectoine_EctB.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00709. dat. 1 hit.
TIGR02407. ectoine_ectB. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
    Takami H., Takaki Y., Uchiyama I.
    Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Entry informationi

Entry nameiECTB_OCEIH
AccessioniPrimary (citable) accession number: Q8ESU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3