Reviewed, UniProtKB/Swiss-Prot Q8EN87 (MTLD_OCEIH)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	OB2600

Organism

Oceanobacillus iheyensis [Complete proteome] [HAMAP]

Taxonomic identifier

182710 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Oceanobacillus

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 386	386	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_0000170714
Regions
	Nucleotide binding	4 – 15	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8EN87-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 151842F9E829C594	FASTA	386	43,089
	10 20 30 40 50 60 MKTAVHFGAG NIGRGFIGLL LYQSGYQTIF IDVNNQVIDE INKQKSYHVY LAGKEKQELT 70 80 90 100 110 120 VNHITGINSI KEPDAVTEAI VKADVVTTAV GPTILPVIAK AISKGLQERT KQNNSPLNII 130 140 150 160 170 180 ACENMVGGSS LLKEHVFESL EAHKIGEFDR LYGFPDAAVD RIVPNQTNKN LLDVMVEPYY 190 200 210 220 230 240 EWVVEKKKIV GEVPPIFGIT YVDDLAPYIE RKLFTVNTGH AIPAYLGTHL GYDTIVEAMK 250 260 270 280 290 300 DLRIDDTIYG ALAESGEALI HAYGFNREMH QEYVSKIIQR FQNPYISDDV KRVARGPIRK 310 320 330 340 350 360 LGAKDRLVKP ALMYIEYTGK IPVYLAKTIA AALLFNNDED REAIELQKKI SATGYQQAFV 370 380 EVSGCDSDSI LTKKVIEQLR LLQNKK

References

[1]

"Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments." Takami H., Takaki Y., Uchiyama I. Nucleic Acids Res. 30:3927-3935(2002) [PubMed: 12235376] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000028 Genomic DNA. Translation: BAC14556.1.
RefSeq	NP_693521.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1017095.
GenomeReviews	Gene locus OB2600 in contig BA000028_GR.
KEGG	oih:OB2600.
NMPDR	fig|221109.1.peg.2599.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG568825.
OMA	VDRIVPN.
Enzyme and pathway databases
BioCyc	OIHE221109:OB2600-MONOMER.
BRENDA	1.1.1.17. 278212.
Family and domain databases
HAMAP	MF_00196. Mannitol_dehydrog. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_OCEIH

Accession

Primary (citable) accession number: Q8EN87

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	March 1, 2003
Last modified:	January 19, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)