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Q8ESR8

- HISX_OCEIH

UniProt

Q8ESR8 - HISX_OCEIH

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Protein
Histidinol dehydrogenase
Gene
hisD, OB0551
Organism
Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231NAD By similarity
Binding sitei185 – 1851NAD By similarity
Binding sitei208 – 2081NAD By similarity
Binding sitei231 – 2311Substrate By similarity
Metal bindingi253 – 2531Zinc By similarity
Binding sitei253 – 2531Substrate By similarity
Metal bindingi256 – 2561Zinc By similarity
Binding sitei256 – 2561Substrate By similarity
Active sitei321 – 3211Proton acceptor By similarity
Active sitei322 – 3221Proton acceptor By similarity
Binding sitei322 – 3221Substrate By similarity
Metal bindingi355 – 3551Zinc By similarity
Binding sitei355 – 3551Substrate By similarity
Binding sitei409 – 4091Substrate By similarity
Metal bindingi414 – 4141Zinc By similarity
Binding sitei414 – 4141Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciOIHE221109:GI2A-596-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:OB0551
OrganismiOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Taxonomic identifieri221109 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
ProteomesiUP000000822: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Histidinol dehydrogenaseUniRule annotation
PRO_0000135807Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi221109.OB0551.

Structurei

3D structure databases

ProteinModelPortaliQ8ESR8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ESR8-1 [UniParc]FASTAAdd to Basket

« Hide

MEILSLHQWK QQQDTKSSTI RNKQVDQDVL RIIEQVQIQG DEALKHYTLQ    50
FDQVNLNSFE VTSNEWEQAI KKVDSTLLDA LETAAGNIQR YQSEMLESNW 100
SITPETGVKL GQQVNPLDRV GIYIPGGKAS YPSTVLMDAI PAKVAGVKEI 150
IITSPPNKNG EIDPVVLAAA KIAGVTKVYK VGGAQAIAAL TYGTETIPSV 200
DKIVGPGNIY VTRAKKWVFG DIAIDMIAGP SEICIFADSS APVPYVAADL 250
LSQAEHDEEA SSLCITTDRS FAKLLQEEVN RQIPLLERKE IIEASISQNG 300
KIIICDNNEE AINTINQLAP EHLQLMTIDS EQLCPKIKHA GAIFIGNYSS 350
EPLGDYFAGP SHTLPTNGTA KFSSPLGVYD FVKKTSLIQY SKNKLAEAAD 400
TIITLAEAEG LTAHANAIRI RKENDNA 427
Length:427
Mass (Da):46,545
Last modified:March 1, 2003 - v1
Checksum:i62E9843506AC5F47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000028 Genomic DNA. Translation: BAC12507.1.
RefSeqiNP_691472.1. NC_004193.1.

Genome annotation databases

EnsemblBacteriaiBAC12507; BAC12507; BAC12507.
GeneIDi1015849.
KEGGioih:OB0551.
PATRICi22792025. VBIOceIhe82024_0565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000028 Genomic DNA. Translation: BAC12507.1 .
RefSeqi NP_691472.1. NC_004193.1.

3D structure databases

ProteinModelPortali Q8ESR8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 221109.OB0551.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC12507 ; BAC12507 ; BAC12507 .
GeneIDi 1015849.
KEGGi oih:OB0551.
PATRICi 22792025. VBIOceIhe82024_0565.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci OIHE221109:GI2A-596-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
    Takami H., Takaki Y., Uchiyama I.
    Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Entry informationi

Entry nameiHISX_OCEIH
AccessioniPrimary (citable) accession number: Q8ESR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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