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Q8EI67

- RLMC_SHEON

UniProt

Q8EI67 - RLMC_SHEON

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Protein
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC
Gene
rlmC, rumB, SO_0980
Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71Iron-sulfur (4Fe-4S) By similarity
Metal bindingi15 – 151Iron-sulfur (4Fe-4S) By similarity
Metal bindingi18 – 181Iron-sulfur (4Fe-4S) By similarity
Metal bindingi94 – 941Iron-sulfur (4Fe-4S) By similarity
Binding sitei219 – 2191S-adenosyl-L-methionine By similarity
Binding sitei248 – 2481S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei269 – 2691S-adenosyl-L-methionine By similarity
Binding sitei316 – 3161S-adenosyl-L-methionine By similarity
Active sitei343 – 3431Nucleophile By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. iron ion binding Source: UniProtKB-HAMAP
  4. rRNA (uridine-C5-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC (EC:2.1.1.189)
Alternative name(s):
23S rRNA(m5U747)-methyltransferase
Gene namesi
Name:rlmC
Synonyms:rumB
Ordered Locus Names:SO_0980
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 38638623S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotation
PRO_0000161936Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_0980.

Structurei

3D structure databases

ProteinModelPortaliQ8EI67.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2265.
HOGENOMiHOG000218547.
KOiK03212.
OMAiNIQPIHM.
OrthoDBiEOG6V4GKM.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01012. 23SrRNA_methyltr_RlmC.
InterProiIPR001566. 23S_rRNA_MeTrfase_RlmD.
IPR011825. 23SrRNA_MeTrfase_RlmC.
IPR029063. SAM-dependent_MTases-like.
IPR010280. U5_MeTrfase_fam.
[Graphical view]
PfamiPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02085. meth_trns_rumB. 1 hit.
TIGR00479. rumA. 1 hit.
PROSITEiPS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8EI67-1 [UniParc]FASTAAdd to Basket

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MSTLVQCGYF ERGQCQSCRH IKLPMVQQLA AKTQELQQLL APFVVSTNTQ    50
FLPPVVGEDS GFRNKAKMVV LGAAHAPVLG IVSPNGEAVS LCDCLLYPAD 100
MQALLYRLER FVQQAGIPPY RIDKAKGELK YILLTRSQVR GEYMLRFVLR 150
SPDAIARIER ELPALMAEYP QINVVSVNIQ PIHMAILEGD EEIFLTENTR 200
LEERFNDVPL FIRPKSFFQT NPHVAAKLYQ TAREWVGEFA PKSLWDLFCG 250
VGGFGLHCAS KDIPLTGIEI EAEAIACAKM SAQMMGLDNV QFMALDSTDF 300
AKGDAAATKP DLIIVNPPRR GIGESLCDAL SEFAPRAILY SSCNPKTLAK 350
DLVHIRGYQL TRVQLFDLFP HSDHFEVLAM LVKDSR 386
Length:386
Mass (Da):43,033
Last modified:April 3, 2007 - v2
Checksum:iC4B5C92D7421C64C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN54054.2.
RefSeqiNP_716609.2. NC_004347.2.
WP_011071254.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN54054; AAN54054; SO_0980.
GeneIDi1168823.
KEGGison:SO_0980.
PATRICi23521611. VBISheOne101494_0939.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN54054.2 .
RefSeqi NP_716609.2. NC_004347.2.
WP_011071254.1. NC_004347.2.

3D structure databases

ProteinModelPortali Q8EI67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 211586.SO_0980.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN54054 ; AAN54054 ; SO_0980 .
GeneIDi 1168823.
KEGGi son:SO_0980.
PATRICi 23521611. VBISheOne101494_0939.

Phylogenomic databases

eggNOGi COG2265.
HOGENOMi HOG000218547.
KOi K03212.
OMAi NIQPIHM.
OrthoDBi EOG6V4GKM.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01012. 23SrRNA_methyltr_RlmC.
InterProi IPR001566. 23S_rRNA_MeTrfase_RlmD.
IPR011825. 23SrRNA_MeTrfase_RlmC.
IPR029063. SAM-dependent_MTases-like.
IPR010280. U5_MeTrfase_fam.
[Graphical view ]
Pfami PF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR02085. meth_trns_rumB. 1 hit.
TIGR00479. rumA. 1 hit.
PROSITEi PS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1.

Entry informationi

Entry nameiRLMC_SHEON
AccessioniPrimary (citable) accession number: Q8EI67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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