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Q8EHU2

- PROB_SHEON

UniProt

Q8EHU2 - PROB_SHEON

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Protein
Glutamate 5-kinase
Gene
proB, SO_1121
Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141ATP By similarity
Binding sitei54 – 541Substrate By similarity
Binding sitei141 – 1411Substrate By similarity
Binding sitei153 – 1531Substrate; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi173 – 1742ATP By similarity
Nucleotide bindingi215 – 2217ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. glutamate 5-kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00098; UER00359.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinase (EC:2.7.2.11)
Alternative name(s):
Gamma-glutamyl kinase
Short name:
GK
Gene namesi
Name:proB
Ordered Locus Names:SO_1121
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Glutamate 5-kinaseUniRule annotation
PRO_0000109724Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_1121.

Structurei

3D structure databases

ProteinModelPortaliQ8EHU2.
SMRiQ8EHU2. Positions 11-370.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini280 – 35879PUA
Add
BLAST

Sequence similaritiesi

Contains 1 PUA domain.

Phylogenomic databases

eggNOGiCOG0263.
HOGENOMiHOG000246368.
KOiK00931.
OMAiMRMIAGH.
OrthoDBiEOG6PGK7G.
PhylomeDBiQ8EHU2.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
3.40.1160.10. 1 hit.
HAMAPiMF_00456. ProB.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view]
PIRSFiPIRSF000729. GK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF53633. SSF53633. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR01027. proB. 1 hit.
PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
PS50890. PUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8EHU2-1 [UniParc]FASTAAdd to Basket

« Hide

MNLSEIAYRR VVVKLGTSVL TSGSKQLDKA HMVELARQMA ALMRSGVEVV    50
LCTSGAIAAG REHLQYPALP DTMANKQLLA AVGQSQLILA WAQLFSIYGL 100
HVGQLLLTRA DLHDRERYLN ARDTLNALLA NNIIPIINEN DAVATNEIKV 150
GDNDNLSARA ALLCDADLLI LLTDQKGLFD ADPRTNPNAK LISQVEKIDD 200
SLRLLAGGSV SGLGTGGMST KLEAADIARR AGIEVVIASG HHPDVIKKVV 250
AKESIGTHFS AIENPLESRK QWILAGPAAQ GSLVLDAGAV KAVTEKGRSL 300
LSKGIIGVKG EFERGATLQL VDQNGKIIAR GITRYCGEAL GLIAGKHSDE 350
IESVLGYDYG DAIVHRNDMV VL 372
Length:372
Mass (Da):39,673
Last modified:March 1, 2003 - v1
Checksum:iE0149877E7848345
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN54191.1.
RefSeqiNP_716746.1. NC_004347.2.
WP_011071362.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN54191; AAN54191; SO_1121.
GeneIDi1168953.
KEGGison:SO_1121.
PATRICi23521882. VBISheOne101494_1074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN54191.1 .
RefSeqi NP_716746.1. NC_004347.2.
WP_011071362.1. NC_004347.2.

3D structure databases

ProteinModelPortali Q8EHU2.
SMRi Q8EHU2. Positions 11-370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 211586.SO_1121.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN54191 ; AAN54191 ; SO_1121 .
GeneIDi 1168953.
KEGGi son:SO_1121.
PATRICi 23521882. VBISheOne101494_1074.

Phylogenomic databases

eggNOGi COG0263.
HOGENOMi HOG000246368.
KOi K00931.
OMAi MRMIAGH.
OrthoDBi EOG6PGK7G.
PhylomeDBi Q8EHU2.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00359 .

Family and domain databases

Gene3Di 2.30.130.10. 1 hit.
3.40.1160.10. 1 hit.
HAMAPi MF_00456. ProB.
InterProi IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view ]
PIRSFi PIRSF000729. GK. 1 hit.
PRINTSi PR00474. GLU5KINASE.
SMARTi SM00359. PUA. 1 hit.
[Graphical view ]
SUPFAMi SSF53633. SSF53633. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsi TIGR01027. proB. 1 hit.
PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
PS50890. PUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1.

Entry informationi

Entry nameiPROB_SHEON
AccessioniPrimary (citable) accession number: Q8EHU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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