ID   ROCA_OCEIH              Reviewed;         515 AA.
AC   Q8ERF4;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 38.
DE   RecName: Full=1-pyrroline-5-carboxylate dehydrogenase;
DE            Short=P5C dehydrogenase;
DE            EC=1.5.1.12;
GN   Name=rocA; OrderedLocusNames=OB1349;
OS   Oceanobacillus iheyensis.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Oceanobacillus.
OX   NCBI_TaxID=182710;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14371 / JCM 11309 / KCTC 3954 / HTE831;
RX   MEDLINE=22220767; PubMed=12235376; DOI=10.1093/nar/gkf526;
RA   Takami H., Takaki Y., Uchiyama I.;
RT   "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya
RT   Ridge and its unexpected adaptive capabilities to extreme
RT   environments.";
RL   Nucleic Acids Res. 30:3927-3935(2002).
CC   -!- CATALYTIC ACTIVITY: (S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2
CC       H(2)O = L-glutamate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid degradation; L-proline degradation into L-
CC       glutamate; L-glutamate from L-proline: step 2/2.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. RocA
CC       subfamily.
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DR   EMBL; BA000028; BAC13305.1; -; Genomic_DNA.
DR   RefSeq; NP_692270.1; -.
DR   HSSP; P51977; 1BXS.
DR   GeneID; 1017529; -.
DR   GenomeReviews; BA000028_GR; OB1349.
DR   KEGG; oih:OB1349; -.
DR   NMPDR; fig|221109.1.peg.1355; -.
DR   HOGENOM; Q8ERF4; -.
DR   OMA; Q8ERF4; SINPANT.
DR   BioCyc; OIHE221109:OB1349-MON; -.
DR   BRENDA; 1.5.1.12; 278212.
DR   GO; GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase act...; IEA:HAMAP.
DR   GO; GO:0006537; P:glutamate biosynthetic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00733; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR005932; d-1-pyrroline-5-COlate_DH-2.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR01237; D1pyr5carbox2; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    515       1-pyrroline-5-carboxylate dehydrogenase.
FT                                /FTId=PRO_0000056513.
FT   ACT_SITE    286    286       By similarity.
FT   ACT_SITE    320    320       By similarity.
SQ   SEQUENCE   515 AA;  57295 MW;  14B272164951F531 CRC64;
     MVLPFKHEPF TDFTVKENRK DYQDALAKVK EELGKDYPLV INGEKIYTDD KLISINPSNK
     NEVVGNVSKA TKQHIEEAFT SAKEAFKEWK SWSAEDRARV LYRAAAIVRR RKHEFSAWLS
     YDAGKPWDQA DGDTAEGIDF LEYYARHMVE LEKGKPLADR PNEDNKYFYQ PLGPGVVIPP
     WNFAFAIVCG TTVAPIVAGN PVLLKPSENT PVIAYKLVEV LEEAGLPKGV LNFVPGDPAE
     IGDYLVDHKD THFINFTGSR ATGVRIFERA TKIQDGQTHL KRIVAEMGGK DTIIVDESAD
     LDLAAESIVH SAFGFSGQKC SACSRAVIHE SVYDEVIEKS VELAKTLTVG NPTEDNVYMA
     SVVNQKQFDK IKDYIEVGKQ EGELVFGGET DDNKGFFVHP TIFKDLDPKA RIMQEEIFGP
     VVAFSKAKSF DELLDIANNT EYGLTGAVIS NNRENLNRAQ TEFLVGNLYF NRGCTAAIVG
     YQPFGGFKMS GTDSKAGGPD YLQHFLNAKV VTERF
//