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Q8EI67

- RLMC_SHEON

UniProt

Q8EI67 - RLMC_SHEON

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Protein

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

Gene

rlmC

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi15 – 151Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi18 – 181Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi94 – 941Iron-sulfur (4Fe-4S)UniRule annotation
Binding sitei219 – 2191S-adenosyl-L-methionineUniRule annotation
Binding sitei248 – 2481S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei269 – 2691S-adenosyl-L-methionineUniRule annotation
Binding sitei316 – 3161S-adenosyl-L-methionineUniRule annotation
Active sitei343 – 3431NucleophileUniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. iron ion binding Source: UniProtKB-HAMAP
  3. RNA binding Source: InterPro
  4. rRNA (uridine-C5-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotation (EC:2.1.1.189UniRule annotation)
Alternative name(s):
23S rRNA(m5U747)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmCUniRule annotation
Synonyms:rumB
Ordered Locus Names:SO_0980
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 38638623S rRNA (uracil(747)-C(5))-methyltransferase RlmCPRO_0000161936Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_0980.

Structurei

3D structure databases

ProteinModelPortaliQ8EI67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2265.
HOGENOMiHOG000218547.
KOiK03212.
OMAiNIQPIHM.
OrthoDBiEOG6V4GKM.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01012. 23SrRNA_methyltr_RlmC.
InterProiIPR001566. 23S_rRNA_MeTrfase_RlmD.
IPR011825. 23SrRNA_MeTrfase_RlmC.
IPR029063. SAM-dependent_MTases-like.
IPR010280. U5_MeTrfase_fam.
[Graphical view]
PfamiPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02085. meth_trns_rumB. 1 hit.
TIGR00479. rumA. 1 hit.
PROSITEiPS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8EI67-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTLVQCGYF ERGQCQSCRH IKLPMVQQLA AKTQELQQLL APFVVSTNTQ
60 70 80 90 100
FLPPVVGEDS GFRNKAKMVV LGAAHAPVLG IVSPNGEAVS LCDCLLYPAD
110 120 130 140 150
MQALLYRLER FVQQAGIPPY RIDKAKGELK YILLTRSQVR GEYMLRFVLR
160 170 180 190 200
SPDAIARIER ELPALMAEYP QINVVSVNIQ PIHMAILEGD EEIFLTENTR
210 220 230 240 250
LEERFNDVPL FIRPKSFFQT NPHVAAKLYQ TAREWVGEFA PKSLWDLFCG
260 270 280 290 300
VGGFGLHCAS KDIPLTGIEI EAEAIACAKM SAQMMGLDNV QFMALDSTDF
310 320 330 340 350
AKGDAAATKP DLIIVNPPRR GIGESLCDAL SEFAPRAILY SSCNPKTLAK
360 370 380
DLVHIRGYQL TRVQLFDLFP HSDHFEVLAM LVKDSR
Length:386
Mass (Da):43,033
Last modified:April 3, 2007 - v2
Checksum:iC4B5C92D7421C64C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN54054.2.
RefSeqiNP_716609.2. NC_004347.2.
WP_011071254.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN54054; AAN54054; SO_0980.
GeneIDi1168823.
KEGGison:SO_0980.
PATRICi23521611. VBISheOne101494_0939.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN54054.2 .
RefSeqi NP_716609.2. NC_004347.2.
WP_011071254.1. NC_004347.2.

3D structure databases

ProteinModelPortali Q8EI67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 211586.SO_0980.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN54054 ; AAN54054 ; SO_0980 .
GeneIDi 1168823.
KEGGi son:SO_0980.
PATRICi 23521611. VBISheOne101494_0939.

Phylogenomic databases

eggNOGi COG2265.
HOGENOMi HOG000218547.
KOi K03212.
OMAi NIQPIHM.
OrthoDBi EOG6V4GKM.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01012. 23SrRNA_methyltr_RlmC.
InterProi IPR001566. 23S_rRNA_MeTrfase_RlmD.
IPR011825. 23SrRNA_MeTrfase_RlmC.
IPR029063. SAM-dependent_MTases-like.
IPR010280. U5_MeTrfase_fam.
[Graphical view ]
Pfami PF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR02085. meth_trns_rumB. 1 hit.
TIGR00479. rumA. 1 hit.
PROSITEi PS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1.

Entry informationi

Entry nameiRLMC_SHEON
AccessioniPrimary (citable) accession number: Q8EI67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: April 3, 2007
Last modified: October 1, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3