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Protein

Arsenate reductase

Gene

arsC

Organism
Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].UniRule annotation

Catalytic activityi

Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10NucleophileUniRule annotation1
Active sitei82NucleophileUniRule annotation1
Active sitei89NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processArsenical resistance

Enzyme and pathway databases

BioCyciOIHE221109:G1G3F-2524-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenate reductaseUniRule annotation (EC:1.20.4.4UniRule annotation)
Gene namesi
Name:arsCUniRule annotation
Ordered Locus Names:OB2423
OrganismiOceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
Taxonomic identifieri221109 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
Proteomesi
  • UP000000822 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001625221 – 139Arsenate reductaseAdd BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi10 ↔ 82Redox-active; alternateUniRule annotation
Disulfide bondi82 ↔ 89Redox-active; alternateUniRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ8ENQ5

Interactioni

Protein-protein interaction databases

STRINGi221109.OB2423

Structurei

3D structure databases

ProteinModelPortaliQ8ENQ5
SMRiQ8ENQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4108UXE Bacteria
COG0394 LUCA
HOGENOMiHOG000273093
KOiK03741
OMAiSWHKSKA
OrthoDBiPOG091H07DS

Family and domain databases

HAMAPiMF_01624 Arsenate_reduct, 1 hit
InterProiView protein in InterPro
IPR014064 Arsenate_reductase_ArsC
IPR023485 Ptyr_pPase
IPR036196 Ptyr_pPase_sf
PfamiView protein in Pfam
PF01451 LMWPc, 1 hit
SMARTiView protein in SMART
SM00226 LMWPc, 1 hit
SUPFAMiSSF52788 SSF52788, 1 hit
TIGRFAMsiTIGR02691 arsC_pI258_fam, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ENQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKIIYFLC TGNSCRSQMA EGWGKKILGE EWDVYSAGIE AHGLNPNAIK
60 70 80 90 100
AMREVDIDIT NQTSDQIDKD ILNKADFVVT LCGDAKDKCP MTPPHVKRDH
110 120 130
WGFEDPAKAQ GTEEEKWTVF QQVRDKIGDR IKVFAKTGE
Length:139
Mass (Da):15,676
Last modified:March 1, 2003 - v1
Checksum:i09F5110ED5E43249
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000028 Genomic DNA Translation: BAC14379.1
RefSeqiWP_011066814.1, NC_004193.1

Genome annotation databases

EnsemblBacteriaiBAC14379; BAC14379; BAC14379
KEGGioih:OB2423

Similar proteinsi

Entry informationi

Entry nameiARSC_OCEIH
AccessioniPrimary (citable) accession number: Q8ENQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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