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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciSONE211586:G1GMP-733-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:SO_0781
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669361 – 962Glycine dehydrogenase (decarboxylating)Add BLAST962

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei709N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiQ8EIQ6

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi211586.SO_0781

Structurei

3D structure databases

ProteinModelPortaliQ8EIQ6
SMRiQ8EIQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6
PhylomeDBiQ8EIQ6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8EIQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKQTLTQLE QHDLFLRRHI GPDSSQQQEM LNYVGAESLD DLTAQIVPES
60 70 80 90 100
IRLSQELSIG DSCGEAEGIA YIRGLAKQNQ VFKSYIGMGY YGTQVPNVIL
110 120 130 140 150
RNVLENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD
160 170 180 190 200
EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVVKT RAECFGFEVV
210 220 230 240 250
VGPASEAVNH ELFGALFQYS NRFGQITDFT DLFAELRAKN VIVTVAADIM
260 270 280 290 300
SLVLLKSPGS MGADVVFGSA QRFGVPMGFG GPHAAFFVAR DEHKRSMPGR
310 320 330 340 350
IIGVSKDTRG NRALRMAMQT REQHIRREKA NSNICTAQIL LANMASFYAV
360 370 380 390 400
FHGPQGLKTI ASRINRFADI LAAGLQAKGV SLVNNTWFDT ISIKGLDVAA
410 420 430 440 450
VNARALAAEM NLRFDADGIV GVSLDETTIR TDIDALFEVI LGAGHGLDVA
460 470 480 490 500
ALDAQIVAQG SQSIPASLVR EDAILSHPTF NRYQSETEMM RYIKRLESKD
510 520 530 540 550
LALNYSMISL GSCTMKLNAA VEMIPVSWPE FANMHPFCPL DQAKGYTQLI
560 570 580 590 600
EELSSWLVNV TGYDAVCIQP NSGAQGEYAG LLAIRKYHES RGEAHRNICL
610 620 630 640 650
IPQSAHGTNP ASAQLAGMQV VVTACDKQGN VDLEDLKAKA AEVAENLSCI
660 670 680 690 700
MITYPSTHGV YEETVREICN IVHQHGGQVY LDGANMNAQV GLTSPGFIGA
710 720 730 740 750
DVSHLNLHKT FAIPHGGGGP GMGPIGVKAH LAPFVAGHVV VKPGRESDNN
760 770 780 790 800
GAVSAAPYGS AGILPISWMY IKLLGSKGLK KSTQTALLNA NYVMKKLSEH
810 820 830 840 850
YPVLFRGRND RVAHECIIDL RPIKEASGVT EMDIAKRLND YGFHAPTMSF
860 870 880 890 900
PVAGTLMIEP TESESKVELD RFIDAMVSIR AEIAKVEAGE WPADNNPLHN
910 920 930 940 950
APHTMADIMD SAFDSRPYSR EVAVFPSAAV RTNKFWPTVN RIDDVYGDRN
960
LFCACVPLSD YE
Length:962
Mass (Da):104,673
Last modified:March 1, 2003 - v1
Checksum:iF5F66632ADD77412
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA Translation: AAN53857.1
RefSeqiNP_716412.1, NC_004347.2
WP_011071084.1, NC_004347.2

Genome annotation databases

EnsemblBacteriaiAAN53857; AAN53857; SO_0781
GeneIDi1168636
KEGGison:SO_0781
PATRICifig|211586.12.peg.751

Similar proteinsi

Entry informationi

Entry nameiGCSP_SHEON
AccessioniPrimary (citable) accession number: Q8EIQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health