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Protein

T-protein

Gene

tyrA

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Chorismate = prephenate.
Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi: L-tyrosine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route).
Proteins known to be involved in this subpathway in this organism are:
  1. T-protein (tyrA)
This subpathway is part of the pathway L-tyrosine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route), the pathway L-tyrosine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: prephenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes prephenate from chorismate.
Proteins known to be involved in this subpathway in this organism are:
  1. T-protein (tyrA)
This subpathway is part of the pathway prephenate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes prephenate from chorismate, the pathway prephenate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

  • chorismate mutase activity Source: TIGR
  • NAD+ binding Source: GO_Central
  • prephenate dehydrogenase (NAD+) activity Source: TIGR
  • prephenate dehydrogenase (NADP+) activity Source: InterPro

GO - Biological processi

  • chorismate metabolic process Source: InterPro
  • oxidation-reduction process Source: GO_Central
  • tyrosine biosynthetic process Source: TIGR

Keywordsi

Molecular functionIsomerase, Oxidoreductase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00120; UER00203.
UPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
T-protein
Including the following 2 domains:
Chorismate mutase (EC:5.4.99.5)
Short name:
CM
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:SO_1362
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003981771 – 379T-proteinAdd BLAST379

Proteomic databases

PaxDbiQ8EH68.

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_1362.

Structurei

3D structure databases

ProteinModelPortaliQ8EH68.
SMRiQ8EH68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 94Chorismate mutasePROSITE-ProRule annotationAdd BLAST92
Domaini103 – 366Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd BLAST264

Sequence similaritiesi

In the C-terminal section; belongs to the prephenate/arogenate dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105EHE. Bacteria.
COG0287. LUCA.
COG1605. LUCA.
HOGENOMiHOG000275725.
KOiK14187.
OMAiQIQIWGA.
OrthoDBiPOG091H01HL.
PhylomeDBiQ8EH68.

Family and domain databases

Gene3Di1.20.59.10. 1 hit.
InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH-like_C_sf.
IPR008244. Chor_mut/prephenate_DH_T.
IPR036263. Chorismate_II_sf.
IPR036979. CM_II_dom_sf.
IPR002701. CM_II_prokaryot.
IPR011277. CM_T.
IPR036291. NAD(P)-bd_dom_sf.
IPR003099. Prephen_DH.
PfamiView protein in Pfam
PF01817. CM_2. 1 hit.
PF02153. PDH. 1 hit.
PIRSFiPIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
SMARTiView protein in SMART
SM00830. CM_2. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF48600. SSF48600. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01799. CM_T. 1 hit.
PROSITEiView protein in PROSITE
PS51168. CHORISMATE_MUT_2. 1 hit.
PS51176. PDH_ADH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8EH68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEKTTSELE HLRGLIDGVD QQLLHLLRKR LDLVAQVGTV KHAAGLPIYA
60 70 80 90 100
PQREAAMLAK RREEAQTMGI APQLIEDILR RLMRESYLNE KDVGFKQVKN
110 120 130 140 150
DLGSVVIVGG KGQLGGLFQQ MLRLSGYQVK VLDKDDWQQA ECLFADAGLV
160 170 180 190 200
LVTVPIAITC DIIREKLTQL PRDCILADLT SIKTEPMQAM LAAHKGPVVG
210 220 230 240 250
FHPMFGPDVG SLAKQVVVVC HGREADKYQW LLEQIAIWGA RIVEAEPECH
260 270 280 290 300
DNAMQLVQAM RHFSTFVYGL NLCKEEADIE TLLKFSSPIY RLELAMVGRL
310 320 330 340 350
FAQSPELYAD IIFAQQESQH AIGDYLDNYR EALELLKRGD REEFINQFQM
360 370
VAKWFGDFAP QFQRESRMML QSVSDMKTN
Length:379
Mass (Da):42,876
Last modified:March 1, 2003 - v1
Checksum:iF999D5BDAFD50AB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA. Translation: AAN54427.1.
RefSeqiNP_716982.1. NC_004347.2.
WP_011071570.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN54427; AAN54427; SO_1362.
GeneIDi1169183.
KEGGison:SO_1362.
PATRICifig|1028802.3.peg.19.

Similar proteinsi

Entry informationi

Entry nameiTYRA_SHEON
AccessioniPrimary (citable) accession number: Q8EH68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families