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Q8EFB1 (HISX_SHEON) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:SO_2073
OrganismShewanella oneidensis (strain MR-1) [Reference proteome] [HAMAP]
Taxonomic identifier211586 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 438438Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135841

Sites

Active site3321Proton acceptor By similarity
Active site3331Proton acceptor By similarity
Metal binding2651Zinc By similarity
Metal binding2681Zinc By similarity
Metal binding3661Zinc By similarity
Metal binding4251Zinc By similarity
Binding site1351NAD By similarity
Binding site1931NAD By similarity
Binding site2161NAD By similarity
Binding site2431Substrate By similarity
Binding site2651Substrate By similarity
Binding site2681Substrate By similarity
Binding site3331Substrate By similarity
Binding site3661Substrate By similarity
Binding site4201Substrate By similarity
Binding site4251Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8EFB1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: D7D034A1C45AFBE3

FASTA43846,297
        10         20         30         40         50         60 
MDMLTWAALS ADEQKTALQR SPLIGDSGLE QSVRAIVDAV ASRGDAAIKE FNQKFDGARL 

        70         80         90        100        110        120 
ANISSANSDN LRLSEHEIEA ASARVSPELK AAIAQAMANI DVFHSAQQFR PIDIETQAGV 

       130        140        150        160        170        180 
RCELRSEPIE KVGLYIPGGS APLISTVLML ALPATIAGCE QRVLVSPPPI NDAIVYAANV 

       190        200        210        220        230        240 
CGITEIYQVG GAQAIAALAF GTETIPSVDK IFGPGNRYVT EAKRLVSQDG RCTVSIDMPA 

       250        260        270        280        290        300 
GPSEVLVIAD SDANAQFIAA DLLSQAEHGP DSQVILVTDS LPLAQAVNQA LKSQLAALPR 

       310        320        330        340        350        360 
QEIAATALKG SRTILVKDMQ EAALVSNRYG PEHLIIQTRF PREVLNNIRA AGSVFLGAYT 

       370        380        390        400        410        420 
PESVGDYASG TNHVLPTYGY SRAVSSLSLA DFSRRFTVQE LSAKGLLGLG QAVMTLASNE 

       430 
LLDAHKNAVA VRLASLKG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014299 Genomic DNA. Translation: AAN55120.1.
RefSeqNP_717676.1. NC_004347.2.

3D structure databases

ProteinModelPortalQ8EFB1.
SMRQ8EFB1. Positions 2-437.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING211586.SO_2073.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN55120; AAN55120; SO_2073.
GeneID1169818.
KEGGson:SO_2073.
PATRIC23523768. VBISheOne101494_1991.

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAPSEILII.
OrthoDBEOG6CVVCR.
ProtClustDBPRK00877.

Enzyme and pathway databases

UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_SHEON
AccessionPrimary (citable) accession number: Q8EFB1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways