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Q8EI67 (RLMC_SHEON) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

EC=2.1.1.189
Alternative name(s):
23S rRNA(m5U747)-methyltransferase
Gene names
Name:rlmC
Synonyms:rumB
Ordered Locus Names:SO_0980
OrganismShewanella oneidensis (strain MR-1) [Reference proteome] [HAMAP]
Taxonomic identifier211586 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA By similarity. HAMAP-Rule MF_01012

Catalytic activity

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA. HAMAP-Rule MF_01012

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 38638623S rRNA (uracil(747)-C(5))-methyltransferase RlmC HAMAP-Rule MF_01012
PRO_0000161936

Sites

Active site3431Nucleophile By similarity
Metal binding71Iron-sulfur (4Fe-4S) By similarity
Metal binding151Iron-sulfur (4Fe-4S) By similarity
Metal binding181Iron-sulfur (4Fe-4S) By similarity
Metal binding941Iron-sulfur (4Fe-4S) By similarity
Binding site2191S-adenosyl-L-methionine By similarity
Binding site2481S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site2691S-adenosyl-L-methionine By similarity
Binding site3161S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8EI67 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: C4B5C92D7421C64C

FASTA38643,033
        10         20         30         40         50         60 
MSTLVQCGYF ERGQCQSCRH IKLPMVQQLA AKTQELQQLL APFVVSTNTQ FLPPVVGEDS 

        70         80         90        100        110        120 
GFRNKAKMVV LGAAHAPVLG IVSPNGEAVS LCDCLLYPAD MQALLYRLER FVQQAGIPPY 

       130        140        150        160        170        180 
RIDKAKGELK YILLTRSQVR GEYMLRFVLR SPDAIARIER ELPALMAEYP QINVVSVNIQ 

       190        200        210        220        230        240 
PIHMAILEGD EEIFLTENTR LEERFNDVPL FIRPKSFFQT NPHVAAKLYQ TAREWVGEFA 

       250        260        270        280        290        300 
PKSLWDLFCG VGGFGLHCAS KDIPLTGIEI EAEAIACAKM SAQMMGLDNV QFMALDSTDF 

       310        320        330        340        350        360 
AKGDAAATKP DLIIVNPPRR GIGESLCDAL SEFAPRAILY SSCNPKTLAK DLVHIRGYQL 

       370        380 
TRVQLFDLFP HSDHFEVLAM LVKDSR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014299 Genomic DNA. Translation: AAN54054.2.
RefSeqNP_716609.2. NC_004347.2.

3D structure databases

ProteinModelPortalQ8EI67.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING211586.SO_0980.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN54054; AAN54054; SO_0980.
GeneID1168823.
KEGGson:SO_0980.
PATRIC23521611. VBISheOne101494_0939.

Phylogenomic databases

eggNOGCOG2265.
HOGENOMHOG000218547.
KOK03212.
OMANIQPIHM.
OrthoDBEOG6V4GKM.
ProtClustDBPRK03522.

Family and domain databases

HAMAPMF_01012. 23SrRNA_methyltr_RlmC.
InterProIPR001566. 23S_rRNA_MeTrfase_RlmD.
IPR011825. 23SrRNA_MeTrfase_RlmC.
IPR010280. U5_MeTrfase_fam.
[Graphical view]
PfamPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
TIGRFAMsTIGR02085. meth_trns_rumB. 1 hit.
TIGR00479. rumA. 1 hit.
PROSITEPS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRLMC_SHEON
AccessionPrimary (citable) accession number: Q8EI67
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: April 3, 2007
Last modified: February 19, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families