ID   GUAC_OCEIH              Reviewed;         327 AA.
AC   Q8ERJ2;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 39.
DE   RecName: Full=GMP reductase;
DE            EC=1.7.1.7;
DE   AltName: Full=Guanosine 5'-monophosphate oxidoreductase;
DE            Short=Guanosine monophosphate reductase;
GN   Name=guaC; OrderedLocusNames=OB1310;
OS   Oceanobacillus iheyensis.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Oceanobacillus.
OX   NCBI_TaxID=182710;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14371 / JCM 11309 / KCTC 3954 / HTE831;
RX   MEDLINE=22220767; PubMed=12235376; DOI=10.1093/nar/gkf526;
RA   Takami H., Takaki Y., Uchiyama I.;
RT   "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya
RT   Ridge and its unexpected adaptive capabilities to extreme
RT   environments.";
RL   Nucleic Acids Res. 30:3927-3935(2002).
CC   -!- FUNCTION: Catalyzes the irreversible NADPH-dependent deamination
CC       of GMP to IMP. It functions in the conversion of nucleobase,
CC       nucleoside and nucleotide derivatives of G to A nucleotides, and
CC       in maintaining the intracellular balance of A and G nucleotides
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: Inosine 5'-phosphate + NH(3) + NADP(+) =
CC       guanosine 5'-phosphate + NADPH.
CC   -!- SIMILARITY: Belongs to the IMPDH/GMPR family. GuaC type 2
CC       subfamily.
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DR   EMBL; BA000028; BAC13266.1; -; Genomic_DNA.
DR   RefSeq; NP_692231.1; -.
DR   HSSP; P12268; 1B3O.
DR   SMR; Q8ERJ2; 3-320.
DR   GeneID; 1017488; -.
DR   GenomeReviews; BA000028_GR; OB1310.
DR   KEGG; oih:OB1310; -.
DR   NMPDR; fig|221109.1.peg.1314; -.
DR   HOGENOM; Q8ERJ2; -.
DR   OMA; Q8ERJ2; NSRSECD.
DR   BioCyc; OIHE221109:OB1310-MON; -.
DR   BRENDA; 1.7.1.7; 278212.
DR   GO; GO:0003920; F:GMP reductase activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006163; P:purine nucleotide metabolic process; IEA:HAMAP.
DR   HAMAP; MF_01511; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR005994; GMP_reduct2.
DR   InterPro; IPR015875; IMP_DH/GMP_Rdtase_CS.
DR   InterPro; IPR001093; IMP_DH_GMPRt.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF00478; IMPDH; 1.
DR   PIRSF; PIRSF036500; GMP_red_Firmic; 1.
DR   TIGRFAMs; TIGR01306; GMP_reduct_2; 1.
DR   PROSITE; PS00487; IMP_DH_GMP_RED; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    327       GMP reductase.
FT                                /FTId=PRO_0000093762.
FT   NP_BIND     204    227       NADP (By similarity).
FT   ACT_SITE    175    175       Thioimidate intermediate (By similarity).
SQ   SEQUENCE   327 AA;  36203 MW;  F10D02B8A546BAEE CRC64;
     MENVFDYEDI QLIPAKCVVN SRSECDTSVT LGNRTFKLPV VPANMQTIID EKIAKYLAEK
     NYFYIMHRFE PEKRIDFIQD MQEYNLFTSI SVGVKEEEYT FIEDLAAKQL IPDYITIDIA
     HGHSDAVIKM IKHIKNNLPS SFVIAGNVGT PEAVRELENA GADATKVGIG PGKVCITKIK
     TGFGTGGWQL AALRWCAKAA SKPIIADGGI RTHGDIAKSI RFGASMVMIG SLFAGHEESP
     GETIEQDGKK IKEYFGSASE FQKGEKKNVE GKKMYVEHKG PLQDTLTEME QDLQSSISYA
     GGKQLDAIRN VDYVVVKNSI FNGDKVF
//