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Q8EFB1

- HISX_SHEON

UniProt

Q8EFB1 - HISX_SHEON

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Protein

Histidinol dehydrogenase

Gene
hisD, SO_2073
Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351NAD By similarity
Binding sitei193 – 1931NAD By similarity
Binding sitei216 – 2161NAD By similarity
Binding sitei243 – 2431Substrate By similarity
Metal bindingi265 – 2651Zinc By similarity
Binding sitei265 – 2651Substrate By similarity
Metal bindingi268 – 2681Zinc By similarity
Binding sitei268 – 2681Substrate By similarity
Active sitei332 – 3321Proton acceptor By similarity
Active sitei333 – 3331Proton acceptor By similarity
Binding sitei333 – 3331Substrate By similarity
Metal bindingi366 – 3661Zinc By similarity
Binding sitei366 – 3661Substrate By similarity
Binding sitei420 – 4201Substrate By similarity
Metal bindingi425 – 4251Zinc By similarity
Binding sitei425 – 4251Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:SO_2073
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Histidinol dehydrogenaseUniRule annotationPRO_0000135841Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_2073.

Structurei

3D structure databases

ProteinModelPortaliQ8EFB1.
SMRiQ8EFB1. Positions 2-437.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ8EFB1.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8EFB1-1 [UniParc]FASTAAdd to Basket

« Hide

MDMLTWAALS ADEQKTALQR SPLIGDSGLE QSVRAIVDAV ASRGDAAIKE    50
FNQKFDGARL ANISSANSDN LRLSEHEIEA ASARVSPELK AAIAQAMANI 100
DVFHSAQQFR PIDIETQAGV RCELRSEPIE KVGLYIPGGS APLISTVLML 150
ALPATIAGCE QRVLVSPPPI NDAIVYAANV CGITEIYQVG GAQAIAALAF 200
GTETIPSVDK IFGPGNRYVT EAKRLVSQDG RCTVSIDMPA GPSEVLVIAD 250
SDANAQFIAA DLLSQAEHGP DSQVILVTDS LPLAQAVNQA LKSQLAALPR 300
QEIAATALKG SRTILVKDMQ EAALVSNRYG PEHLIIQTRF PREVLNNIRA 350
AGSVFLGAYT PESVGDYASG TNHVLPTYGY SRAVSSLSLA DFSRRFTVQE 400
LSAKGLLGLG QAVMTLASNE LLDAHKNAVA VRLASLKG 438
Length:438
Mass (Da):46,297
Last modified:March 1, 2003 - v1
Checksum:iD7D034A1C45AFBE3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN55120.1.
RefSeqiNP_717676.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN55120; AAN55120; SO_2073.
GeneIDi1169818.
KEGGison:SO_2073.
PATRICi23523768. VBISheOne101494_1991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014299 Genomic DNA. Translation: AAN55120.1 .
RefSeqi NP_717676.1. NC_004347.2.

3D structure databases

ProteinModelPortali Q8EFB1.
SMRi Q8EFB1. Positions 2-437.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 211586.SO_2073.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN55120 ; AAN55120 ; SO_2073 .
GeneIDi 1169818.
KEGGi son:SO_2073.
PATRICi 23523768. VBISheOne101494_1991.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.
PhylomeDBi Q8EFB1.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1.

Entry informationi

Entry nameiHISX_SHEON
AccessioniPrimary (citable) accession number: Q8EFB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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