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Q8EEW2

- NAGZ_SHEON

UniProt

Q8EEW2 - NAGZ_SHEON

Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

    Catalytic activityi

    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei61 – 611SubstrateUniRule annotation
    Binding sitei69 – 691SubstrateUniRule annotation
    Binding sitei134 – 1341SubstrateUniRule annotation
    Sitei175 – 1751Important for catalytic activityUniRule annotation
    Active sitei177 – 1771Proton donor/acceptorUniRule annotation
    Active sitei249 – 2491NucleophileUniRule annotation

    GO - Molecular functioni

    1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cell cycle Source: UniProtKB-KW
    3. cell division Source: UniProtKB-KW
    4. peptidoglycan biosynthetic process Source: UniProtKB-KW
    5. peptidoglycan turnover Source: UniProtKB-HAMAP
    6. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    UniPathwayiUPA00544.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
    Alternative name(s):
    Beta-N-acetylhexosaminidaseUniRule annotation
    N-acetyl-beta-glucosaminidaseUniRule annotation
    Gene namesi
    Name:nagZUniRule annotation
    Ordered Locus Names:SO_2250
    OrganismiShewanella oneidensis (strain MR-1)
    Taxonomic identifieri211586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000008186: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Beta-hexosaminidasePRO_0000210798Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi211586.SO_2250.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8EEW2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni164 – 1652Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1472.
    HOGENOMiHOG000248526.
    KOiK01207.
    OMAiLLNGFVW.
    OrthoDBiEOG6BCT06.
    PhylomeDBiQ8EEW2.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    HAMAPiMF_00364. NagZ.
    InterProiIPR022956. Beta_hexosaminidase_bac.
    IPR019800. Glyco_hydro_3_AS.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00933. Glyco_hydro_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8EEW2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYLMLDLLS LDVSEAEAEM LRHPQVGGLI LFSRNFTSRE QLIALVQQIR    50
    QIRPEILIAV DHEGGRVQRF REGFTLIPAM GDILPAAKGD MALAKRWACE 100
    LGFLMAIELL ACDIDLSFAP VLDLNGISQV IGKRSFSANP DEVIALARSF 150
    IEGMAQAGMG AVGKHFPGHG SVAADSHIAQ PIDEREGEVI FNQDILPFKE 200
    LIFNGKLSGI MPAHVIYPKV DPNPAGFSSY WLKQILRKEL GFNGVIFSDD 250
    LGMKGASFAG DYVGRAKAAL DAGCDMILVC NDNPGVMTLL NGFVWPEAAP 300
    QHPASLLKPN MAQTALALEN SARWENAKQL AEQIQLAQQA KV 342
    Length:342
    Mass (Da):37,193
    Last modified:March 1, 2003 - v1
    Checksum:iAB603E9104D16065
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN55290.1.
    RefSeqiNP_717846.1. NC_004347.2.

    Genome annotation databases

    EnsemblBacteriaiAAN55290; AAN55290; SO_2250.
    GeneIDi1169981.
    KEGGison:SO_2250.
    PATRICi23524121. VBISheOne101494_2166.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN55290.1 .
    RefSeqi NP_717846.1. NC_004347.2.

    3D structure databases

    ProteinModelPortali Q8EEW2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 211586.SO_2250.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN55290 ; AAN55290 ; SO_2250 .
    GeneIDi 1169981.
    KEGGi son:SO_2250.
    PATRICi 23524121. VBISheOne101494_2166.

    Phylogenomic databases

    eggNOGi COG1472.
    HOGENOMi HOG000248526.
    KOi K01207.
    OMAi LLNGFVW.
    OrthoDBi EOG6BCT06.
    PhylomeDBi Q8EEW2.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    HAMAPi MF_00364. NagZ.
    InterProi IPR022956. Beta_hexosaminidase_bac.
    IPR019800. Glyco_hydro_3_AS.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00933. Glyco_hydro_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MR-1.

    Entry informationi

    Entry nameiNAGZ_SHEON
    AccessioniPrimary (citable) accession number: Q8EEW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3