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Q8ESU8

- ECTB_OCEIH

UniProt

Q8ESU8 - ECTB_OCEIH

Protein

Diaminobutyrate--2-oxoglutarate transaminase

Gene

ectB

Organism
Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.By similarity

    Catalytic activityi

    L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. diaminobutyrate-2-oxoglutarate transaminase activity Source: UniProtKB-EC
    2. diaminobutyrate-pyruvate transaminase activity Source: InterPro
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. ectoine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciOIHE221109:GI2A-563-MONOMER.
    UniPathwayiUPA00067; UER00121.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminobutyrate--2-oxoglutarate transaminase (EC:2.6.1.76)
    Alternative name(s):
    DABA aminotransferase
    Diaminobutyrate--2-oxoglutarate aminotransferase
    L-2,4-diaminobutyric acid transaminase
    Gene namesi
    Name:ectB
    Ordered Locus Names:OB0518
    OrganismiOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
    Taxonomic identifieri221109 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
    ProteomesiUP000000822: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 426426Diaminobutyrate--2-oxoglutarate transaminasePRO_0000120526Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei274 – 2741N6-(pyridoxal phosphate)lysineSequence Analysis

    Interactioni

    Protein-protein interaction databases

    STRINGi221109.OB0518.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ESU8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0160.
    HOGENOMiHOG000020206.
    KOiK00836.
    OMAiEFDAWQP.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    InterProiIPR005814. Aminotrans_3.
    IPR004637. Dat.
    IPR012773. Ectoine_EctB.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00709. dat. 1 hit.
    TIGR02407. ectoine_ectB. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8ESU8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTIVDKARN DMAVFEEMES AVRSYSRGWP VVFEKAKGYK LWDKNGNEYI    50
    DFFAGAGALN YGHNPSEMQK VMIDYIQNDG VIHSLDMATA PRKKFLESFN 100
    EIILKPRNMD YKVMFPGPTG TNTVESALKI ARKVTGRDTV IGFTNAFHGM 150
    TIGSLSVTGN SFKRNGAGIP LNHAISMPFD QYVDEQDSIA YIERFLEDSG 200
    SGVALPAAFI LETVQGEGGI NAARLEWVKK IEEICRKWDI LLIIDDVQAG 250
    CGRTGTFFSF EEAGINPDIV CLSKSIGGVG LPMAITLIKP EFDQWGPGEH 300
    NGTFRGNNLA FLAATEALNN WKTDAFSQNI KKMSSLFQER MKRIVEKFPE 350
    LNADLRGRGL MLGIGVHVDG LAGEICAEAF SRGLILETSG AKDEVVKFLP 400
    PLIIDEDGIE KGMDILEESI QAALEK 426
    Length:426
    Mass (Da):46,943
    Last modified:March 1, 2003 - v1
    Checksum:iB966DCD55EB776DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000028 Genomic DNA. Translation: BAC12474.1.
    RefSeqiNP_691439.1. NC_004193.1.
    WP_011064921.1. NC_004193.1.

    Genome annotation databases

    EnsemblBacteriaiBAC12474; BAC12474; BAC12474.
    GeneIDi1015788.
    KEGGioih:OB0518.
    PATRICi22791955. VBIOceIhe82024_0530.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000028 Genomic DNA. Translation: BAC12474.1 .
    RefSeqi NP_691439.1. NC_004193.1.
    WP_011064921.1. NC_004193.1.

    3D structure databases

    ProteinModelPortali Q8ESU8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 221109.OB0518.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC12474 ; BAC12474 ; BAC12474 .
    GeneIDi 1015788.
    KEGGi oih:OB0518.
    PATRICi 22791955. VBIOceIhe82024_0530.

    Phylogenomic databases

    eggNOGi COG0160.
    HOGENOMi HOG000020206.
    KOi K00836.
    OMAi EFDAWQP.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00067 ; UER00121 .
    BioCyci OIHE221109:GI2A-563-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    InterProi IPR005814. Aminotrans_3.
    IPR004637. Dat.
    IPR012773. Ectoine_EctB.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00709. dat. 1 hit.
    TIGR02407. ectoine_ectB. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
      Takami H., Takaki Y., Uchiyama I.
      Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

    Entry informationi

    Entry nameiECTB_OCEIH
    AccessioniPrimary (citable) accession number: Q8ESU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3