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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPolyamine biosynthesis, Spermidine biosynthesis
LigandMagnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSONE211586:G1GMP-1726-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:SO_1870
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499771 – 637Biosynthetic arginine decarboxylaseAdd BLAST637

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei101N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiQ8EFU5

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_1870

Structurei

3D structure databases

ProteinModelPortaliQ8EFU5
SMRiQ8EFU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni286 – 296Substrate-bindingUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DP5 Bacteria
COG1166 LUCA
HOGENOMiHOG000029191
KOiK01585
OMAiLFPIMPI
OrthoDBiPOG091H04NG
PhylomeDBiQ8EFU5

Family and domain databases

CDDicd06830 PLPDE_III_ADC, 1 hit
Gene3Di2.40.37.10, 3 hits
3.20.20.10, 1 hit
HAMAPiMF_01417 SpeA, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002985 Arg_decrbxlase
IPR022644 De-COase2_N
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43295 PTHR43295, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PIRSFiPIRSF001336 Arg_decrbxlase, 1 hit
PRINTSiPR01180 ARGDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01273 speA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8EFU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDWSIEAAR AGYNVTHWSQ GFYGISDEGE VTVSPDPKNP DHKIGLNELA
60 70 80 90 100
KDMVKAGVAL PVLVRFPQIL HHRVNSLCQA FDQAIQKYEY QADYLLVYPI
110 120 130 140 150
KVNQQKTVVE EILASQASKE VPQLGLEAGS KPELMAVLAM AQKASSVIVC
160 170 180 190 200
NGYKDNEYIR LALIGEKLGH KVYIVLEKLS ELKMVLAESK RLGVKPRLGL
210 220 230 240 250
RARLAFQGKG KWQASGGEKS KFGLSAAQIL TVVDQLKQSD MLDSLQLLHF
260 270 280 290 300
HLGSQIANIR DIRQGVSEAA RFYCELRELG ASINCFDVGG GLAVDYDGTR
310 320 330 340 350
SQSNNSMNYG LSEYANNIVN VLTDICNEYE QPMPRIISES GRHLTAHHAV
360 370 380 390 400
LITDVIGTEA YQVEDIQPPE EESPQLLHNM WQSWTELSGR ADQRALIEIY
410 420 430 440 450
HDSQSDLQEA QSLFALGQLS LAERAWAEQA NLRVCHEVQG LLSTKNRYHR
460 470 480 490 500
PIIDELNEKL ADKFFVNFSL FQSLPDAWGI DQVFPVLPLS GLDKAPERRA
510 520 530 540 550
VMLDITCDSD GIVDQYVDGQ GIETTLPVPA WSAESPYLIG FFMVGAYQEI
560 570 580 590 600
LGDMHNLFGD TNSAVVSIEE NGMTNIESVL AGDTVADVLR YVNLDAVDFM
610 620 630
RTYEELVNQH IAEDERAQIL EELQVGLKGY TYLEDFS
Length:637
Mass (Da):71,004
Last modified:March 1, 2003 - v1
Checksum:i8EAE2CF59061F7B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA Translation: AAN54922.1
RefSeqiNP_717478.1, NC_004347.2
WP_011071982.1, NC_004347.2

Genome annotation databases

EnsemblBacteriaiAAN54922; AAN54922; SO_1870
GeneIDi1169637
KEGGison:SO_1870
PATRICifig|211586.12.peg.1798

Similar proteinsi

Entry informationi

Entry nameiSPEA_SHEON
AccessioniPrimary (citable) accession number: Q8EFU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health