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Q8ELI2 (ALF1_OCEIH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase class 1
EC=4.1.2.13
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name=FBP aldolase
Gene names
Name:fda
Ordered Locus Names:OB3245
OrganismOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831) [Complete proteome] [HAMAP]
Taxonomic identifier221109 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Oceanobacillus ›

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. HAMAP-Rule MF_00729

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. HAMAP-Rule MF_00729

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Fructose-bisphosphate aldolase class 1 HAMAP-Rule MF_00729
PRO_0000216901

Sites

Active site1761Proton acceptor By similarity
Active site2131Schiff-base intermediate with dihydroxyacetone-P By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8ELI2 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 76B018EE93174698

FASTA29432,819
        10         20         30         40         50         60 
MNQKQLEQMK TSKGFIAALD QSGGSTPKAL AAYGIPEDSY NNEDEMFDLV HEMRTRIITS 

        70         80         90        100        110        120 
KAFDSDSIIG AILFEQTMDR EIEGMYTGDY LAEKKGIVPF LKVDKGLAEE TNGVQLMKPI 

       130        140        150        160        170        180 
DNLDETLRRA NERNIFGTKM RSVIKQANPK AIKEVVDQQF DIGKKIIAAG LVPIIEPEVD 

       190        200        210        220        230        240 
IHSPEKEKCE DLLKAEIINH LNQLSEDENV MLKLTIPTKK NLYKELIDHP RVVRVVALSG 

       250        260        270        280        290 
GYSTDVANEK LKENNGLIAS FSRALSQDLN ADQSDEDFNL ALEKAVKSIY DASV

« Hide

References

[1]"Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
Takami H., Takaki Y., Uchiyama I.
Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000028 Genomic DNA. Translation: BAC15201.1.
RefSeqNP_694167.1. NC_004193.1.

3D structure databases

ProteinModelPortalQ8ELI2.
SMRQ8ELI2. Positions 1-294.
ModBaseSearch...

Protein-protein interaction databases

STRING221109.OB3245.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC15201; BAC15201; BAC15201.
GeneID1016498.
KEGGoih:OB3245.
PATRIC22797586. VBIOceIhe82024_3297.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3588.
HOGENOMHOG000073502.
KOK01623.
OMAGTKMRSV.
ProtClustDBPRK05377.

Enzyme and pathway databases

BioCycOIHE221109:GI2A-3334-MONOMER.
UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00729. FBP_aldolase_1.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
IPR023014. FBP_aldolase_I_bac.
[Graphical view]
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEPS00158. ALDOLASE_CLASS_I. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALF1_OCEIH
AccessionPrimary (citable) accession number: Q8ELI2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: March 1, 2003
Last modified: May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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