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Q8EI67

- RLMC_SHEON

UniProt

Q8EI67 - RLMC_SHEON

Protein

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

Gene

rlmC

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi7 – 71Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi15 – 151Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi18 – 181Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi94 – 941Iron-sulfur (4Fe-4S)UniRule annotation
    Binding sitei219 – 2191S-adenosyl-L-methionineUniRule annotation
    Binding sitei248 – 2481S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei269 – 2691S-adenosyl-L-methionineUniRule annotation
    Binding sitei316 – 3161S-adenosyl-L-methionineUniRule annotation
    Active sitei343 – 3431NucleophileUniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. iron ion binding Source: UniProtKB-HAMAP
    3. RNA binding Source: InterPro
    4. rRNA (uridine-C5-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    23S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotation (EC:2.1.1.189UniRule annotation)
    Alternative name(s):
    23S rRNA(m5U747)-methyltransferaseUniRule annotation
    Gene namesi
    Name:rlmCUniRule annotation
    Synonyms:rumB
    Ordered Locus Names:SO_0980
    OrganismiShewanella oneidensis (strain MR-1)
    Taxonomic identifieri211586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000008186: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 38638623S rRNA (uracil(747)-C(5))-methyltransferase RlmCPRO_0000161936Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi211586.SO_0980.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8EI67.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2265.
    HOGENOMiHOG000218547.
    KOiK03212.
    OMAiNIQPIHM.
    OrthoDBiEOG6V4GKM.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01012. 23SrRNA_methyltr_RlmC.
    InterProiIPR001566. 23S_rRNA_MeTrfase_RlmD.
    IPR011825. 23SrRNA_MeTrfase_RlmC.
    IPR029063. SAM-dependent_MTases-like.
    IPR010280. U5_MeTrfase_fam.
    [Graphical view]
    PfamiPF05958. tRNA_U5-meth_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR02085. meth_trns_rumB. 1 hit.
    TIGR00479. rumA. 1 hit.
    PROSITEiPS51687. SAM_MT_RNA_M5U. 1 hit.
    PS01230. TRMA_1. 1 hit.
    PS01231. TRMA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8EI67-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTLVQCGYF ERGQCQSCRH IKLPMVQQLA AKTQELQQLL APFVVSTNTQ    50
    FLPPVVGEDS GFRNKAKMVV LGAAHAPVLG IVSPNGEAVS LCDCLLYPAD 100
    MQALLYRLER FVQQAGIPPY RIDKAKGELK YILLTRSQVR GEYMLRFVLR 150
    SPDAIARIER ELPALMAEYP QINVVSVNIQ PIHMAILEGD EEIFLTENTR 200
    LEERFNDVPL FIRPKSFFQT NPHVAAKLYQ TAREWVGEFA PKSLWDLFCG 250
    VGGFGLHCAS KDIPLTGIEI EAEAIACAKM SAQMMGLDNV QFMALDSTDF 300
    AKGDAAATKP DLIIVNPPRR GIGESLCDAL SEFAPRAILY SSCNPKTLAK 350
    DLVHIRGYQL TRVQLFDLFP HSDHFEVLAM LVKDSR 386
    Length:386
    Mass (Da):43,033
    Last modified:April 3, 2007 - v2
    Checksum:iC4B5C92D7421C64C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN54054.2.
    RefSeqiNP_716609.2. NC_004347.2.
    WP_011071254.1. NC_004347.2.

    Genome annotation databases

    EnsemblBacteriaiAAN54054; AAN54054; SO_0980.
    GeneIDi1168823.
    KEGGison:SO_0980.
    PATRICi23521611. VBISheOne101494_0939.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN54054.2 .
    RefSeqi NP_716609.2. NC_004347.2.
    WP_011071254.1. NC_004347.2.

    3D structure databases

    ProteinModelPortali Q8EI67.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 211586.SO_0980.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN54054 ; AAN54054 ; SO_0980 .
    GeneIDi 1168823.
    KEGGi son:SO_0980.
    PATRICi 23521611. VBISheOne101494_0939.

    Phylogenomic databases

    eggNOGi COG2265.
    HOGENOMi HOG000218547.
    KOi K03212.
    OMAi NIQPIHM.
    OrthoDBi EOG6V4GKM.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01012. 23SrRNA_methyltr_RlmC.
    InterProi IPR001566. 23S_rRNA_MeTrfase_RlmD.
    IPR011825. 23SrRNA_MeTrfase_RlmC.
    IPR029063. SAM-dependent_MTases-like.
    IPR010280. U5_MeTrfase_fam.
    [Graphical view ]
    Pfami PF05958. tRNA_U5-meth_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR02085. meth_trns_rumB. 1 hit.
    TIGR00479. rumA. 1 hit.
    PROSITEi PS51687. SAM_MT_RNA_M5U. 1 hit.
    PS01230. TRMA_1. 1 hit.
    PS01231. TRMA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MR-1.

    Entry informationi

    Entry nameiRLMC_SHEON
    AccessioniPrimary (citable) accession number: Q8EI67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3