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Q8EIQ6

- GCSP_SHEON

UniProt

Q8EIQ6 - GCSP_SHEON

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, SO_0781
Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:SO_0781
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000166936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi211586.SO_0781.

Structurei

3D structure databases

ProteinModelPortaliQ8EIQ6.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.
PhylomeDBiQ8EIQ6.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8EIQ6-1 [UniParc]FASTAAdd to Basket

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MTKQTLTQLE QHDLFLRRHI GPDSSQQQEM LNYVGAESLD DLTAQIVPES    50
IRLSQELSIG DSCGEAEGIA YIRGLAKQNQ VFKSYIGMGY YGTQVPNVIL 100
RNVLENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD 150
EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVVKT RAECFGFEVV 200
VGPASEAVNH ELFGALFQYS NRFGQITDFT DLFAELRAKN VIVTVAADIM 250
SLVLLKSPGS MGADVVFGSA QRFGVPMGFG GPHAAFFVAR DEHKRSMPGR 300
IIGVSKDTRG NRALRMAMQT REQHIRREKA NSNICTAQIL LANMASFYAV 350
FHGPQGLKTI ASRINRFADI LAAGLQAKGV SLVNNTWFDT ISIKGLDVAA 400
VNARALAAEM NLRFDADGIV GVSLDETTIR TDIDALFEVI LGAGHGLDVA 450
ALDAQIVAQG SQSIPASLVR EDAILSHPTF NRYQSETEMM RYIKRLESKD 500
LALNYSMISL GSCTMKLNAA VEMIPVSWPE FANMHPFCPL DQAKGYTQLI 550
EELSSWLVNV TGYDAVCIQP NSGAQGEYAG LLAIRKYHES RGEAHRNICL 600
IPQSAHGTNP ASAQLAGMQV VVTACDKQGN VDLEDLKAKA AEVAENLSCI 650
MITYPSTHGV YEETVREICN IVHQHGGQVY LDGANMNAQV GLTSPGFIGA 700
DVSHLNLHKT FAIPHGGGGP GMGPIGVKAH LAPFVAGHVV VKPGRESDNN 750
GAVSAAPYGS AGILPISWMY IKLLGSKGLK KSTQTALLNA NYVMKKLSEH 800
YPVLFRGRND RVAHECIIDL RPIKEASGVT EMDIAKRLND YGFHAPTMSF 850
PVAGTLMIEP TESESKVELD RFIDAMVSIR AEIAKVEAGE WPADNNPLHN 900
APHTMADIMD SAFDSRPYSR EVAVFPSAAV RTNKFWPTVN RIDDVYGDRN 950
LFCACVPLSD YE 962
Length:962
Mass (Da):104,673
Last modified:March 1, 2003 - v1
Checksum:iF5F66632ADD77412
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN53857.1.
RefSeqiNP_716412.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN53857; AAN53857; SO_0781.
GeneIDi1168636.
KEGGison:SO_0781.
PATRICi23521235. VBISheOne101494_0751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN53857.1 .
RefSeqi NP_716412.1. NC_004347.2.

3D structure databases

ProteinModelPortali Q8EIQ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 211586.SO_0781.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN53857 ; AAN53857 ; SO_0781 .
GeneIDi 1168636.
KEGGi son:SO_0781.
PATRICi 23521235. VBISheOne101494_0751.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.
PhylomeDBi Q8EIQ6.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1.

Entry informationi

Entry nameiGCSP_SHEON
AccessioniPrimary (citable) accession number: Q8EIQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi