Q8ELI2 (ALF1_OCEIH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-bisphosphate aldolase class 1
EC=4.1.2.13

Alternative name(s):
Fructose-biphosphate aldolase class I
Short name=FBP aldolase

Gene names

Name:	fda
Ordered Locus Names:	OB3245

Organism

Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831) [Complete proteome] [HAMAP]

Taxonomic identifier

221109 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Oceanobacillus

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. HAMAP MF_00729
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. HAMAP MF_00729
Sequence similarities	Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Fructose-bisphosphate aldolase class 1 HAMAP MF_00729		PRO_0000216901
Sites
	Active site	176	1	Proton acceptor By similarity
	Active site	213	1	Schiff-base intermediate with dihydroxyacetone-P By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8ELI2 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 76B018EE93174698	FASTA	294	32,819
	10 20 30 40 50 60 MNQKQLEQMK TSKGFIAALD QSGGSTPKAL AAYGIPEDSY NNEDEMFDLV HEMRTRIITS 70 80 90 100 110 120 KAFDSDSIIG AILFEQTMDR EIEGMYTGDY LAEKKGIVPF LKVDKGLAEE TNGVQLMKPI 130 140 150 160 170 180 DNLDETLRRA NERNIFGTKM RSVIKQANPK AIKEVVDQQF DIGKKIIAAG LVPIIEPEVD 190 200 210 220 230 240 IHSPEKEKCE DLLKAEIINH LNQLSEDENV MLKLTIPTKK NLYKELIDHP RVVRVVALSG 250 260 270 280 290 GYSTDVANEK LKENNGLIAS FSRALSQDLN ADQSDEDFNL ALEKAVKSIY DASV

References

[1]

"Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments." Takami H., Takaki Y., Uchiyama I. Nucleic Acids Res. 30:3927-3935(2002) [PubMed: 12235376] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000028 Genomic DNA. Translation: BAC15201.1.
RefSeq	NP_694167.1. NC_004193.1.
3D structure databases
ProteinModelPortal	Q8ELI2.
SMR	Q8ELI2. Positions 1-294.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1016498.
GenomeReviews	Gene locus OB3245 in contig BA000028_GR.
KEGG	oih:OB3245.
NMPDR	fig|221109.1.peg.3247.
PATRIC	22797586. VBIOceIhe82024_3297.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG307137.
OMA	GTKMRSV.
ProtClustDB	PRK05377.
Enzyme and pathway databases
BioCyc	OIHE221109:OB3245-MONOMER.
Family and domain databases
HAMAP	MF_00729. FBP_aldolase_1. [Tree]
InterPro	IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. IPR023014. FBP_aldolase_I_bac. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01623.
Pfam	PF00274. Glycolytic. 1 hit. [Graphical view]
PROSITE	PS00158. ALDOLASE_CLASS_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALF1_OCEIH

Accession

Primary (citable) accession number: Q8ELI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program