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Q8EH68

- TYRA_SHEON

UniProt

Q8EH68 - TYRA_SHEON

Protein

T-protein

Gene

tyrA

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Chorismate = prephenate.
    Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

    Pathwayi

    GO - Molecular functioni

    1. chorismate mutase activity Source: UniProtKB-EC
    2. prephenate dehydrogenase (NADP+) activity Source: InterPro
    3. prephenate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. chorismate metabolic process Source: InterPro
    2. tyrosine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase, Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00120; UER00203.
    UPA00122; UER00961.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-protein
    Including the following 2 domains:
    Chorismate mutase (EC:5.4.99.5)
    Short name:
    CM
    Prephenate dehydrogenase (EC:1.3.1.12)
    Short name:
    PDH
    Gene namesi
    Name:tyrA
    Ordered Locus Names:SO_1362
    OrganismiShewanella oneidensis (strain MR-1)
    Taxonomic identifieri211586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000008186: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379T-proteinPRO_0000398177Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi211586.SO_1362.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8EH68.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 9492Chorismate mutasePROSITE-ProRule annotationAdd
    BLAST
    Domaini103 – 366264Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 chorismate mutase domain.PROSITE-ProRule annotation
    Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0287.
    HOGENOMiHOG000275725.
    KOiK14187.
    OMAiQANDSRQ.
    OrthoDBiEOG618R0Z.
    PhylomeDBiQ8EH68.

    Family and domain databases

    Gene3Di1.20.59.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR008244. Chor_mut/prephenate_DH_T.
    IPR002701. Chorismate_mutase.
    IPR020822. Chorismate_mutase_type_II.
    IPR011277. CM_T.
    IPR016040. NAD(P)-bd_dom.
    IPR003099. Prephen_DH.
    [Graphical view]
    PfamiPF01817. CM_2. 1 hit.
    PF02153. PDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
    SMARTiSM00830. CM_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    SSF48600. SSF48600. 1 hit.
    TIGRFAMsiTIGR01799. CM_T. 1 hit.
    PROSITEiPS51168. CHORISMATE_MUT_2. 1 hit.
    PS51176. PDH_ADH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8EH68-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNEKTTSELE HLRGLIDGVD QQLLHLLRKR LDLVAQVGTV KHAAGLPIYA    50
    PQREAAMLAK RREEAQTMGI APQLIEDILR RLMRESYLNE KDVGFKQVKN 100
    DLGSVVIVGG KGQLGGLFQQ MLRLSGYQVK VLDKDDWQQA ECLFADAGLV 150
    LVTVPIAITC DIIREKLTQL PRDCILADLT SIKTEPMQAM LAAHKGPVVG 200
    FHPMFGPDVG SLAKQVVVVC HGREADKYQW LLEQIAIWGA RIVEAEPECH 250
    DNAMQLVQAM RHFSTFVYGL NLCKEEADIE TLLKFSSPIY RLELAMVGRL 300
    FAQSPELYAD IIFAQQESQH AIGDYLDNYR EALELLKRGD REEFINQFQM 350
    VAKWFGDFAP QFQRESRMML QSVSDMKTN 379
    Length:379
    Mass (Da):42,876
    Last modified:March 1, 2003 - v1
    Checksum:iF999D5BDAFD50AB7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN54427.1.
    RefSeqiNP_716982.1. NC_004347.2.

    Genome annotation databases

    EnsemblBacteriaiAAN54427; AAN54427; SO_1362.
    GeneIDi1169183.
    KEGGison:SO_1362.
    PATRICi23522378. VBISheOne101494_1311.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN54427.1 .
    RefSeqi NP_716982.1. NC_004347.2.

    3D structure databases

    ProteinModelPortali Q8EH68.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 211586.SO_1362.

    Protocols and materials databases

    DNASUi 1169183.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN54427 ; AAN54427 ; SO_1362 .
    GeneIDi 1169183.
    KEGGi son:SO_1362.
    PATRICi 23522378. VBISheOne101494_1311.

    Phylogenomic databases

    eggNOGi COG0287.
    HOGENOMi HOG000275725.
    KOi K14187.
    OMAi QANDSRQ.
    OrthoDBi EOG618R0Z.
    PhylomeDBi Q8EH68.

    Enzyme and pathway databases

    UniPathwayi UPA00120 ; UER00203 .
    UPA00122 ; UER00961 .

    Family and domain databases

    Gene3Di 1.20.59.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR008244. Chor_mut/prephenate_DH_T.
    IPR002701. Chorismate_mutase.
    IPR020822. Chorismate_mutase_type_II.
    IPR011277. CM_T.
    IPR016040. NAD(P)-bd_dom.
    IPR003099. Prephen_DH.
    [Graphical view ]
    Pfami PF01817. CM_2. 1 hit.
    PF02153. PDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
    SMARTi SM00830. CM_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    SSF48600. SSF48600. 1 hit.
    TIGRFAMsi TIGR01799. CM_T. 1 hit.
    PROSITEi PS51168. CHORISMATE_MUT_2. 1 hit.
    PS51176. PDH_ADH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MR-1.

    Entry informationi

    Entry nameiTYRA_SHEON
    AccessioniPrimary (citable) accession number: Q8EH68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3