Q8ERS7 (PRPE_OCEIH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase prpE [asymmetrical]
EC=3.6.1.17

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase
Short name=Diadenosine tetraphosphatase

Gene names

Name:	prpE
Ordered Locus Names:	OB1223

Organism

Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831) [Complete proteome] [HAMAP]

Taxonomic identifier

221109 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Oceanobacillus

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Asymmetrically hydrolyzes Ap4p to yield AMP and ATP By similarity. HAMAP MF_01443
Catalytic activity	P1,P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP. HAMAP MF_01443
Cofactor	Nickel By similarity. HAMAP MF_01443
Sequence similarities	Belongs to the prpE family.

Ontologies

Keywords
Ligand	GTP-binding Nickel Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity Inferred from electronic annotation. Source: EC nickel cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 250	250	Bis(5'-nucleosyl)-tetraphosphatase prpE [asymmetrical] HAMAP MF_01443		PRO_0000297705

Sequences

	Sequence		Length	Mass (Da)
	Q8ERS7 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: A679C98248710534	FASTA	250	28,982
	10 20 30 40 50 60 MKIDIIGDVH GCLEELEELL FKLGYQIKNG TYQHSNNRQI VFVGDITDRG PDSIKVIKLV 70 80 90 100 110 120 YQLVKEKLAY YIPGNHCNKL YRFFQGNKVM EKHGLETTTA EYRSLSKEKQ NNIKHKFIEL 130 140 150 160 170 180 YERSPLYLHL KNINVIIAHA GIPEHLIGKK DKRTKTFVLY GDITGEFDTT GKPIRRDWAK 190 200 210 220 230 240 HYHGDSWIVY GHTPVLEPRV VNHTINIDTG CVFGNKLTAY RFPEKEFVSV ASRQPFIAEK 250 FTDFNVSNEH

References

[1]

"Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments." Takami H., Takaki Y., Uchiyama I. Nucleic Acids Res. 30:3927-3935(2002) [PubMed: 12235376] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000028 Genomic DNA. Translation: BAC13179.1.
RefSeq	NP_692144.1. NC_004193.1.
3D structure databases
ProteinModelPortal	Q8ERS7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1017395.
GenomeReviews	Gene locus OB1223 in contig BA000028_GR.
KEGG	oih:OB1223.
NMPDR	fig|221109.1.peg.1222.
PATRIC	22793448. VBIOceIhe82024_1241.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG724457.
OMA	YVPGNHC.
PhylomeDB	Q8ERS7.
Enzyme and pathway databases
BioCyc	OIHE221109:OB1223-MONOMER.
Family and domain databases
HAMAP	MF_01443. PrpE. [Tree]
InterPro	IPR023937. Bis(5'-nucleosyl)-tetraP_PrpE. IPR004843. Metallo_PEstase_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
KO	K01525.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
ProtoNet	Search...

Entry information

Entry name

PRPE_OCEIH

Accession

Primary (citable) accession number: Q8ERS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program