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Protein

Diaminobutyrate--2-oxoglutarate transaminase

Gene

ectB

Organism
Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.By similarity

Catalytic activityi

L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate.

Cofactori

Pathwayi: ectoine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-ectoine from L-aspartate 4-semialdehyde.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Diaminobutyrate--2-oxoglutarate transaminase (ectB)
  2. L-2,4-diaminobutyric acid acetyltransferase (ectA)
  3. L-ectoine synthase (ectC)
This subpathway is part of the pathway ectoine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ectoine from L-aspartate 4-semialdehyde, the pathway ectoine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00067; UER00121.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminobutyrate--2-oxoglutarate transaminase (EC:2.6.1.76)
Alternative name(s):
DABA aminotransferase
Diaminobutyrate--2-oxoglutarate aminotransferase
L-2,4-diaminobutyric acid transaminase
Gene namesi
Name:ectB
Ordered Locus Names:OB0518
OrganismiOceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
Taxonomic identifieri221109 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
Proteomesi
  • UP000000822 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001205261 – 426Diaminobutyrate--2-oxoglutarate transaminaseAdd BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei274N6-(pyridoxal phosphate)lysineSequence analysis1

Interactioni

Protein-protein interaction databases

STRINGi221109.OB0518.

Structurei

3D structure databases

ProteinModelPortaliQ8ESU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108JPW. Bacteria.
COG0160. LUCA.
HOGENOMiHOG000020206.
KOiK00836.
OMAiGNNHAFI.
OrthoDBiPOG091H066D.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR004637. Dat.
IPR012773. Ectoine_EctB.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00709. dat. 1 hit.
TIGR02407. ectoine_ectB. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ESU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTIVDKARN DMAVFEEMES AVRSYSRGWP VVFEKAKGYK LWDKNGNEYI
60 70 80 90 100
DFFAGAGALN YGHNPSEMQK VMIDYIQNDG VIHSLDMATA PRKKFLESFN
110 120 130 140 150
EIILKPRNMD YKVMFPGPTG TNTVESALKI ARKVTGRDTV IGFTNAFHGM
160 170 180 190 200
TIGSLSVTGN SFKRNGAGIP LNHAISMPFD QYVDEQDSIA YIERFLEDSG
210 220 230 240 250
SGVALPAAFI LETVQGEGGI NAARLEWVKK IEEICRKWDI LLIIDDVQAG
260 270 280 290 300
CGRTGTFFSF EEAGINPDIV CLSKSIGGVG LPMAITLIKP EFDQWGPGEH
310 320 330 340 350
NGTFRGNNLA FLAATEALNN WKTDAFSQNI KKMSSLFQER MKRIVEKFPE
360 370 380 390 400
LNADLRGRGL MLGIGVHVDG LAGEICAEAF SRGLILETSG AKDEVVKFLP
410 420
PLIIDEDGIE KGMDILEESI QAALEK
Length:426
Mass (Da):46,943
Last modified:March 1, 2003 - v1
Checksum:iB966DCD55EB776DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000028 Genomic DNA. Translation: BAC12474.1.
RefSeqiWP_011064921.1. NC_004193.1.

Genome annotation databases

EnsemblBacteriaiBAC12474; BAC12474; BAC12474.
KEGGioih:OB0518.
PATRICi22791955. VBIOceIhe82024_0530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000028 Genomic DNA. Translation: BAC12474.1.
RefSeqiWP_011064921.1. NC_004193.1.

3D structure databases

ProteinModelPortaliQ8ESU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi221109.OB0518.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC12474; BAC12474; BAC12474.
KEGGioih:OB0518.
PATRICi22791955. VBIOceIhe82024_0530.

Phylogenomic databases

eggNOGiENOG4108JPW. Bacteria.
COG0160. LUCA.
HOGENOMiHOG000020206.
KOiK00836.
OMAiGNNHAFI.
OrthoDBiPOG091H066D.

Enzyme and pathway databases

UniPathwayiUPA00067; UER00121.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR004637. Dat.
IPR012773. Ectoine_EctB.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00709. dat. 1 hit.
TIGR02407. ectoine_ectB. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiECTB_OCEIH
AccessioniPrimary (citable) accession number: Q8ESU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.