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Q8EJM1

- PUR9_SHEON

UniProt

Q8EJM1 - PUR9_SHEON

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, SO_0442
Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:SO_0442
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_0000192121Add
BLAST

Proteomic databases

PRIDEiQ8EJM1.

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_0442.

Structurei

3D structure databases

ProteinModelPortaliQ8EJM1.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.
PhylomeDBiQ8EJM1.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8EJM1-1 [UniParc]FASTAAdd to Basket

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MTVANHARPI RRALLSVSDK TGILEFAKAL HAQGVELLST GGTARLLADN    50
GVPVIEVSDY TGHPEIMDGR VKTLHPKVHG GILARRGLDE NVMAANNINA 100
IDLVAVNLYP FADTVAKAGC TLEDAIENID IGGPTMVRAA AKNHKDVTIV 150
VNAADYNRVL AEMAVNNGST THATRFDLAI AAFEHTAGYD GMIANYFGTM 200
VPMHRVPAHS TDECFQDSLS VEGSKFPRTF NTQLVKKQDL RYGENSHQAA 250
AFYVDTKIDE ASVATAVQLQ GKALSYNNIA DTDAALECVK EFSEPACVIV 300
KHANPCGVAL GKDLLDAYNR AYQTDPTSAF GGIIAFNGEL DAATASAIVE 350
RQFVEVIIAP VVSQGARDVV AKKTNVRLLE CGQWNTKTQT LDYKRVNGGL 400
LVQDRDQGMV GLDDIKVVTK RQPTESELKD LMFCWKVAKF VKSNAIVYAK 450
DGMTIGVGAG QMSRVYSAKI AGIKAADEGL EVVNSVMASD AFFPFRDGID 500
AAAAAGISCI IQPGGSMRDA EIIAAADEHG MAMVMTGMRH FRH 543
Length:543
Mass (Da):58,221
Last modified:March 1, 2003 - v1
Checksum:i7A6AB5179A4D961E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN53524.1.
RefSeqiNP_716079.1. NC_004347.2.
WP_011070798.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN53524; AAN53524; SO_0442.
GeneIDi1168318.
KEGGison:SO_0442.
PATRICi23520585. VBISheOne101494_0431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN53524.1 .
RefSeqi NP_716079.1. NC_004347.2.
WP_011070798.1. NC_004347.2.

3D structure databases

ProteinModelPortali Q8EJM1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 211586.SO_0442.

Proteomic databases

PRIDEi Q8EJM1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN53524 ; AAN53524 ; SO_0442 .
GeneIDi 1168318.
KEGGi son:SO_0442.
PATRICi 23520585. VBISheOne101494_0431.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.
PhylomeDBi Q8EJM1.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1.

Entry informationi

Entry nameiPUR9_SHEON
AccessioniPrimary (citable) accession number: Q8EJM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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