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Protein

Diaminobutyrate--2-oxoglutarate transaminase

Gene

ectB

Organism
Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.By similarity

Catalytic activityi

L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate.

Cofactori

Pathwayi: ectoine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-ectoine from L-aspartate 4-semialdehyde.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Diaminobutyrate--2-oxoglutarate transaminase (ectB)
  2. L-2,4-diaminobutyric acid acetyltransferase (ectA)
  3. L-ectoine synthase (ectC)
This subpathway is part of the pathway ectoine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ectoine from L-aspartate 4-semialdehyde, the pathway ectoine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciOIHE221109:G1G3F-567-MONOMER
UniPathwayiUPA00067; UER00121

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminobutyrate--2-oxoglutarate transaminase (EC:2.6.1.76)
Alternative name(s):
DABA aminotransferase
Diaminobutyrate--2-oxoglutarate aminotransferase
L-2,4-diaminobutyric acid transaminase
Gene namesi
Name:ectB
Ordered Locus Names:OB0518
OrganismiOceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
Taxonomic identifieri221109 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
Proteomesi
  • UP000000822 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001205261 – 426Diaminobutyrate--2-oxoglutarate transaminaseAdd BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei274N6-(pyridoxal phosphate)lysineSequence analysis1

Interactioni

Protein-protein interaction databases

STRINGi221109.OB0518

Structurei

3D structure databases

ProteinModelPortaliQ8ESU8
SMRiQ8ESU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108JPW Bacteria
COG0160 LUCA
HOGENOMiHOG000020206
KOiK00836
OMAiYKVQFTG
OrthoDBiPOG091H066D

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR005814 Aminotrans_3
IPR004637 Dat
IPR012773 Ectoine_EctB
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43552 PTHR43552, 1 hit
PTHR43552:SF2 PTHR43552:SF2, 1 hit
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00709 dat, 1 hit
TIGR02407 ectoine_ectB, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ESU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTIVDKARN DMAVFEEMES AVRSYSRGWP VVFEKAKGYK LWDKNGNEYI
60 70 80 90 100
DFFAGAGALN YGHNPSEMQK VMIDYIQNDG VIHSLDMATA PRKKFLESFN
110 120 130 140 150
EIILKPRNMD YKVMFPGPTG TNTVESALKI ARKVTGRDTV IGFTNAFHGM
160 170 180 190 200
TIGSLSVTGN SFKRNGAGIP LNHAISMPFD QYVDEQDSIA YIERFLEDSG
210 220 230 240 250
SGVALPAAFI LETVQGEGGI NAARLEWVKK IEEICRKWDI LLIIDDVQAG
260 270 280 290 300
CGRTGTFFSF EEAGINPDIV CLSKSIGGVG LPMAITLIKP EFDQWGPGEH
310 320 330 340 350
NGTFRGNNLA FLAATEALNN WKTDAFSQNI KKMSSLFQER MKRIVEKFPE
360 370 380 390 400
LNADLRGRGL MLGIGVHVDG LAGEICAEAF SRGLILETSG AKDEVVKFLP
410 420
PLIIDEDGIE KGMDILEESI QAALEK
Length:426
Mass (Da):46,943
Last modified:March 1, 2003 - v1
Checksum:iB966DCD55EB776DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000028 Genomic DNA Translation: BAC12474.1
RefSeqiWP_011064921.1, NC_004193.1

Genome annotation databases

EnsemblBacteriaiBAC12474; BAC12474; BAC12474
KEGGioih:OB0518

Similar proteinsi

Entry informationi

Entry nameiECTB_OCEIH
AccessioniPrimary (citable) accession number: Q8ESU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health