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Q8EJN7

- Q8EJN7_SHEON

UniProt

Q8EJN7 - Q8EJN7_SHEON

Protein

Dihydrolipoyl dehydrogenase

Gene

lpdA

Organism
Shewanella oneidensis (strain MR-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

    Cofactori

    Binds 1 FAD per subunit.UniRule annotation
    Binds 1 FAD per subunit By similarity.

    GO - Molecular functioni

    1. dihydrolipoyl dehydrogenase activity Source: UniProtKB-EC
    2. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Ligandi

    FADUniRule annotation, Flavoprotein, NADUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
    Gene namesi
    Name:lpdAImported
    Ordered Locus Names:SO_0426Imported
    OrganismiShewanella oneidensis (strain MR-1)Imported
    Taxonomic identifieri211586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000008186: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi211586.SO_0426.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8EJN7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active centerUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000276708.
    KOiK00382.
    OMAiEIAWVGV.
    OrthoDBiEOG6QCD6D.
    PhylomeDBiQ8EJN7.

    Family and domain databases

    Gene3Di3.30.390.30. 1 hit.
    InterProiIPR016156. FAD/NAD-linked_Rdtase_dimer.
    IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR006258. Lipoamide_DH.
    IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR012999. Pyr_OxRdtase_I_AS.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    [Graphical view]
    PfamiPF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    PF02852. Pyr_redox_dim. 1 hit.
    [Graphical view]
    PRINTSiPR00368. FADPNR.
    SUPFAMiSSF55424. SSF55424. 1 hit.
    TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
    PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8EJN7-1 [UniParc]FASTAAdd to Basket

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    MSNEIKTQVV VLGAGPAGYS AAFRAADLGL ETVIVERFST LGGVCLNVGC    50
    IPSKALLHVA KVIEEAKAVA AHGVVFGEPT IDLDKLRSFK QKVISQLTGG 100
    LGGMSKMRKV NVVNGFGKFS GPNSLEVTAE DGTVTVVKFD QAIIAAGSRP 150
    IKLPFIPHED PRIWDSTDAL ELKEVPGKLL VMGGGIIGLE MGTVYSSLGS 200
    EIDVVEMFDQ VIPAADKDVV RVFTKQIKKK FNLILETKVT AVEAREDGIY 250
    VSMEGKSAPA EPVRYDAVLV AIGRTPNGKL IDAEKAGVKI DERGFINVDK 300
    QLRTNVPHIY AIGDIVGQPM LAHKGVHEGH VAAEVIAGMK HYFDPKVIPS 350
    IAYTDPEVAW VGLTEKEAKE QGIAYETATF PWAASGRAIA SDCSEGMTKL 400
    IFDKDTHRVI GGAIVGVNGG ELLGEIGLAI EMGCDAEDLA LTIHAHPTLH 450
    ESVGLAAEIY EGSITDLPNP KAKKK 475
    Length:475
    Mass (Da):50,536
    Last modified:March 1, 2003 - v1
    Checksum:iBEF4C86CB40C87C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN53508.1.
    RefSeqiNP_716063.1. NC_004347.2.
    WP_011070784.1. NC_004347.2.

    Genome annotation databases

    EnsemblBacteriaiAAN53508; AAN53508; SO_0426.
    GeneIDi1168304.
    KEGGison:SO_0426.
    PATRICi23520553. VBISheOne101494_0415.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN53508.1 .
    RefSeqi NP_716063.1. NC_004347.2.
    WP_011070784.1. NC_004347.2.

    3D structure databases

    ProteinModelPortali Q8EJN7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 211586.SO_0426.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN53508 ; AAN53508 ; SO_0426 .
    GeneIDi 1168304.
    KEGGi son:SO_0426.
    PATRICi 23520553. VBISheOne101494_0415.

    Phylogenomic databases

    HOGENOMi HOG000276708.
    KOi K00382.
    OMAi EIAWVGV.
    OrthoDBi EOG6QCD6D.
    PhylomeDBi Q8EJN7.

    Family and domain databases

    Gene3Di 3.30.390.30. 1 hit.
    InterProi IPR016156. FAD/NAD-linked_Rdtase_dimer.
    IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR006258. Lipoamide_DH.
    IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR012999. Pyr_OxRdtase_I_AS.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    [Graphical view ]
    Pfami PF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    PF02852. Pyr_redox_dim. 1 hit.
    [Graphical view ]
    PRINTSi PR00368. FADPNR.
    SUPFAMi SSF55424. SSF55424. 1 hit.
    TIGRFAMsi TIGR01350. lipoamide_DH. 1 hit.
    PROSITEi PS00076. PYRIDINE_REDOX_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MR-1Imported.

    Entry informationi

    Entry nameiQ8EJN7_SHEON
    AccessioniPrimary (citable) accession number: Q8EJN7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    The active site is a redox-active disulfide bond.UniRule annotation
    The active site is a redox-active disulfide bond By similarity.

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3