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Q8EHP4

- SYL_SHEON

UniProt

Q8EHP4 - SYL_SHEON

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:SO_1174
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Leucine--tRNA ligasePRO_0000152079Add
BLAST

Proteomic databases

PRIDEiQ8EHP4.

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_1174.

Structurei

3D structure databases

ProteinModelPortaliQ8EHP4.
SMRiQ8EHP4. Positions 228-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi618 – 6225"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.
PhylomeDBiQ8EHP4.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8EHP4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEQYNPSEI EALVQKHWHD TKTFEVTEDQ NKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVARFQRLQG KNVLQPIGWD SFGLPAENAA INNKTAPAPW
110 120 130 140 150
TYQNIEYMKN QLKLLGFGYD WSREIATCTP EYYRWEQWFF TKLYEKGLVY
160 170 180 190 200
KKTASVNWCP NDETVLANEQ VQDGCCWRCD TPVEQKEIPQ WFIKITAYAE
210 220 230 240 250
ELLNDIDTLD GWPEQVKTMQ RNWIGRSEGV EMTFGVAGSD KSFDIYTTRP
260 270 280 290 300
DTLMGVTYVA IAAGHPLAEI AAQTNPELAA FIDECKNSTT SEAELATMEK
310 320 330 340 350
RGVATGLYAI HPITGKQVPI WAANFVLMNY GTGAVMSVPG HDQRDYEFAK
360 370 380 390 400
KYHLPIEAVI KPAEGDLDIS EAAYTEKGIL FNSGEFDGLD FDGAFNVIAN
410 420 430 440 450
KLVAEGKGKR QVNYRLRDWG VSRQRYWGAP IPMVTLADGT VIPTPEDQLP
460 470 480 490 500
VILPEDVVMD GIQSPIKADK EWAKTQVNGQ DALRETDTFD TFMESSWYYA
510 520 530 540 550
RYCSPQAEQM LDPTKANYWL PVDQYIGGIE HACMHLLYFR FFHKLLRDAG
560 570 580 590 600
LVNTNEPAKQ LLTQGMVLAD AFYYTNDKGA RVWVSPLDVA TTEKDDKGRI
610 620 630 640 650
TKAIDKDGNE LVYTGMCKMS KSKNNGIDPQ VMVEKYGADT VRLFMMFASP
660 670 680 690 700
PELTLEWQES GVEGAHRFIK RLWKLASEYV AQDNSEALDV SKLTSEQKAL
710 720 730 740 750
RREVHKTIAK VTDDIGRRQM FNTAVAAVME LMNHLQKAPQ TTGQDRAIIG
760 770 780 790 800
EALSAVVRLL YPIIPHVSFT LWNELGNTNS IEDSQWPVVD ESALVEDSKL
810 820 830 840 850
IVVQVNGKVR AKITVAADAD QASVEALGMA DEQVIKYLDG VTVRKVIYVP

GKLLSIVAN
Length:859
Mass (Da):96,827
Last modified:March 1, 2003 - v1
Checksum:iC78D6209DFB6CA17
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN54244.1.
RefSeqiNP_716799.1. NC_004347.2.
WP_011071405.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN54244; AAN54244; SO_1174.
GeneIDi1169003.
KEGGison:SO_1174.
PATRICi23521988. VBISheOne101494_1126.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN54244.1 .
RefSeqi NP_716799.1. NC_004347.2.
WP_011071405.1. NC_004347.2.

3D structure databases

ProteinModelPortali Q8EHP4.
SMRi Q8EHP4. Positions 228-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 211586.SO_1174.

Proteomic databases

PRIDEi Q8EHP4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN54244 ; AAN54244 ; SO_1174 .
GeneIDi 1169003.
KEGGi son:SO_1174.
PATRICi 23521988. VBISheOne101494_1126.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.
PhylomeDBi Q8EHP4.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1.

Entry informationi

Entry nameiSYL_SHEON
AccessioniPrimary (citable) accession number: Q8EHP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3