Q8EQK9 (GCH4_OCEIH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16

Gene names

Name:	folE2
Ordered Locus Names:	OB1688

Organism

Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831) [Complete proteome] [HAMAP]

Taxonomic identifier

221109 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Oceanobacillus › Oceanobacillus iheyensis

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.
Sequence caution	The sequence BAC13644.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	GTP cyclohydrolase folE2 HAMAP-Rule MF_01527		PRO_0000147718
Sites
	Site	182	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8EQK9 [UniParc]. Last modified February 1, 2005. Version 2. Checksum: F340C5AC7A0C2BE6	FASTA	302	34,148
	10 20 30 40 50 60 MPKKQLPPKE ERHKLFGSVP PKERTKPIEK NKMADLQNTK RDFLFKLDAV GISNVKYPVI 70 80 90 100 110 120 IHSDLAPKEQ TSIGTFEFSS SIPTMSKGTN MSRFMELLQE YSSSGMNVSI SELKRFTKEL 130 140 150 160 170 180 SGKLEQKDAT IEVSFPWFFE RKGPESQSAG MNHADAKLSV TYDSNSGFSI DVSLSAWITT 190 200 210 220 230 240 LCPCSKEISE YSAHNQRGNV TLEATLVEDF DEAKIDWKLA LLEAAESNAS ARLHPVLKRT 250 260 270 280 290 300 DEKMVTEQAY ENPRFVEDMV RLIAADLYEM PFVSKFHVSC RNEESIHMHD AIASITYDKS SE

References

[1]

"Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments." Takami H., Takaki Y., Uchiyama I. Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000028 Genomic DNA. Translation: BAC13644.1. Different initiation.
RefSeq	NP_692609.1. NC_004193.1.
3D structure databases
ProteinModelPortal	Q8EQK9.
ModBase	Search...
Protein-protein interaction databases
STRING	221109.OB1688.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAC13644; BAC13644; BAC13644.
GeneID	1018184.
KEGG	oih:OB1688.
PATRIC	22794400. VBIOceIhe82024_1716.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1469.
HOGENOM	HOG000280679.
KO	K09007.
ProtClustDB	PRK13674.
Enzyme and pathway databases
BioCyc	OIHE221109:GI2A-1779-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
Gene3D	3.10.270.10. 1 hit.
HAMAP	MF_01527_B. GTP_cyclohydrol_B.
InterPro	IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00294. TIGR00294. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCH4_OCEIH

Accession

Primary (citable) accession number: Q8EQK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	February 1, 2005
Last modified:	May 1, 2013
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program