Q8EJN7 (Q8EJN7_SHEON) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydrolipoyl dehydrogenase RuleBase RU003692
EC=1.8.1.4 RuleBase RU003692

Gene names

Name:	lpdA EMBL AAN53508.1
Ordered Locus Names:	SO_0426 EMBL AAN53508.1

Organism

Shewanella oneidensis (strain MR-1) [Reference proteome] [HAMAP] EMBL AAN53508.1

Taxonomic identifier

211586 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella › Shewanella oneidensis

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH. RuleBase RU003692
Cofactor	Binds 1 FAD per subunit By similarity. RuleBase RU003692
Miscellaneous	The active site is a redox-active disulfide bond By similarity. RuleBase RU003692
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. RuleBase RU003691

Ontologies

Keywords
Domain	Redox-active center RuleBase RU003691
Ligand	FAD RuleBase RU003691 Flavoprotein RuleBase RU003691 NAD RuleBase RU003692
Molecular function	Oxidoreductase RuleBase RU003691 EMBL AAN53508.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	dihydrolipoyl dehydrogenase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8EJN7 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: BEF4C86CB40C87C5	FASTA	475	50,536
	10 20 30 40 50 60 MSNEIKTQVV VLGAGPAGYS AAFRAADLGL ETVIVERFST LGGVCLNVGC IPSKALLHVA 70 80 90 100 110 120 KVIEEAKAVA AHGVVFGEPT IDLDKLRSFK QKVISQLTGG LGGMSKMRKV NVVNGFGKFS 130 140 150 160 170 180 GPNSLEVTAE DGTVTVVKFD QAIIAAGSRP IKLPFIPHED PRIWDSTDAL ELKEVPGKLL 190 200 210 220 230 240 VMGGGIIGLE MGTVYSSLGS EIDVVEMFDQ VIPAADKDVV RVFTKQIKKK FNLILETKVT 250 260 270 280 290 300 AVEAREDGIY VSMEGKSAPA EPVRYDAVLV AIGRTPNGKL IDAEKAGVKI DERGFINVDK 310 320 330 340 350 360 QLRTNVPHIY AIGDIVGQPM LAHKGVHEGH VAAEVIAGMK HYFDPKVIPS IAYTDPEVAW 370 380 390 400 410 420 VGLTEKEAKE QGIAYETATF PWAASGRAIA SDCSEGMTKL IFDKDTHRVI GGAIVGVNGG 430 440 450 460 470 ELLGEIGLAI EMGCDAEDLA LTIHAHPTLH ESVGLAAEIY EGSITDLPNP KAKKK

References

[1]

"Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis." Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C., Read T.D., Eisen J.A., Seshadri R., Ward N.L., Methe B.A., Clayton R.A., Meyer T., Tsapin A., Scott J., Beanan M.J., Brinkac L.M., Daugherty S.C., DeBoy R.T. , Dodson R.J., Durkin A.S., Haft D.H., Kolonay J.F., Madupu R., Peterson J.D., Umayam L.A., White O., Wolf A.M., Vamathevan J.J., Weidman J.F., Impraim M., Lee K., Berry K.J., Lee C., Mueller J., Khouri H.M., Gill J., Utterback T.R., McDonald L.A., Feldblyum T.V., Smith H.O., Venter J.C., Nealson K.H., Fraser C.M. Nat. Biotechnol. 20:1118-1123(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MR-1 EMBL AAN53508.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014299 Genomic DNA. Translation: AAN53508.1.
RefSeq	NP_716063.1. NC_004347.2.
3D structure databases
HSSP	HSSP built from PDB template 1OJT based on UniProtKB Q51225.
ProteinModelPortal	Q8EJN7.
ModBase	Search...
Protein-protein interaction databases
STRING	211586.SO_0426.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN53508; AAN53508; SO_0426.
GeneID	1168304.
KEGG	son:SO_0426.
PATRIC	23520553. VBISheOne101494_0415.
Phylogenomic databases
HOGENOM	HOG000276708.
KO	K00382.
OMA	GMAAEIY.
ProtClustDB	PRK06467.
Family and domain databases
Gene3D	3.30.390.30. 1 hit.
InterPro	IPR016156. FAD/NAD-linked_Rdtase_dimer. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR006258. Lipoamide_DH. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR012999. Pyr_OxRdtase_I_AS. IPR001327. Pyr_OxRdtase_NAD-bd_dom. [Graphical view]
PANTHER	PTHR22912:SF20. PTHR22912:SF20. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR.
SUPFAM	SSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
TIGRFAMs	TIGR01350. lipoamide_DH. 1 hit.
PROSITE	PS00076. PYRIDINE_REDOX_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8EJN7_SHEON

Accession

Primary (citable) accession number: Q8EJN7

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)