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Protein

Peptide deformylase 2

Gene

def2

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109IronUniRule annotation1
Metal bindingi151IronUniRule annotation1
Active sitei152UniRule annotation1
Metal bindingi155IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciSONE211586:G1GMP-981-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 2UniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDF 2UniRule annotation
Alternative name(s):
Polypeptide deformylase 2UniRule annotation
Gene namesi
Name:def2UniRule annotation
Ordered Locus Names:SO_1062
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000828351 – 181Peptide deformylase 2Add BLAST181

Proteomic databases

PaxDbiQ8EHZ2

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_1062

Structurei

3D structure databases

ProteinModelPortaliQ8EHZ2
SMRiQ8EHZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108RBJ Bacteria
COG0242 LUCA
HOGENOMiHOG000243508
KOiK01462
OMAiDGFHARV
OrthoDBiPOG091H02B0
PhylomeDBiQ8EHZ2

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

Q8EHZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKDEMRQTP NKPLPIAVVG EAILKQQAIE VRDFDDTLSQ LASQMAASMV
60 70 80 90 100
EAKGVGIAAP QVHSPLALFI MASRPNERYP DAPLMEPLVV VNPQIVLRSL
110 120 130 140 150
QLEKGEEGCL SVPGQRFTIW RPQTIVVRYQ NLAGQWQHSE LTGFIARIFQ
160 170 180
HEFDHLQGIT LLERSQMPEQ KLMAQEGKPQ A
Length:181
Mass (Da):20,325
Last modified:March 1, 2003 - v1
Checksum:iBF5C27BADEA587C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA Translation: AAN54134.1
RefSeqiNP_716689.1, NC_004347.2
WP_011071316.1, NC_004347.2

Genome annotation databases

EnsemblBacteriaiAAN54134; AAN54134; SO_1062
GeneIDi1168899
KEGGison:SO_1062
PATRICifig|211586.12.peg.1019

Similar proteinsi

Entry informationi

Entry nameiDEF2_SHEON
AccessioniPrimary (citable) accession number: Q8EHZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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