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Protein

Cytochrome c-type biogenesis protein CcmE

Gene

ccmE

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei131Heme (covalent; via pros nitrogen)By similarity1
Metal bindingi135Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCytochrome c-type biogenesis
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSONE211586:G1GMP-248-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type biogenesis protein CcmE
Alternative name(s):
Cytochrome c maturation protein E
Heme chaperone CcmE
Gene namesi
Name:ccmE
Synonyms:cycJ
Ordered Locus Names:SO_0259
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini30 – 161PeriplasmicSequence analysisAdd BLAST132

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002388641 – 161Cytochrome c-type biogenesis protein CcmEAdd BLAST161

Proteomic databases

PaxDbiQ8EK44

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_0259

Structurei

Secondary structure

1161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni40 – 46Combined sources7
Turni48 – 51Combined sources4
Beta strandi52 – 54Combined sources3
Beta strandi59 – 66Combined sources8
Beta strandi80 – 85Combined sources6
Beta strandi92 – 96Combined sources5
Helixi101 – 103Combined sources3
Beta strandi106 – 116Combined sources11
Beta strandi121 – 128Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J6QNMR-A30-161[»]
1LM0NMR-A30-161[»]
ProteinModelPortaliQ8EK44
SMRiQ8EK44
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8EK44

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmE/CycJ family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108ZKK Bacteria
COG2332 LUCA
HOGENOMiHOG000009661
KOiK02197
OMAiHVEFAVH
OrthoDBiPOG091H05S8
PhylomeDBiQ8EK44

Family and domain databases

HAMAPiMF_01959 CcmE, 1 hit
InterProiView protein in InterPro
IPR004329 CcmE
IPR036127 CcmE-like_sf
PANTHERiPTHR34128 PTHR34128, 1 hit
PfamiView protein in Pfam
PF03100 CcmE, 1 hit
SUPFAMiSSF82093 SSF82093, 1 hit

Sequencei

Sequence statusi: Complete.

Q8EK44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPRRKKRLT LAVALIGGVA AIASLLLYAL NSNLNLFYTP SEIVNGKTDT
60 70 80 90 100
GVKPEAGQRI RVGGMVTVGS MVRDPNSLHV QFAVHDSLGG EILVTYDDLL
110 120 130 140 150
PDLFREGQGI VAQGVLGEDG KLAATEVLAK HDENYMPPEV AEAMGQKHEK
160
LDYSQQKSAT Q
Length:161
Mass (Da):17,358
Last modified:March 1, 2003 - v1
Checksum:i9B7FB4604F2A0629
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044582 Genomic DNA Translation: AAC02697.1
AE014299 Genomic DNA Translation: AAN53344.1
RefSeqiNP_715899.1, NC_004347.2
WP_011070633.1, NC_004347.2

Genome annotation databases

EnsemblBacteriaiAAN53344; AAN53344; SO_0259
GeneIDi1168143
KEGGison:SO_0259
PATRICifig|211586.12.peg.250

Similar proteinsi

Entry informationi

Entry nameiCCME_SHEON
AccessioniPrimary (citable) accession number: Q8EK44
Secondary accession number(s): O52690
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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