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Q8EQK9 (GCH4_OCEIH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:OB1688
OrganismOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831) [Complete proteome] [HAMAP]
Taxonomic identifier221109 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Sequence caution

The sequence BAC13644.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000147718

Sites

Site1821May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8EQK9 [UniParc].

Last modified February 1, 2005. Version 2.
Checksum: F340C5AC7A0C2BE6

FASTA30234,148
        10         20         30         40         50         60 
MPKKQLPPKE ERHKLFGSVP PKERTKPIEK NKMADLQNTK RDFLFKLDAV GISNVKYPVI 

        70         80         90        100        110        120 
IHSDLAPKEQ TSIGTFEFSS SIPTMSKGTN MSRFMELLQE YSSSGMNVSI SELKRFTKEL 

       130        140        150        160        170        180 
SGKLEQKDAT IEVSFPWFFE RKGPESQSAG MNHADAKLSV TYDSNSGFSI DVSLSAWITT 

       190        200        210        220        230        240 
LCPCSKEISE YSAHNQRGNV TLEATLVEDF DEAKIDWKLA LLEAAESNAS ARLHPVLKRT 

       250        260        270        280        290        300 
DEKMVTEQAY ENPRFVEDMV RLIAADLYEM PFVSKFHVSC RNEESIHMHD AIASITYDKS 


SE 

« Hide

References

[1]"Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
Takami H., Takaki Y., Uchiyama I.
Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000028 Genomic DNA. Translation: BAC13644.1. Different initiation.
RefSeqNP_692609.1. NC_004193.1.

3D structure databases

ProteinModelPortalQ8EQK9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING221109.OB1688.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC13644; BAC13644; BAC13644.
GeneID1018184.
KEGGoih:OB1688.
PATRIC22794400. VBIOceIhe82024_1716.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OrthoDBEOG6X6RBH.
ProtClustDBPRK13674.

Enzyme and pathway databases

BioCycOIHE221109:GI2A-1767-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00294. TIGR00294. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCH4_OCEIH
AccessionPrimary (citable) accession number: Q8EQK9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: February 19, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways