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Q8EL95

- MT36_OCEIH

UniProt

Q8EL95 - MT36_OCEIH

Protein

Putative modification methylase OB3336

Gene

OB3336

Organism
Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence ACCGGT, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by a specific endonuclease.Curated

    Catalytic activityi

    S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei97 – 971PROSITE-ProRule annotation

    GO - Molecular functioni

    1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
    2. DNA binding Source: InterPro

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciOIHE221109:GI2A-3427-MONOMER.

    Protein family/group databases

    REBASEi6390. M.OihORF3336P.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative modification methylase OB3336 (EC:2.1.1.37)
    Alternative name(s):
    Cytosine-specific methyltransferase
    M.OihORF3336P
    Gene namesi
    Ordered Locus Names:OB3336
    OrganismiOceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
    Taxonomic identifieri221109 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeOceanobacillus
    ProteomesiUP000000822: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 460460Putative modification methylase OB3336PRO_0000087915Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi221109.OB3336.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8EL95.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 458444SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
    Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0270.
    HOGENOMiHOG000225505.
    KOiK00558.
    OMAiFRQIGNS.
    OrthoDBiEOG6KMB5M.

    Family and domain databases

    Gene3Di3.40.50.150. 2 hits.
    InterProiIPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10629. PTHR10629. 1 hit.
    PfamiPF00145. DNA_methylase. 1 hit.
    [Graphical view]
    PRINTSiPR00105. C5METTRFRASE.
    SUPFAMiSSF53335. SSF53335. 2 hits.
    TIGRFAMsiTIGR00675. dcm. 1 hit.
    PROSITEiPS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8EL95-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHQIYSATST DKKLPEVVDL FSGCGGLALG FQLAGFNIRK GIELDRDASD    50
    VASFNLHWRQ GKHDRHLNND ITLLSANEFY NDLDRKNDLI VIGGPPCQAY 100
    SKIGRAKLKS LGEERRQEND ARGKLYENFL DYALHVDANV IVMENVPEAV 150
    NYGGVNIPDT VCDILINKGY DAIWTVLNAA DFGVPQTRVR LFVMAIKKDI 200
    GKIKFIPEPT HKPHINVKRQ SVNVRWMQSE IRNSKYYKQP NIPDETLSDW 250
    VTVGDAIGDL PNLFPVYNQK YKNYKPMMMK EYKSPPQNTF QKLMRINNKV 300
    DKVTGNMFRN TKRDFSIFDK MEEGDNYLDA HNIAMSLLRK EMRKSGITKE 350
    NEFEYRLLKD RIVPPYSTEK FVEKWRKLSS DKPSHTLVAH LSTDTYSHLH 400
    PREPRGISVR EAARLQSFPD DFLFDCSMGA AFKQIGNAVP PLLAKAIAEA 450
    MKKNIQGGCI 460
    Length:460
    Mass (Da):52,508
    Last modified:March 1, 2003 - v1
    Checksum:i5483B86933CDBD0C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000028 Genomic DNA. Translation: BAC15292.1.
    RefSeqiNP_694258.1. NC_004193.1.

    Genome annotation databases

    EnsemblBacteriaiBAC15292; BAC15292; BAC15292.
    GeneIDi1018006.
    KEGGioih:OB3336.
    PATRICi22797780. VBIOceIhe82024_3394.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000028 Genomic DNA. Translation: BAC15292.1 .
    RefSeqi NP_694258.1. NC_004193.1.

    3D structure databases

    ProteinModelPortali Q8EL95.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 221109.OB3336.

    Protein family/group databases

    REBASEi 6390. M.OihORF3336P.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC15292 ; BAC15292 ; BAC15292 .
    GeneIDi 1018006.
    KEGGi oih:OB3336.
    PATRICi 22797780. VBIOceIhe82024_3394.

    Phylogenomic databases

    eggNOGi COG0270.
    HOGENOMi HOG000225505.
    KOi K00558.
    OMAi FRQIGNS.
    OrthoDBi EOG6KMB5M.

    Enzyme and pathway databases

    BioCyci OIHE221109:GI2A-3427-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 2 hits.
    InterProi IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10629. PTHR10629. 1 hit.
    Pfami PF00145. DNA_methylase. 1 hit.
    [Graphical view ]
    PRINTSi PR00105. C5METTRFRASE.
    SUPFAMi SSF53335. SSF53335. 2 hits.
    TIGRFAMsi TIGR00675. dcm. 1 hit.
    PROSITEi PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge and its unexpected adaptive capabilities to extreme environments."
      Takami H., Takaki Y., Uchiyama I.
      Nucleic Acids Res. 30:3927-3935(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14371 / JCM 11309 / KCTC 3954 / HTE831.

    Entry informationi

    Entry nameiMT36_OCEIH
    AccessioniPrimary (citable) accession number: Q8EL95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 30, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3