Reviewed, UniProtKB/Swiss-Prot Q8ESS3 (HIS81_OCEIH)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 1
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 1

Gene names

Name:	hisC1
Ordered Locus Names:	OB0545

Organism

Oceanobacillus iheyensis [Complete proteome] [HAMAP]

Taxonomic identifier

182710 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Oceanobacillus

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Histidinol-phosphate aminotransferase 1 HAMAP MF_01023		PRO_0000153407
Amino acid modifications
	Modified residue	209	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8ESS3-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: C01145BE489C966D	FASTA	354	40,160
	10 20 30 40 50 60 MSKFWSSLAK QVDPYIPGEQ LNDDTIIKLN TNENPYPPSN QVIQAIDEAS KNLRLYPSPT 70 80 90 100 110 120 VDELRSEIGE MYGLSQDHIF IGNGSDEVLA FSFMSFFEPG NRIKYPEITY SFYPVYAKLF 130 140 150 160 170 180 NISTDVIPLN DDYTIPVEHF YNSEGGVIFP NPNAPTGIFL EIDQIKRILE NNPNQVVIID 190 200 210 220 230 240 EAYIDFALES AVTLVEAFPN LLVIQTMSKS RSLAGLRIGF AIGNPELIIG LERIKNSFNS 250 260 270 280 290 300 YTVDRLAIAG AIEAIRDKDY FLQTTTKIIE SRSYLKEQLE TRHFDILPSQ ANFLLVSHKE 310 320 330 340 350 VNAEVLYQEL KKQGILVRYF QKPGLENFLR ISIGTPAQIE KLLKKIDHII KPSP

References

[1]

"Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments." Takami H., Takaki Y., Uchiyama I. Nucleic Acids Res. 30:3927-3935(2002) [PubMed: 12235376] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000028 Genomic DNA. Translation: BAC12501.1.
RefSeq	NP_691466.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1015834.
GenomeReviews	Gene locus OB0545 in contig BA000028_GR.
KEGG	oih:OB0545.
NMPDR	fig|221109.1.peg.548.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8ESS3.
OMA	DEQFQIR.
Enzyme and pathway databases
BioCyc	OIHE221109:OB0545-MON.
BRENDA	2.6.1.9. 278212.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS81_OCEIH

Accession

Primary (citable) accession number: Q8ESS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	March 1, 2003
Last modified:	November 3, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)