Q8EHK4 (DEOC_SHEON) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	SO_1217

Organism

Shewanella oneidensis

Taxonomic identifier

70863 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00592
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00592
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00592
Subcellular location	Cytoplasm By similarity HAMAP MF_00592.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Deoxyribose-phosphate aldolase HAMAP MF_00592		PRO_0000057303
Sites
	Active site	165	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	197	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8EHK4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 65BFE12A9E1A30C4	FASTA	256	27,445
	10 20 30 40 50 60 MTDLKKAAQR AIELMDLTTL NDDDTDQKVI DLCHKAVTPA GNTAAICIYP RFIPIARKTL 70 80 90 100 110 120 DELGAEDIQI ATVTNFPHGN DDIAIAVLET RAAVAYGADE VDVVFPYRAL MEGNETVGYE 130 140 150 160 170 180 LVKACKEACG EVLLKVIIES GVLADPVLIR RASELSIEAG ADFIKTSTGK VPVNATLEAA 190 200 210 220 230 240 EIMLTVISEK NTKVGFKPAG GVRDAAQAAE FLGVAERILG ADWVSPRTFR FGASSLLNSL 250 LHTLELADAP KRTQGY

References

[1]

"Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis." Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C., Read T.D., Eisen J.A., Seshadri R., Ward N.L., Methe B.A., Clayton R.A., Meyer T., Tsapin A., Scott J., Beanan M.J., Brinkac L.M., Daugherty S.C., DeBoy R.T. , Dodson R.J., Durkin A.S., Haft D.H., Kolonay J.F., Madupu R., Peterson J.D., Umayam L.A., White O., Wolf A.M., Vamathevan J.J., Weidman J.F., Impraim M., Lee K., Berry K.J., Lee C., Mueller J., Khouri H.M., Gill J., Utterback T.R., McDonald L.A., Feldblyum T.V., Smith H.O., Venter J.C., Nealson K.H., Fraser C.M. Nat. Biotechnol. 20:1118-1123(2002) [PubMed: 12368813] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MR-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014299 Genomic DNA. Translation: AAN54285.1.
RefSeq	NP_716840.1. NC_004347.1.
3D structure databases
ProteinModelPortal	Q8EHK4.
SMR	Q8EHK4. Positions 1-232.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1169044.
GenomeReviews	Gene locus SO_1217 in contig AE014299_GR.
KEGG	son:SO_1217.
NMPDR	fig|211586.1.peg.1129.
PATRIC	23522092. VBISheOne101494_1169.
TIGR	SO_1217.
Phylogenomic databases
HOGENOM	HBG636421.
OMA	FELVKQC.
ProtClustDB	PRK05283.
Enzyme and pathway databases
BioCyc	SONE211586:SO_1217-MONOMER.
Family and domain databases
HAMAP	MF_00592. DeoC_type2. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR023649. DeoC_bac. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_SHEON

Accession

Primary (citable) accession number: Q8EHK4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program