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Q8EJA7 (FTHS_SHEON) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:SO_0560
OrganismShewanella oneidensis (strain MR-1) [Reference proteome] [HAMAP]
Taxonomic identifier211586 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199373

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8EJA7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: CD7C2D1DA2626AEB

FASTA57060,232
        10         20         30         40         50         60 
MLTDMEISRR AHLKDIAQLG AEFGLLPEEM QLFGNTKAKV DLQVQQRLAG QPKGKLIIVT 

        70         80         90        100        110        120 
AVTPTPHGEG KTVTTIGLTQ SLKALGNKVC ACIRQPSMGP VFGVKGGAAG GGYAQVVPMQ 

       130        140        150        160        170        180 
ELNLHLTGDI HAVSSAHNLG AAAIASRLYH EMRLGKAEFE RQSGLSYLDI DPKGIRWHRV 

       190        200        210        220        230        240 
VDHNDRCLRE IEVGLGENNG PAYTSGFDIT AASELMAILA LSRNLTDMRV RIGKLVLALN 

       250        260        270        280        290        300 
RQGEAVSADE LGVAGAMTAI MADAVKPTLM QTLNGAPCLI HAGPFANIAH GNSSVIADDI 

       310        320        330        340        350        360 
ALKLADFVVT EGGFGSDMGF EKFCNIKARQ SGLIPSAAVL VTTLKALKAN SGLASDTDIN 

       370        380        390        400        410        420 
APDQARLEAG FANLNWHINN VVQYGLPVVV AINRFASDTD AELNWLMEAV RGTAAFGCEL 

       430        440        450        460        470        480 
SEAFSQGEDG AMALAQTVIR ACEQPSEFRL LYPDNMELEA KLSTLAELGY GAAGINLSAV 

       490        500        510        520        530        540 
AKQQLQELSA LGYAHLPVCM AKTPLSISHD PQLKGVPQGF IVPVRELVLN AGAGFITALV 

       550        560        570 
GNVMTMPGLG LTPGYLKIDI DVDGEIIGLG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014299 Genomic DNA. Translation: AAN53641.1.
RefSeqNP_716196.1. NC_004347.2.

3D structure databases

ProteinModelPortalQ8EJA7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING211586.SO_0560.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN53641; AAN53641; SO_0560.
GeneID1168429.
KEGGson:SO_0560.
PATRIC23520802. VBISheOne101494_0539.

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13506.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_SHEON
AccessionPrimary (citable) accession number: Q8EJA7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways