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Protein

Ferrochelatase

Gene

hemH

Organism
Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

Pathwayi: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ferrochelatase (hemH)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi182IronUniRule annotation1
Metal bindingi263IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processHeme biosynthesis, Porphyrin biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciOIHE221109:G1G3F-1248-MONOMER
UniPathwayiUPA00252; UER00325

Names & Taxonomyi

Protein namesi
Recommended name:
FerrochelataseUniRule annotation (EC:4.99.1.1UniRule annotation)
Alternative name(s):
Heme synthaseUniRule annotation
Protoheme ferro-lyaseUniRule annotation
Gene namesi
Name:hemHUniRule annotation
Ordered Locus Names:OB1168
OrganismiOceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
Taxonomic identifieri221109 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
Proteomesi
  • UP000000822 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001751731 – 312FerrochelataseAdd BLAST312

Proteomic databases

PRIDEiQ8ERX9

Interactioni

Protein-protein interaction databases

STRINGi221109.OB1168

Structurei

3D structure databases

ProteinModelPortaliQ8ERX9
SMRiQ8ERX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107TTW Bacteria
COG0276 LUCA
HOGENOMiHOG000060729
KOiK01772
OMAiLGDPYHC
OrthoDBiPOG091H041Q

Family and domain databases

CDDicd00419 Ferrochelatase_C, 1 hit
cd03411 Ferrochelatase_N, 1 hit
HAMAPiMF_00323 Ferrochelatase, 1 hit
InterProiView protein in InterPro
IPR001015 Ferrochelatase
IPR019772 Ferrochelatase_AS
IPR033644 Ferrochelatase_C
IPR033659 Ferrochelatase_N
PANTHERiPTHR11108 PTHR11108, 1 hit
PfamiView protein in Pfam
PF00762 Ferrochelatase, 1 hit
TIGRFAMsiTIGR00109 hemH, 1 hit
PROSITEiView protein in PROSITE
PS00534 FERROCHELATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ERX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKKKIGLLV MAYGTPYKEE DIEPYYTHIR HGRKPDPEAL QDLKERYEAI
60 70 80 90 100
GGISPLAKIT EEQTKALEKK LNANQDQYEF KAYIGLKHIH PFIEDTVEEM
110 120 130 140 150
AKDGIKEAIS LVLAPHYSTF SVKSYNKRAN ETAEKYGIQL DSVEDWYTEP
160 170 180 190 200
GFIKFWADGI KATYAEMTEE ERNNSVLIVS AHSLPEKILK DGDPYKHQLE
210 220 230 240 250
ETAKLIVEEA DVKNYAVGWQ SEGNTPDPWL GPDVQDLTRE LYESEGYKAF
260 270 280 290 300
IYTPVGFVAD HLEVLYDNDY ECKVVCDEIG ASYYRPDMPN VHPEFIETLA
310
NVVMKKAKSE VR
Length:312
Mass (Da):35,760
Last modified:March 1, 2003 - v1
Checksum:iC7D8A9AA9A16D275
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000028 Genomic DNA Translation: BAC13124.1
RefSeqiWP_011065568.1, NC_004193.1

Genome annotation databases

EnsemblBacteriaiBAC13124; BAC13124; BAC13124
KEGGioih:OB1168

Similar proteinsi

Entry informationi

Entry nameiHEMH_OCEIH
AccessioniPrimary (citable) accession number: Q8ERX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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