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Protein

Ferrochelatase

Gene

hemH

Organism
Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

Pathwayi: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ferrochelatase (hemH)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi182 – 1821IronUniRule annotation
Metal bindingi263 – 2631IronUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciOIHE221109:GI2A-1243-MONOMER.
UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
FerrochelataseUniRule annotation (EC:4.99.1.1UniRule annotation)
Alternative name(s):
Heme synthaseUniRule annotation
Protoheme ferro-lyaseUniRule annotation
Gene namesi
Name:hemHUniRule annotation
Ordered Locus Names:OB1168
OrganismiOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Taxonomic identifieri221109 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
Proteomesi
  • UP000000822 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312FerrochelatasePRO_0000175173Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi221109.OB1168.

Structurei

3D structure databases

ProteinModelPortaliQ8ERX9.
SMRiQ8ERX9. Positions 3-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107TTW. Bacteria.
COG0276. LUCA.
HOGENOMiHOG000060729.
OMAiMHKDGIT.
OrthoDBiEOG6XHC5H.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ERX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKKKIGLLV MAYGTPYKEE DIEPYYTHIR HGRKPDPEAL QDLKERYEAI
60 70 80 90 100
GGISPLAKIT EEQTKALEKK LNANQDQYEF KAYIGLKHIH PFIEDTVEEM
110 120 130 140 150
AKDGIKEAIS LVLAPHYSTF SVKSYNKRAN ETAEKYGIQL DSVEDWYTEP
160 170 180 190 200
GFIKFWADGI KATYAEMTEE ERNNSVLIVS AHSLPEKILK DGDPYKHQLE
210 220 230 240 250
ETAKLIVEEA DVKNYAVGWQ SEGNTPDPWL GPDVQDLTRE LYESEGYKAF
260 270 280 290 300
IYTPVGFVAD HLEVLYDNDY ECKVVCDEIG ASYYRPDMPN VHPEFIETLA
310
NVVMKKAKSE VR
Length:312
Mass (Da):35,760
Last modified:March 1, 2003 - v1
Checksum:iC7D8A9AA9A16D275
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000028 Genomic DNA. Translation: BAC13124.1.
RefSeqiWP_011065568.1. NC_004193.1.

Genome annotation databases

EnsemblBacteriaiBAC13124; BAC13124; BAC13124.
PATRICi22793338. VBIOceIhe82024_1186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000028 Genomic DNA. Translation: BAC13124.1.
RefSeqiWP_011065568.1. NC_004193.1.

3D structure databases

ProteinModelPortaliQ8ERX9.
SMRiQ8ERX9. Positions 3-306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi221109.OB1168.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC13124; BAC13124; BAC13124.
PATRICi22793338. VBIOceIhe82024_1186.

Phylogenomic databases

eggNOGiENOG4107TTW. Bacteria.
COG0276. LUCA.
HOGENOMiHOG000060729.
OMAiMHKDGIT.
OrthoDBiEOG6XHC5H.

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.
BioCyciOIHE221109:GI2A-1243-MONOMER.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
    Takami H., Takaki Y., Uchiyama I.
    Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Entry informationi

Entry nameiHEMH_OCEIH
AccessioniPrimary (citable) accession number: Q8ERX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: March 1, 2003
Last modified: January 20, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.