Q8EMP4 (ARAA_OCEIH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	OB2797

Organism

Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831) [Complete proteome] [HAMAP]

Taxonomic identifier

221109 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Oceanobacillus

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.
Sequence caution	The sequence BAC14753.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	L-arabinose isomerase HAMAP MF_00519		PRO_0000198391
Sites
	Metal binding	306	1	Manganese By similarity
	Metal binding	331	1	Manganese By similarity
	Metal binding	348	1	Manganese By similarity
	Metal binding	447	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8EMP4 [UniParc]. Last modified October 31, 2006. Version 2. Checksum: 86B0C87FF8F967B0	FASTA	474	53,283
	10 20 30 40 50 60 MLTLKEKEFW FVVGSQQLYG EEALQEVKAQ AQTVTDALNE SGALPYPIVL KDLAINADQI 70 80 90 100 110 120 TNVMKEVNYR DEVAGVITWM HTFSPAKMWI RGTKLLQKPL LHLATQFNES IPWDTIDMDF 130 140 150 160 170 180 MNLNQSAHGD REYGFINARL NKQNKVVVGY WGKSEVQRQI AEWMDVAAAY NESFNVKVAR 190 200 210 220 230 240 FGDNMRNVAV TDGDKIEAQI QFGWTVDYFA IGDLVQYVNA VKEEEIDVLF AEYKDSYDFD 250 260 270 280 290 300 YGDYSKDDWE ASVRVQASYE IAIKRFLDDG GYNAFTSNFE DLYGMKQLPG LAVQRLMGQG 310 320 330 340 350 360 YGFAGEGDWK TAALDRLLKV MSHNQSTGFM EDYTYELAEG KEAILQSHML EVDPTLASTK 370 380 390 400 410 420 PKITVFPLGI GDREDPARLV FDGKAGDGVV VSMADFGTHF KLLINEVNAF EPTTPAPNLP 430 440 450 460 470 VARVLWEVKP NFQDGVKAWI ENGGGHHTVV SLNLTTDQVV SYAKLVGLDY IVIK

References

[1]

"Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments." Takami H., Takaki Y., Uchiyama I. Nucleic Acids Res. 30:3927-3935(2002) [PubMed: 12235376] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000028 Genomic DNA. Translation: BAC14753.1. Different initiation.
RefSeq	NP_693719.1. NC_004193.1.
3D structure databases
ProteinModelPortal	Q8EMP4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1016968.
GenomeReviews	Gene locus OB2797 in contig BA000028_GR.
KEGG	oih:OB2797.
NMPDR	fig|221109.1.peg.2799.
PATRIC	22796672. VBIOceIhe82024_2840.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG297198.
PhylomeDB	Q8EMP4.
ProtClustDB	PRK02929.
Enzyme and pathway databases
BioCyc	OIHE221109:OB2797-MONOMER.
BRENDA	5.3.1.4. 4380.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA_OCEIH

Accession

Primary (citable) accession number: Q8EMP4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2003
Last sequence update:	October 31, 2006
Last modified:	January 25, 2012
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program