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Protein

NAD kinase 2

Gene

nadK2

Organism
Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51Proton acceptorUniRule annotation1
Binding sitei150NADUniRule annotation1
Binding sitei152NADUniRule annotation1
Binding sitei187NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 52NADUniRule annotation2
Nucleotide bindingi123 – 124NADUniRule annotation2
Nucleotide bindingi163 – 168NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciOIHE221109:G1G3F-2292-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 2UniRule annotation
Gene namesi
Name:nadK2UniRule annotation
Ordered Locus Names:OB2196
OrganismiOceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
Taxonomic identifieri221109 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
Proteomesi
  • UP000000822 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001206431 – 266NAD kinase 2Add BLAST266

Proteomic databases

PRIDEiQ8EPB4

Interactioni

Protein-protein interaction databases

STRINGi221109.OB2196

Structurei

3D structure databases

ProteinModelPortaliQ8EPB4
SMRiQ8EPB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108KKH Bacteria
COG0061 LUCA
HOGENOMiHOG000275803
KOiK00858
OMAiEVRKYPL
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q8EPB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERQNIFFY YHPDEEMDGK VKALKKISSE NGLNVVENSS DASIIVSIGG
60 70 80 90 100
DGTFLQAVRK TGFRQDCIYT GIMREGQSGL YCDFNIDNFD NMIHSVLHED
110 120 130 140 150
LEVRRFPTIK VQINGETPFY CLNEVSIRST IVKTIVINVC VDGFHFETFR
160 170 180 190 200
GDGMIVSTPT GSTGYSKSAR GAVIDPLIHG FQVSEVASLN NNQYRTLGSS
210 220 230 240 250
FLLNKDRKLE LEILQDGNDH PIISLDNEAS PIKRIQNIDV TMDETIIKTV
260
KLKNNSYWER VKRTFL
Length:266
Mass (Da):30,030
Last modified:March 1, 2003 - v1
Checksum:iFCF1BD5DF6AB442C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000028 Genomic DNA Translation: BAC14152.1
RefSeqiWP_011066590.1, NC_004193.1

Genome annotation databases

EnsemblBacteriaiBAC14152; BAC14152; BAC14152
KEGGioih:OB2196

Similar proteinsi

Entry informationi

Entry nameiNADK2_OCEIH
AccessioniPrimary (citable) accession number: Q8EPB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health