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Q8EH68

- TYRA_SHEON

UniProt

Q8EH68 - TYRA_SHEON

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Protein

T-protein

Gene

tyrA

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Chorismate = prephenate.
Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi

GO - Molecular functioni

  1. chorismate mutase activity Source: UniProtKB-EC
  2. prephenate dehydrogenase (NADP+) activity Source: InterPro
  3. prephenate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. chorismate metabolic process Source: InterPro
  2. tyrosine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00120; UER00203.
UPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
T-protein
Including the following 2 domains:
Chorismate mutase (EC:5.4.99.5)
Short name:
CM
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:SO_1362
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379T-proteinPRO_0000398177Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_1362.

Structurei

3D structure databases

ProteinModelPortaliQ8EH68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 9492Chorismate mutasePROSITE-ProRule annotationAdd
BLAST
Domaini103 – 366264Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 chorismate mutase domain.PROSITE-ProRule annotation
Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0287.
HOGENOMiHOG000275725.
KOiK14187.
OMAiQANDSRQ.
OrthoDBiEOG618R0Z.
PhylomeDBiQ8EH68.

Family and domain databases

Gene3Di1.20.59.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR008244. Chor_mut/prephenate_DH_T.
IPR002701. Chorismate_mutase.
IPR020822. Chorismate_mutase_type_II.
IPR011277. CM_T.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF01817. CM_2. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
PIRSFiPIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
SMARTiSM00830. CM_2. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF48600. SSF48600. 1 hit.
TIGRFAMsiTIGR01799. CM_T. 1 hit.
PROSITEiPS51168. CHORISMATE_MUT_2. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8EH68-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEKTTSELE HLRGLIDGVD QQLLHLLRKR LDLVAQVGTV KHAAGLPIYA
60 70 80 90 100
PQREAAMLAK RREEAQTMGI APQLIEDILR RLMRESYLNE KDVGFKQVKN
110 120 130 140 150
DLGSVVIVGG KGQLGGLFQQ MLRLSGYQVK VLDKDDWQQA ECLFADAGLV
160 170 180 190 200
LVTVPIAITC DIIREKLTQL PRDCILADLT SIKTEPMQAM LAAHKGPVVG
210 220 230 240 250
FHPMFGPDVG SLAKQVVVVC HGREADKYQW LLEQIAIWGA RIVEAEPECH
260 270 280 290 300
DNAMQLVQAM RHFSTFVYGL NLCKEEADIE TLLKFSSPIY RLELAMVGRL
310 320 330 340 350
FAQSPELYAD IIFAQQESQH AIGDYLDNYR EALELLKRGD REEFINQFQM
360 370
VAKWFGDFAP QFQRESRMML QSVSDMKTN
Length:379
Mass (Da):42,876
Last modified:March 1, 2003 - v1
Checksum:iF999D5BDAFD50AB7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN54427.1.
RefSeqiNP_716982.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN54427; AAN54427; SO_1362.
GeneIDi1169183.
KEGGison:SO_1362.
PATRICi23522378. VBISheOne101494_1311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN54427.1 .
RefSeqi NP_716982.1. NC_004347.2.

3D structure databases

ProteinModelPortali Q8EH68.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 211586.SO_1362.

Protocols and materials databases

DNASUi 1169183.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN54427 ; AAN54427 ; SO_1362 .
GeneIDi 1169183.
KEGGi son:SO_1362.
PATRICi 23522378. VBISheOne101494_1311.

Phylogenomic databases

eggNOGi COG0287.
HOGENOMi HOG000275725.
KOi K14187.
OMAi QANDSRQ.
OrthoDBi EOG618R0Z.
PhylomeDBi Q8EH68.

Enzyme and pathway databases

UniPathwayi UPA00120 ; UER00203 .
UPA00122 ; UER00961 .

Family and domain databases

Gene3Di 1.20.59.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR008244. Chor_mut/prephenate_DH_T.
IPR002701. Chorismate_mutase.
IPR020822. Chorismate_mutase_type_II.
IPR011277. CM_T.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view ]
Pfami PF01817. CM_2. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
SMARTi SM00830. CM_2. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
SSF48600. SSF48600. 1 hit.
TIGRFAMsi TIGR01799. CM_T. 1 hit.
PROSITEi PS51168. CHORISMATE_MUT_2. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1.

Entry informationi

Entry nameiTYRA_SHEON
AccessioniPrimary (citable) accession number: Q8EH68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3