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Protein

Dihydrolipoyl dehydrogenase

Gene

lpdA

Organism
Shewanella oneidensis (strain MR-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Catalytic activityi

Protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Name:lpdAImported
Ordered Locus Names:SO_0426Imported
OrganismiShewanella oneidensis (strain MR-1)Imported
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PaxDbiQ8EJN7.

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_0426.

Structurei

3D structure databases

ProteinModelPortaliQ8EJN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 329FAD/NAD-binding_domInterPro annotationAdd BLAST322
Domaini348 – 456Pyr_redox_dimInterPro annotationAdd BLAST109

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiTMSEAVM.
OrthoDBiPOG091H0239.
PhylomeDBiQ8EJN7.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer_sf.
IPR006258. Lipoamide_DH.
IPR001100. Pyr_nuc-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
PfamiView protein in Pfam
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
PIRSFiPIRSF000350. Mercury_reductase_MerA. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiView protein in PROSITE
PS00076. PYRIDINE_REDOX_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8EJN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNEIKTQVV VLGAGPAGYS AAFRAADLGL ETVIVERFST LGGVCLNVGC
60 70 80 90 100
IPSKALLHVA KVIEEAKAVA AHGVVFGEPT IDLDKLRSFK QKVISQLTGG
110 120 130 140 150
LGGMSKMRKV NVVNGFGKFS GPNSLEVTAE DGTVTVVKFD QAIIAAGSRP
160 170 180 190 200
IKLPFIPHED PRIWDSTDAL ELKEVPGKLL VMGGGIIGLE MGTVYSSLGS
210 220 230 240 250
EIDVVEMFDQ VIPAADKDVV RVFTKQIKKK FNLILETKVT AVEAREDGIY
260 270 280 290 300
VSMEGKSAPA EPVRYDAVLV AIGRTPNGKL IDAEKAGVKI DERGFINVDK
310 320 330 340 350
QLRTNVPHIY AIGDIVGQPM LAHKGVHEGH VAAEVIAGMK HYFDPKVIPS
360 370 380 390 400
IAYTDPEVAW VGLTEKEAKE QGIAYETATF PWAASGRAIA SDCSEGMTKL
410 420 430 440 450
IFDKDTHRVI GGAIVGVNGG ELLGEIGLAI EMGCDAEDLA LTIHAHPTLH
460 470
ESVGLAAEIY EGSITDLPNP KAKKK
Length:475
Mass (Da):50,536
Last modified:March 1, 2003 - v1
Checksum:iBEF4C86CB40C87C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA. Translation: AAN53508.1.
RefSeqiNP_716063.1. NC_004347.2.
WP_011070784.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN53508; AAN53508; SO_0426.
GeneIDi1168304.
KEGGison:SO_0426.
PATRICifig|211586.12.peg.415.

Similar proteinsi

Entry informationi

Entry nameiQ8EJN7_SHEON
AccessioniPrimary (citable) accession number: Q8EJN7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported