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Q8EPB4

- NADK2_OCEIH

UniProt

Q8EPB4 - NADK2_OCEIH

Protein

NAD kinase 2

Gene

nadK2

Organism
Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei51 – 511Proton acceptorUniRule annotation
    Binding sitei150 – 1501NADUniRule annotation
    Binding sitei152 – 1521NADUniRule annotation
    Binding sitei187 – 1871NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi51 – 522NADUniRule annotation
    Nucleotide bindingi123 – 1242NADUniRule annotation
    Nucleotide bindingi163 – 1686NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciOIHE221109:GI2A-2277-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinase 2UniRule annotation
    Gene namesi
    Name:nadK2UniRule annotation
    Ordered Locus Names:OB2196
    OrganismiOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
    Taxonomic identifieri221109 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
    ProteomesiUP000000822: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266NAD kinase 2PRO_0000120643Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi221109.OB2196.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8EPB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000275803.
    KOiK00858.
    OMAiDDLHFET.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8EPB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAERQNIFFY YHPDEEMDGK VKALKKISSE NGLNVVENSS DASIIVSIGG    50
    DGTFLQAVRK TGFRQDCIYT GIMREGQSGL YCDFNIDNFD NMIHSVLHED 100
    LEVRRFPTIK VQINGETPFY CLNEVSIRST IVKTIVINVC VDGFHFETFR 150
    GDGMIVSTPT GSTGYSKSAR GAVIDPLIHG FQVSEVASLN NNQYRTLGSS 200
    FLLNKDRKLE LEILQDGNDH PIISLDNEAS PIKRIQNIDV TMDETIIKTV 250
    KLKNNSYWER VKRTFL 266
    Length:266
    Mass (Da):30,030
    Last modified:March 1, 2003 - v1
    Checksum:iFCF1BD5DF6AB442C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000028 Genomic DNA. Translation: BAC14152.1.
    RefSeqiNP_693117.1. NC_004193.1.

    Genome annotation databases

    EnsemblBacteriaiBAC14152; BAC14152; BAC14152.
    GeneIDi1015552.
    KEGGioih:OB2196.
    PATRICi22795434. VBIOceIhe82024_2225.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000028 Genomic DNA. Translation: BAC14152.1 .
    RefSeqi NP_693117.1. NC_004193.1.

    3D structure databases

    ProteinModelPortali Q8EPB4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 221109.OB2196.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC14152 ; BAC14152 ; BAC14152 .
    GeneIDi 1015552.
    KEGGi oih:OB2196.
    PATRICi 22795434. VBIOceIhe82024_2225.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000275803.
    KOi K00858.
    OMAi DDLHFET.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci OIHE221109:GI2A-2277-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
      Takami H., Takaki Y., Uchiyama I.
      Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

    Entry informationi

    Entry nameiNADK2_OCEIH
    AccessioniPrimary (citable) accession number: Q8EPB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3