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Q8EHP4

- SYL_SHEON

UniProt

Q8EHP4 - SYL_SHEON

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei621 – 6211ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:SO_1174
    OrganismiShewanella oneidensis (strain MR-1)
    Taxonomic identifieri211586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000008186: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 859859Leucine--tRNA ligasePRO_0000152079Add
    BLAST

    Proteomic databases

    PRIDEiQ8EHP4.

    Interactioni

    Protein-protein interaction databases

    STRINGi211586.SO_1174.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8EHP4.
    SMRiQ8EHP4. Positions 228-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi618 – 6225"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.
    PhylomeDBiQ8EHP4.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8EHP4-1 [UniParc]FASTAAdd to Basket

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    MQEQYNPSEI EALVQKHWHD TKTFEVTEDQ NKEKFYCLSM FPYPSGRLHM    50
    GHVRNYTIGD VVARFQRLQG KNVLQPIGWD SFGLPAENAA INNKTAPAPW 100
    TYQNIEYMKN QLKLLGFGYD WSREIATCTP EYYRWEQWFF TKLYEKGLVY 150
    KKTASVNWCP NDETVLANEQ VQDGCCWRCD TPVEQKEIPQ WFIKITAYAE 200
    ELLNDIDTLD GWPEQVKTMQ RNWIGRSEGV EMTFGVAGSD KSFDIYTTRP 250
    DTLMGVTYVA IAAGHPLAEI AAQTNPELAA FIDECKNSTT SEAELATMEK 300
    RGVATGLYAI HPITGKQVPI WAANFVLMNY GTGAVMSVPG HDQRDYEFAK 350
    KYHLPIEAVI KPAEGDLDIS EAAYTEKGIL FNSGEFDGLD FDGAFNVIAN 400
    KLVAEGKGKR QVNYRLRDWG VSRQRYWGAP IPMVTLADGT VIPTPEDQLP 450
    VILPEDVVMD GIQSPIKADK EWAKTQVNGQ DALRETDTFD TFMESSWYYA 500
    RYCSPQAEQM LDPTKANYWL PVDQYIGGIE HACMHLLYFR FFHKLLRDAG 550
    LVNTNEPAKQ LLTQGMVLAD AFYYTNDKGA RVWVSPLDVA TTEKDDKGRI 600
    TKAIDKDGNE LVYTGMCKMS KSKNNGIDPQ VMVEKYGADT VRLFMMFASP 650
    PELTLEWQES GVEGAHRFIK RLWKLASEYV AQDNSEALDV SKLTSEQKAL 700
    RREVHKTIAK VTDDIGRRQM FNTAVAAVME LMNHLQKAPQ TTGQDRAIIG 750
    EALSAVVRLL YPIIPHVSFT LWNELGNTNS IEDSQWPVVD ESALVEDSKL 800
    IVVQVNGKVR AKITVAADAD QASVEALGMA DEQVIKYLDG VTVRKVIYVP 850
    GKLLSIVAN 859
    Length:859
    Mass (Da):96,827
    Last modified:March 1, 2003 - v1
    Checksum:iC78D6209DFB6CA17
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN54244.1.
    RefSeqiNP_716799.1. NC_004347.2.

    Genome annotation databases

    EnsemblBacteriaiAAN54244; AAN54244; SO_1174.
    GeneIDi1169003.
    KEGGison:SO_1174.
    PATRICi23521988. VBISheOne101494_1126.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN54244.1 .
    RefSeqi NP_716799.1. NC_004347.2.

    3D structure databases

    ProteinModelPortali Q8EHP4.
    SMRi Q8EHP4. Positions 228-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 211586.SO_1174.

    Proteomic databases

    PRIDEi Q8EHP4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN54244 ; AAN54244 ; SO_1174 .
    GeneIDi 1169003.
    KEGGi son:SO_1174.
    PATRICi 23521988. VBISheOne101494_1126.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.
    PhylomeDBi Q8EHP4.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MR-1.

    Entry informationi

    Entry nameiSYL_SHEON
    AccessioniPrimary (citable) accession number: Q8EHP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3