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Protein

Dihydrolipoyl dehydrogenase

Gene

lpdA

Organism
Shewanella oneidensis (strain MR-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Name:lpdAImported
Ordered Locus Names:SO_0426Imported
OrganismiShewanella oneidensis (strain MR-1)Imported
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_0426.

Structurei

3D structure databases

ProteinModelPortaliQ8EJN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

HOGENOMiHOG000276708.
KOiK00382.
OMAiKFTGPNS.
OrthoDBiEOG6QCD6D.
PhylomeDBiQ8EJN7.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
InterProiIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR012999. Pyr_OxRdtase_I_AS.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamiPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8EJN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNEIKTQVV VLGAGPAGYS AAFRAADLGL ETVIVERFST LGGVCLNVGC
60 70 80 90 100
IPSKALLHVA KVIEEAKAVA AHGVVFGEPT IDLDKLRSFK QKVISQLTGG
110 120 130 140 150
LGGMSKMRKV NVVNGFGKFS GPNSLEVTAE DGTVTVVKFD QAIIAAGSRP
160 170 180 190 200
IKLPFIPHED PRIWDSTDAL ELKEVPGKLL VMGGGIIGLE MGTVYSSLGS
210 220 230 240 250
EIDVVEMFDQ VIPAADKDVV RVFTKQIKKK FNLILETKVT AVEAREDGIY
260 270 280 290 300
VSMEGKSAPA EPVRYDAVLV AIGRTPNGKL IDAEKAGVKI DERGFINVDK
310 320 330 340 350
QLRTNVPHIY AIGDIVGQPM LAHKGVHEGH VAAEVIAGMK HYFDPKVIPS
360 370 380 390 400
IAYTDPEVAW VGLTEKEAKE QGIAYETATF PWAASGRAIA SDCSEGMTKL
410 420 430 440 450
IFDKDTHRVI GGAIVGVNGG ELLGEIGLAI EMGCDAEDLA LTIHAHPTLH
460 470
ESVGLAAEIY EGSITDLPNP KAKKK
Length:475
Mass (Da):50,536
Last modified:March 1, 2003 - v1
Checksum:iBEF4C86CB40C87C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA. Translation: AAN53508.1.
RefSeqiNP_716063.1. NC_004347.2.
WP_011070784.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN53508; AAN53508; SO_0426.
GeneIDi1168304.
KEGGison:SO_0426.
PATRICi23520553. VBISheOne101494_0415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA. Translation: AAN53508.1.
RefSeqiNP_716063.1. NC_004347.2.
WP_011070784.1. NC_004347.2.

3D structure databases

ProteinModelPortaliQ8EJN7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi211586.SO_0426.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN53508; AAN53508; SO_0426.
GeneIDi1168304.
KEGGison:SO_0426.
PATRICi23520553. VBISheOne101494_0415.

Phylogenomic databases

HOGENOMiHOG000276708.
KOiK00382.
OMAiKFTGPNS.
OrthoDBiEOG6QCD6D.
PhylomeDBiQ8EJN7.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
InterProiIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR012999. Pyr_OxRdtase_I_AS.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamiPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1Imported.

Entry informationi

Entry nameiQ8EJN7_SHEON
AccessioniPrimary (citable) accession number: Q8EJN7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.