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Q8EJA7

- FTHS_SHEON

UniProt

Q8EJA7 - FTHS_SHEON

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:SO_0560
    OrganismiShewanella oneidensis (strain MR-1)
    Taxonomic identifieri211586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000008186: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Formate--tetrahydrofolate ligasePRO_0000199373Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi211586.SO_0560.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8EJA7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.
    PhylomeDBiQ8EJA7.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8EJA7-1 [UniParc]FASTAAdd to Basket

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    MLTDMEISRR AHLKDIAQLG AEFGLLPEEM QLFGNTKAKV DLQVQQRLAG    50
    QPKGKLIIVT AVTPTPHGEG KTVTTIGLTQ SLKALGNKVC ACIRQPSMGP 100
    VFGVKGGAAG GGYAQVVPMQ ELNLHLTGDI HAVSSAHNLG AAAIASRLYH 150
    EMRLGKAEFE RQSGLSYLDI DPKGIRWHRV VDHNDRCLRE IEVGLGENNG 200
    PAYTSGFDIT AASELMAILA LSRNLTDMRV RIGKLVLALN RQGEAVSADE 250
    LGVAGAMTAI MADAVKPTLM QTLNGAPCLI HAGPFANIAH GNSSVIADDI 300
    ALKLADFVVT EGGFGSDMGF EKFCNIKARQ SGLIPSAAVL VTTLKALKAN 350
    SGLASDTDIN APDQARLEAG FANLNWHINN VVQYGLPVVV AINRFASDTD 400
    AELNWLMEAV RGTAAFGCEL SEAFSQGEDG AMALAQTVIR ACEQPSEFRL 450
    LYPDNMELEA KLSTLAELGY GAAGINLSAV AKQQLQELSA LGYAHLPVCM 500
    AKTPLSISHD PQLKGVPQGF IVPVRELVLN AGAGFITALV GNVMTMPGLG 550
    LTPGYLKIDI DVDGEIIGLG 570
    Length:570
    Mass (Da):60,232
    Last modified:March 1, 2003 - v1
    Checksum:iCD7C2D1DA2626AEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN53641.1.
    RefSeqiNP_716196.1. NC_004347.2.

    Genome annotation databases

    EnsemblBacteriaiAAN53641; AAN53641; SO_0560.
    GeneIDi1168429.
    KEGGison:SO_0560.
    PATRICi23520802. VBISheOne101494_0539.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN53641.1 .
    RefSeqi NP_716196.1. NC_004347.2.

    3D structure databases

    ProteinModelPortali Q8EJA7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 211586.SO_0560.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN53641 ; AAN53641 ; SO_0560 .
    GeneIDi 1168429.
    KEGGi son:SO_0560.
    PATRICi 23520802. VBISheOne101494_0539.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.
    PhylomeDBi Q8EJA7.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MR-1.

    Entry informationi

    Entry nameiFTHS_SHEON
    AccessioniPrimary (citable) accession number: Q8EJA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3