SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8EJA7

- FTHS_SHEON

UniProt

Q8EJA7 - FTHS_SHEON

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Formate--tetrahydrofolate ligase
Gene
fhs, SO_0560
Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:SO_0560
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199373Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_0560.

Structurei

3D structure databases

ProteinModelPortaliQ8EJA7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.
PhylomeDBiQ8EJA7.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8EJA7-1 [UniParc]FASTAAdd to Basket

« Hide

MLTDMEISRR AHLKDIAQLG AEFGLLPEEM QLFGNTKAKV DLQVQQRLAG    50
QPKGKLIIVT AVTPTPHGEG KTVTTIGLTQ SLKALGNKVC ACIRQPSMGP 100
VFGVKGGAAG GGYAQVVPMQ ELNLHLTGDI HAVSSAHNLG AAAIASRLYH 150
EMRLGKAEFE RQSGLSYLDI DPKGIRWHRV VDHNDRCLRE IEVGLGENNG 200
PAYTSGFDIT AASELMAILA LSRNLTDMRV RIGKLVLALN RQGEAVSADE 250
LGVAGAMTAI MADAVKPTLM QTLNGAPCLI HAGPFANIAH GNSSVIADDI 300
ALKLADFVVT EGGFGSDMGF EKFCNIKARQ SGLIPSAAVL VTTLKALKAN 350
SGLASDTDIN APDQARLEAG FANLNWHINN VVQYGLPVVV AINRFASDTD 400
AELNWLMEAV RGTAAFGCEL SEAFSQGEDG AMALAQTVIR ACEQPSEFRL 450
LYPDNMELEA KLSTLAELGY GAAGINLSAV AKQQLQELSA LGYAHLPVCM 500
AKTPLSISHD PQLKGVPQGF IVPVRELVLN AGAGFITALV GNVMTMPGLG 550
LTPGYLKIDI DVDGEIIGLG 570
Length:570
Mass (Da):60,232
Last modified:March 1, 2003 - v1
Checksum:iCD7C2D1DA2626AEB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN53641.1.
RefSeqiNP_716196.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN53641; AAN53641; SO_0560.
GeneIDi1168429.
KEGGison:SO_0560.
PATRICi23520802. VBISheOne101494_0539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN53641.1 .
RefSeqi NP_716196.1. NC_004347.2.

3D structure databases

ProteinModelPortali Q8EJA7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 211586.SO_0560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN53641 ; AAN53641 ; SO_0560 .
GeneIDi 1168429.
KEGGi son:SO_0560.
PATRICi 23520802. VBISheOne101494_0539.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.
PhylomeDBi Q8EJA7.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1.

Entry informationi

Entry nameiFTHS_SHEON
AccessioniPrimary (citable) accession number: Q8EJA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi