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Q8ER05 (RNC_OCEIH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribonuclease 3
EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Ordered Locus Names:OB1526
OrganismOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831) [Complete proteome] [HAMAP]
Taxonomic identifier221109 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Oceanobacillus ›

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 228228Ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000180417

Regions

Domain3 – 132130RNase III
Domain158 – 22770DRBM

Sites

Active site491 Potential
Active site1211 By similarity
Metal binding451Magnesium By similarity
Metal binding1181Magnesium By similarity
Metal binding1211Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8ER05 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 45463C66B945AF82

FASTA22825,918
        10         20         30         40         50         60 
MDIRPLEEHL GISFQQKALL KEAFTHSSYV NEHRKQRLSD NERLEFLGDA VLELAVSQYL 

        70         80         90        100        110        120 
YRNNKDMPEG EMTKLRAAIV CEPSLKNFAE ELEFGKFLRL GKGEQQTGGR ERPAILADAF 

       130        140        150        160        170        180 
EAFLGALYLD QGFDNVLDFL NIHVFPKLTT GAFSHAMDYK SQLQEFVQQH KDQKIEYRII 

       190        200        210        220 
EEKGPSHNKE FVAEVVIQEK AAGIGTGRTK KEAEQRAAKN ALDSINNS

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References

[1]"Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
Takami H., Takaki Y., Uchiyama I.
Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000028 Genomic DNA. Translation: BAC13482.1.
RefSeqNP_692447.1. NC_004193.1.

3D structure databases

ProteinModelPortalQ8ER05.
ModBaseSearch...

Protein-protein interaction databases

STRING221109.OB1526.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC13482; BAC13482; BAC13482.
GeneID1017802.
KEGGoih:OB1526.
PATRIC22794070. VBIOceIhe82024_1551.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0571.
HOGENOMHOG000246808.
KOK03685.
OMALTHKSCK.

Enzyme and pathway databases

BioCycOIHE221109:GI2A-1616-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR001159. Ds-RNA-bd.
IPR014720. dsRNA-bd-like_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF00636. Ribonuclease_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. RNase_III. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_OCEIH
AccessionPrimary (citable) accession number: Q8ER05
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: March 1, 2003
Last modified: May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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