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Protein

Catalase-peroxidase 2

Gene

katG2

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei103 – 1031Transition state stabilizerUniRule annotation
Active sitei107 – 1071Proton acceptorUniRule annotation
Metal bindingi270 – 2701Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2444. SonCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 2UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 2UniRule annotation
Alternative name(s):
Peroxidase/catalase 2UniRule annotation
Gene namesi
Name:katG2UniRule annotation
Ordered Locus Names:SO_0725
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727UniRule annotationAdd
BLAST
Chaini28 – 741714Catalase-peroxidase 2PRO_0000354921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki106 ↔ 229Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-255)UniRule annotation
Cross-linki229 ↔ 255Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-106)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PaxDbiQ8EIV5.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi211586.SO_0725.

Structurei

3D structure databases

ProteinModelPortaliQ8EIV5.
SMRiQ8EIV5. Positions 31-741.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiMSTRWEK.
OrthoDBiEOG6RRKKM.
PhylomeDBiQ8EIV5.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8EIV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKINTLPTLS ALTLAMSLAL GAGMATAQEQ ATGNQFWWPE KLNLSPLRQN
60 70 80 90 100
AIESNPYGSD YRYAEAFNTL DLDAVKKDIK ALMTESQDWW PADYGHYGPF
110 120 130 140 150
FIRMAWHSAG VYRIFDGRGG AAGGQQRFEP LNSWPADNVS LDKARRLLWP
160 170 180 190 200
IKQKYGSKLS WGDLMVLTGN VALESMGFKT FGFGGGRVDD WEAEMVNWGS
210 220 230 240 250
EKAWLDNKRH NGKGELAKPM GATQMGLIYV NPEGPNGVPD PLASAKEIRD
260 270 280 290 300
TFGRMAMNDE ETVALIAGGH TFGKAHGAHD PAKCVGADPA AAGIEEQGLG
310 320 330 340 350
WKNKCGKGHS EDTVTSGLEG AWSSNPTKWT MEYLTWLYTF DWVQTKSPAG
360 370 380 390 400
HIQWTPADGK AANLVPDAHL PDKRHAPIMF TSDIALKADP IYREITTRFL
410 420 430 440 450
KNPQEFELAF AKAWFKLTHR DLGPKARYLG ADVPAEALIW QDPIPALDHP
460 470 480 490 500
LIDNADIKAL GNKILASGLT VPELVRTAWA SASSFRGTDM RGGANGARIR
510 520 530 540 550
LEPMMNWQAN NPKELAKVLA KLEKVQKDFN GSLKGSKKVS LADVIVLGGS
560 570 580 590 600
VAVEKAAKEA GVVISVPFTP GRMDATQVQT DVNSFAVLEP AADGFRNYYS
610 620 630 640 650
KDSSLSPAEM LIERANMLNL TVPEMTVLVG GLRALDANSA GVKHGVFTDK
660 670 680 690 700
PGVLSNDFFV NLLDMSTKWR KSDKQEGIYE GQDRNSGKLK WTATPVDLIF
710 720 730 740
GSHSELRAVS EVYGAQDGQD RFIQDFVKAW NKVMNADRFD I
Length:741
Mass (Da):81,256
Last modified:March 1, 2003 - v1
Checksum:i2318B8A0E9567F1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA. Translation: AAN53803.1.
RefSeqiNP_716358.1. NC_004347.2.
WP_011071036.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN53803; AAN53803; SO_0725.
GeneIDi1168580.
KEGGison:SO_0725.
PATRICi23521120. VBISheOne101494_0694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA. Translation: AAN53803.1.
RefSeqiNP_716358.1. NC_004347.2.
WP_011071036.1. NC_004347.2.

3D structure databases

ProteinModelPortaliQ8EIV5.
SMRiQ8EIV5. Positions 31-741.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi211586.SO_0725.

Protein family/group databases

PeroxiBasei2444. SonCP01.

Proteomic databases

PaxDbiQ8EIV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN53803; AAN53803; SO_0725.
GeneIDi1168580.
KEGGison:SO_0725.
PATRICi23521120. VBISheOne101494_0694.

Phylogenomic databases

eggNOGiCOG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiMSTRWEK.
OrthoDBiEOG6RRKKM.
PhylomeDBiQ8EIV5.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1.

Entry informationi

Entry nameiKATG2_SHEON
AccessioniPrimary (citable) accession number: Q8EIV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.