Q8EFF4 (HEMH1_SHEON) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferrochelatase 1
EC=4.99.1.1

Alternative name(s):
Heme synthase 1
Protoheme ferro-lyase 1

Gene names

Name:	hemH1
Synonyms:	hemH-1
Ordered Locus Names:	SO_2019

Organism

Shewanella oneidensis

Taxonomic identifier

70863 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity HAMAP MF_00323.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Ferrochelatase 1 HAMAP MF_00323		PRO_0000175198
Sites
	Metal binding	215	1	Iron By similarity
	Metal binding	296	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8EFF4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: D62FE9874C77E5C4	FASTA	348	38,883
	10 20 30 40 50 60 MLACRGIWLI KGSTLTSPSP AFGVLLVNLG TPDEPTPKAV KRFLKQFLSD PRVVDLSPWL 70 80 90 100 110 120 WQPILQGIIL NTRPKKVAKL YQSVWTEQGS PLMVISQCQA QKLATDLSAT FNQTIPVELG 130 140 150 160 170 180 MSYGNPSIES GFAKLKAQGA ERIVVLPLYP QYSCSTVASV FDAVAHYLTR VRDIPELRFN 190 200 210 220 230 240 KQYFAHEAYI AALAHSVKRH WKTHGQAEKL ILSFHGIPLR YATEGDPYPE QCRTTAKLLA 250 260 270 280 290 300 QALGLTDGQW QVCFQSRFGK EEWLTPYADE LLADLPRQGV KSVDVICPAF ATDCLETLEE 310 320 330 340 ISIGAKETFL HAGGEAYHFI PCLNDDELHI ELLRLLVQEQ TQSWISAE

References

[1]

"Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis." Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C., Read T.D., Eisen J.A., Seshadri R., Ward N.L., Methe B.A., Clayton R.A., Meyer T., Tsapin A., Scott J., Beanan M.J., Brinkac L.M., Daugherty S.C., DeBoy R.T. , Dodson R.J., Durkin A.S., Haft D.H., Kolonay J.F., Madupu R., Peterson J.D., Umayam L.A., White O., Wolf A.M., Vamathevan J.J., Weidman J.F., Impraim M., Lee K., Berry K.J., Lee C., Mueller J., Khouri H.M., Gill J., Utterback T.R., McDonald L.A., Feldblyum T.V., Smith H.O., Venter J.C., Nealson K.H., Fraser C.M. Nat. Biotechnol. 20:1118-1123(2002) [PubMed: 12368813] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MR-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014299 Genomic DNA. Translation: AAN55069.1.
RefSeq	NP_717625.1. NC_004347.1.
3D structure databases
ProteinModelPortal	Q8EFF4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1169771.
GenomeReviews	Gene locus SO_2019 in contig AE014299_GR.
KEGG	son:SO_2019.
NMPDR	fig|211586.1.peg.1840.
PATRIC	23523659. VBISheOne101494_1938.
TIGR	SO_2019.
Phylogenomic databases
HOGENOM	HBG697135.
OMA	TIEEIGM.
ProtClustDB	CLSK906551.
Enzyme and pathway databases
BioCyc	SONE211586:SO_2019-MONOMER.
Family and domain databases
HAMAP	MF_00323. Ferrochelatase. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
KO	K01772.
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00109. HemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH1_SHEON

Accession

Primary (citable) accession number: Q8EFF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program