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Q8EJN7

- Q8EJN7_SHEON

UniProt

Q8EJN7 - Q8EJN7_SHEON

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Protein

Dihydrolipoyl dehydrogenase

Gene

lpdA

Organism
Shewanella oneidensis (strain MR-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyl dehydrogenase activity Source: UniProtKB-EC
  2. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Name:lpdAImported
Ordered Locus Names:SO_0426Imported
OrganismiShewanella oneidensis (strain MR-1)Imported
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_0426.

Structurei

3D structure databases

ProteinModelPortaliQ8EJN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

HOGENOMiHOG000276708.
KOiK00382.
OMAiEIAWVGV.
OrthoDBiEOG6QCD6D.
PhylomeDBiQ8EJN7.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
InterProiIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR012999. Pyr_OxRdtase_I_AS.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamiPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.
SUPFAMiSSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8EJN7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNEIKTQVV VLGAGPAGYS AAFRAADLGL ETVIVERFST LGGVCLNVGC
60 70 80 90 100
IPSKALLHVA KVIEEAKAVA AHGVVFGEPT IDLDKLRSFK QKVISQLTGG
110 120 130 140 150
LGGMSKMRKV NVVNGFGKFS GPNSLEVTAE DGTVTVVKFD QAIIAAGSRP
160 170 180 190 200
IKLPFIPHED PRIWDSTDAL ELKEVPGKLL VMGGGIIGLE MGTVYSSLGS
210 220 230 240 250
EIDVVEMFDQ VIPAADKDVV RVFTKQIKKK FNLILETKVT AVEAREDGIY
260 270 280 290 300
VSMEGKSAPA EPVRYDAVLV AIGRTPNGKL IDAEKAGVKI DERGFINVDK
310 320 330 340 350
QLRTNVPHIY AIGDIVGQPM LAHKGVHEGH VAAEVIAGMK HYFDPKVIPS
360 370 380 390 400
IAYTDPEVAW VGLTEKEAKE QGIAYETATF PWAASGRAIA SDCSEGMTKL
410 420 430 440 450
IFDKDTHRVI GGAIVGVNGG ELLGEIGLAI EMGCDAEDLA LTIHAHPTLH
460 470
ESVGLAAEIY EGSITDLPNP KAKKK
Length:475
Mass (Da):50,536
Last modified:March 1, 2003 - v1
Checksum:iBEF4C86CB40C87C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN53508.1.
RefSeqiNP_716063.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN53508; AAN53508; SO_0426.
GeneIDi1168304.
KEGGison:SO_0426.
PATRICi23520553. VBISheOne101494_0415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN53508.1 .
RefSeqi NP_716063.1. NC_004347.2.

3D structure databases

ProteinModelPortali Q8EJN7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 211586.SO_0426.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN53508 ; AAN53508 ; SO_0426 .
GeneIDi 1168304.
KEGGi son:SO_0426.
PATRICi 23520553. VBISheOne101494_0415.

Phylogenomic databases

HOGENOMi HOG000276708.
KOi K00382.
OMAi EIAWVGV.
OrthoDBi EOG6QCD6D.
PhylomeDBi Q8EJN7.

Family and domain databases

Gene3Di 3.30.390.30. 1 hit.
InterProi IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR012999. Pyr_OxRdtase_I_AS.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view ]
Pfami PF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view ]
PRINTSi PR00368. FADPNR.
SUPFAMi SSF55424. SSF55424. 1 hit.
TIGRFAMsi TIGR01350. lipoamide_DH. 1 hit.
PROSITEi PS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1Imported.

Entry informationi

Entry nameiQ8EJN7_SHEON
AccessioniPrimary (citable) accession number: Q8EJN7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3