ID   MTLD_OCEIH              Reviewed;         386 AA.
AC   Q8EN87;
DT   23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 33.
DE   RecName: Full=Mannitol-1-phosphate 5-dehydrogenase;
DE            EC=1.1.1.17;
GN   Name=mtlD; OrderedLocusNames=OB2600;
OS   Oceanobacillus iheyensis.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Oceanobacillus.
OX   NCBI_TaxID=182710;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14371 / JCM 11309 / KCTC 3954 / HTE831;
RX   MEDLINE=22220767; PubMed=12235376; DOI=10.1093/nar/gkf526;
RA   Takami H., Takaki Y., Uchiyama I.;
RT   "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya
RT   Ridge and its unexpected adaptive capabilities to extreme
RT   environments.";
RL   Nucleic Acids Res. 30:3927-3935(2002).
CC   -!- CATALYTIC ACTIVITY: D-mannitol 1-phosphate + NAD(+) = D-fructose
CC       6-phosphate + NADH.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family.
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DR   EMBL; BA000028; BAC14556.1; -; Genomic_DNA.
DR   RefSeq; NP_693521.1; -.
DR   GeneID; 1017095; -.
DR   GenomeReviews; BA000028_GR; OB2600.
DR   KEGG; oih:OB2600; -.
DR   NMPDR; fig|221109.1.peg.2599; -.
DR   HOGENOM; Q8EN87; -.
DR   OMA; Q8EN87; VDRIVPN.
DR   BioCyc; OIHE221109:OB2600-MON; -.
DR   BRENDA; 1.1.1.17; 278212.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0008926; F:mannitol-1-phosphate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00196; -; 1.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR000669; Mannitol_DH_core.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   PROSITE; PS00974; MANNITOL_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    386       Mannitol-1-phosphate 5-dehydrogenase.
FT                                /FTId=PRO_0000170714.
FT   NP_BIND       4     15       NAD (By similarity).
SQ   SEQUENCE   386 AA;  43089 MW;  151842F9E829C594 CRC64;
     MKTAVHFGAG NIGRGFIGLL LYQSGYQTIF IDVNNQVIDE INKQKSYHVY LAGKEKQELT
     VNHITGINSI KEPDAVTEAI VKADVVTTAV GPTILPVIAK AISKGLQERT KQNNSPLNII
     ACENMVGGSS LLKEHVFESL EAHKIGEFDR LYGFPDAAVD RIVPNQTNKN LLDVMVEPYY
     EWVVEKKKIV GEVPPIFGIT YVDDLAPYIE RKLFTVNTGH AIPAYLGTHL GYDTIVEAMK
     DLRIDDTIYG ALAESGEALI HAYGFNREMH QEYVSKIIQR FQNPYISDDV KRVARGPIRK
     LGAKDRLVKP ALMYIEYTGK IPVYLAKTIA AALLFNNDED REAIELQKKI SATGYQQAFV
     EVSGCDSDSI LTKKVIEQLR LLQNKK
//