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Q8EHD3

- UPPP1_SHEON

UniProt

Q8EHD3 - UPPP1_SHEON

Protein

Undecaprenyl-diphosphatase 1

Gene

uppP1

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphatase 1UniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance protein 1UniRule annotation
    Undecaprenyl pyrophosphate phosphatase 1UniRule annotation
    Gene namesi
    Name:uppP1UniRule annotation
    Synonyms:bacA1, upk1
    Ordered Locus Names:SO_1293
    OrganismiShewanella oneidensis (strain MR-1)
    Taxonomic identifieri211586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000008186: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Undecaprenyl-diphosphatase 1PRO_0000151194Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi211586.SO_1293.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei39 – 5921HelicalUniRule annotationAdd
    BLAST
    Transmembranei87 – 10721HelicalUniRule annotationAdd
    BLAST
    Transmembranei114 – 13421HelicalUniRule annotationAdd
    BLAST
    Transmembranei149 – 16921HelicalUniRule annotationAdd
    BLAST
    Transmembranei183 – 20321HelicalUniRule annotationAdd
    BLAST
    Transmembranei218 – 23821HelicalUniRule annotationAdd
    BLAST
    Transmembranei246 – 26621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiISTHRFT.
    OrthoDBiEOG6QP13M.
    PhylomeDBiQ8EHD3.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8EHD3-1 [UniParc]FASTAAdd to Basket

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    MDTFQVIILA LIQGLTEFLP ISSSAHLILP AQLLGWEDQG LSFDVAVNTG    50
    SLFAVVIYFR HELWAMFKAW IASIVKGQHS DDSKLAWWII LATLPAVFFG 100
    FMAKDFIATH LRNTGVIAVT TVVFGLLLWW ADKMSRHDLT IYQTGWRKAL 150
    LIGFAQALAL IPGTSRSGAT MTAALMLGLS RDAAARFSFL MSVPVSLGAA 200
    ILVGKDLAES PLPIDYQALT LGTVISFAAA YLCIHYFLKI ISRMGMTPFV 250
    IYRLALGAVL CGFIFL 266
    Length:266
    Mass (Da):29,124
    Last modified:March 1, 2003 - v1
    Checksum:iF857D147C3471D61
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN54360.1.
    RefSeqiNP_716915.1. NC_004347.2.
    WP_011071506.1. NC_004347.2.

    Genome annotation databases

    EnsemblBacteriaiAAN54360; AAN54360; SO_1293.
    GeneIDi1169112.
    KEGGison:SO_1293.
    PATRICi23522234. VBISheOne101494_1239.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN54360.1 .
    RefSeqi NP_716915.1. NC_004347.2.
    WP_011071506.1. NC_004347.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 211586.SO_1293.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN54360 ; AAN54360 ; SO_1293 .
    GeneIDi 1169112.
    KEGGi son:SO_1293.
    PATRICi 23522234. VBISheOne101494_1239.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi ISTHRFT.
    OrthoDBi EOG6QP13M.
    PhylomeDBi Q8EHD3.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MR-1.

    Entry informationi

    Entry nameiUPPP1_SHEON
    AccessioniPrimary (citable) accession number: Q8EHD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3