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Protein

Cytochrome c-type biogenesis protein CcmE

Gene

ccmE

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei131Heme (covalent; via pros nitrogen)By similarity1
Metal bindingi135Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type biogenesis protein CcmE
Alternative name(s):
Cytochrome c maturation protein E
Heme chaperone CcmE
Gene namesi
Name:ccmE
Synonyms:cycJ
Ordered Locus Names:SO_0259
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini30 – 161PeriplasmicSequence analysisAdd BLAST132

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002388641 – 161Cytochrome c-type biogenesis protein CcmEAdd BLAST161

Proteomic databases

PaxDbiQ8EK44.

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_0259.

Structurei

Secondary structure

1161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni40 – 46Combined sources7
Turni48 – 51Combined sources4
Beta strandi52 – 54Combined sources3
Beta strandi59 – 66Combined sources8
Beta strandi80 – 85Combined sources6
Beta strandi92 – 96Combined sources5
Helixi101 – 103Combined sources3
Beta strandi106 – 116Combined sources11
Beta strandi121 – 128Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J6QNMR-A30-161[»]
1LM0NMR-A30-161[»]
ProteinModelPortaliQ8EK44.
SMRiQ8EK44.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8EK44.

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmE/CycJ family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108ZKK. Bacteria.
COG2332. LUCA.
HOGENOMiHOG000009661.
KOiK02197.
OMAiHVEFAVH.
OrthoDBiPOG091H05S8.
PhylomeDBiQ8EK44.

Family and domain databases

HAMAPiMF_01959. CcmE. 1 hit.
InterProiIPR004329. CcmE.
[Graphical view]
PfamiPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMiSSF82093. SSF82093. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8EK44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPRRKKRLT LAVALIGGVA AIASLLLYAL NSNLNLFYTP SEIVNGKTDT
60 70 80 90 100
GVKPEAGQRI RVGGMVTVGS MVRDPNSLHV QFAVHDSLGG EILVTYDDLL
110 120 130 140 150
PDLFREGQGI VAQGVLGEDG KLAATEVLAK HDENYMPPEV AEAMGQKHEK
160
LDYSQQKSAT Q
Length:161
Mass (Da):17,358
Last modified:March 1, 2003 - v1
Checksum:i9B7FB4604F2A0629
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044582 Genomic DNA. Translation: AAC02697.1.
AE014299 Genomic DNA. Translation: AAN53344.1.
RefSeqiNP_715899.1. NC_004347.2.
WP_011070633.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN53344; AAN53344; SO_0259.
GeneIDi1168143.
KEGGison:SO_0259.
PATRICi23520217. VBISheOne101494_0250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044582 Genomic DNA. Translation: AAC02697.1.
AE014299 Genomic DNA. Translation: AAN53344.1.
RefSeqiNP_715899.1. NC_004347.2.
WP_011070633.1. NC_004347.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J6QNMR-A30-161[»]
1LM0NMR-A30-161[»]
ProteinModelPortaliQ8EK44.
SMRiQ8EK44.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi211586.SO_0259.

Proteomic databases

PaxDbiQ8EK44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN53344; AAN53344; SO_0259.
GeneIDi1168143.
KEGGison:SO_0259.
PATRICi23520217. VBISheOne101494_0250.

Phylogenomic databases

eggNOGiENOG4108ZKK. Bacteria.
COG2332. LUCA.
HOGENOMiHOG000009661.
KOiK02197.
OMAiHVEFAVH.
OrthoDBiPOG091H05S8.
PhylomeDBiQ8EK44.

Miscellaneous databases

EvolutionaryTraceiQ8EK44.

Family and domain databases

HAMAPiMF_01959. CcmE. 1 hit.
InterProiIPR004329. CcmE.
[Graphical view]
PfamiPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMiSSF82093. SSF82093. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCME_SHEON
AccessioniPrimary (citable) accession number: Q8EK44
Secondary accession number(s): O52690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.