ID   ASTD_SHEON              Reviewed;         487 AA.
AC   Q8EJ54;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 51.
DE   RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase;
DE            EC=1.2.1.71;
DE   AltName: Full=Succinylglutamic semialdehyde dehydrogenase;
DE            Short=SGSD;
GN   Name=astD; OrderedLocusNames=SO_0619;
OS   Shewanella oneidensis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=70863;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MR-1;
RX   MEDLINE=22297686; PubMed=12368813; DOI=10.1038/nbt749;
RA   Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C.,
RA   Read T.D., Eisen J.A., Seshadri R., Ward N.L., Methe B.A.,
RA   Clayton R.A., Meyer T., Tsapin A., Scott J., Beanan M.J.,
RA   Brinkac L.M., Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S.,
RA   Haft D.H., Kolonay J.F., Madupu R., Peterson J.D., Umayam L.A.,
RA   White O., Wolf A.M., Vamathevan J.J., Weidman J.F., Impraim M.,
RA   Lee K., Berry K.J., Lee C., Mueller J., Khouri H.M., Gill J.,
RA   Utterback T.R., McDonald L.A., Feldblyum T.V., Smith H.O.,
RA   Venter J.C., Nealson K.H., Fraser C.M.;
RT   "Genome sequence of the dissimilatory metal ion-reducing bacterium
RT   Shewanella oneidensis.";
RL   Nat. Biotechnol. 20:1118-1123(2002).
CC   -!- FUNCTION: Catalyzes the NAD-dependent reduction of
CC       succinylglutamate semialdehyde into succinylglutamate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD(+)
CC       + H(2)O = N-succinyl-L-glutamate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC       pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC       subfamily.
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DR   EMBL; AE014299; AAN53697.1; -; Genomic_DNA.
DR   RefSeq; NP_716252.1; -.
DR   HSSP; P51977; 1BXS.
DR   GeneID; 1168485; -.
DR   GenomeReviews; AE014299_GR; SO_0619.
DR   KEGG; son:SO_0619; -.
DR   NMPDR; fig|211586.1.peg.580; -.
DR   TIGR; SO_0619; -.
DR   HOGENOM; Q8EJ54; -.
DR   OMA; Q8EJ54; SSRTGHL.
DR   BioCyc; SONE211586:SO_0619-MON; -.
DR   BRENDA; 1.2.1.71; 257422.
DR   GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenas...; IEA:EC.
DR   GO; GO:0019544; P:arginine catabolic process to glutamate; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01174; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR03240; arg_catab_astD; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    487       N-succinylglutamate 5-semialdehyde
FT                                dehydrogenase.
FT                                /FTId=PRO_0000262426.
FT   NP_BIND     220    225       NAD (By similarity).
FT   ACT_SITE    243    243       By similarity.
FT   ACT_SITE    277    277       By similarity.
SQ   SEQUENCE   487 AA;  51611 MW;  5215B02398E25232 CRC64;
     MTHFIKGQWH TGKGHDVASS NPANGEIIWR GQTATAEQVN AAVDAAREAQ FDWFILGFDA
     RLKIVEAYRS QLEANKAELA ETIAQETGKP QWETATEVAA MIGKIGLSAS AYNKRTGTET
     NDTPAGRAVL RHKPHGVVAV FGPYNFPGHL PNGHIVPALL AGNSVVFKPS ELTPKVAELM
     VTLWEKSGLP AGVLNLVQGE VDTGKALASH PQLDGLFFTG SSRTGHLLHQ QYAGHPGKIL
     ALEMGGNNPL IIKGVADIKA AVHDILQSAY ISSGQRCTCA RRLYVEQGEQ GDALVAKLVE
     AVKQIKVGPW NAQPQPFMGS MISEAAAKGM VAAQANLLSL GGVPLVELMH LQAGTGLVSP
     GLIDVTAVSE LPDEEYFGPL LQLVRYSDFD QAIKLANQTR YGLSAGILAD SREDYEYFLA
     RIRAGIVNWN KQITGASGAA PFGGVGASGN HRASAFYAAD YCAYPVASVE ADAVSLPATL
     SPGLTLS
//