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Q8EIQ6 (GCSP_SHEON) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:SO_0781
OrganismShewanella oneidensis (strain MR-1) [Reference proteome] [HAMAP]
Taxonomic identifier211586 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length962 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 962962Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166936

Amino acid modifications

Modified residue7091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8EIQ6 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: F5F66632ADD77412

FASTA962104,673
        10         20         30         40         50         60 
MTKQTLTQLE QHDLFLRRHI GPDSSQQQEM LNYVGAESLD DLTAQIVPES IRLSQELSIG 

        70         80         90        100        110        120 
DSCGEAEGIA YIRGLAKQNQ VFKSYIGMGY YGTQVPNVIL RNVLENPGWY TAYTPYQPEI 

       130        140        150        160        170        180 
AQGRLEAILN FQQVSMDLTG LDLASASLLD EATAAAEAMA LAKRVSKAKK ANIFFVADDV 

       190        200        210        220        230        240 
FPQTLDVVKT RAECFGFEVV VGPASEAVNH ELFGALFQYS NRFGQITDFT DLFAELRAKN 

       250        260        270        280        290        300 
VIVTVAADIM SLVLLKSPGS MGADVVFGSA QRFGVPMGFG GPHAAFFVAR DEHKRSMPGR 

       310        320        330        340        350        360 
IIGVSKDTRG NRALRMAMQT REQHIRREKA NSNICTAQIL LANMASFYAV FHGPQGLKTI 

       370        380        390        400        410        420 
ASRINRFADI LAAGLQAKGV SLVNNTWFDT ISIKGLDVAA VNARALAAEM NLRFDADGIV 

       430        440        450        460        470        480 
GVSLDETTIR TDIDALFEVI LGAGHGLDVA ALDAQIVAQG SQSIPASLVR EDAILSHPTF 

       490        500        510        520        530        540 
NRYQSETEMM RYIKRLESKD LALNYSMISL GSCTMKLNAA VEMIPVSWPE FANMHPFCPL 

       550        560        570        580        590        600 
DQAKGYTQLI EELSSWLVNV TGYDAVCIQP NSGAQGEYAG LLAIRKYHES RGEAHRNICL 

       610        620        630        640        650        660 
IPQSAHGTNP ASAQLAGMQV VVTACDKQGN VDLEDLKAKA AEVAENLSCI MITYPSTHGV 

       670        680        690        700        710        720 
YEETVREICN IVHQHGGQVY LDGANMNAQV GLTSPGFIGA DVSHLNLHKT FAIPHGGGGP 

       730        740        750        760        770        780 
GMGPIGVKAH LAPFVAGHVV VKPGRESDNN GAVSAAPYGS AGILPISWMY IKLLGSKGLK 

       790        800        810        820        830        840 
KSTQTALLNA NYVMKKLSEH YPVLFRGRND RVAHECIIDL RPIKEASGVT EMDIAKRLND 

       850        860        870        880        890        900 
YGFHAPTMSF PVAGTLMIEP TESESKVELD RFIDAMVSIR AEIAKVEAGE WPADNNPLHN 

       910        920        930        940        950        960 
APHTMADIMD SAFDSRPYSR EVAVFPSAAV RTNKFWPTVN RIDDVYGDRN LFCACVPLSD 


YE 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014299 Genomic DNA. Translation: AAN53857.1.
RefSeqNP_716412.1. NC_004347.2.

3D structure databases

ProteinModelPortalQ8EIQ6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING211586.SO_0781.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN53857; AAN53857; SO_0781.
GeneID1168636.
KEGGson:SO_0781.
PATRIC23521235. VBISheOne101494_0751.

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.
PhylomeDBQ8EIQ6.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_SHEON
AccessionPrimary (citable) accession number: Q8EIQ6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families