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Protein

dCTP deaminase

Gene

dcd

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei128dCTPUniRule annotation1
Active sitei138Proton donor/acceptorUniRule annotation1
Binding sitei171dCTPUniRule annotation1
Binding sitei178dCTPUniRule annotation1
Binding sitei182dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi110 – 115dCTP bindingUniRule annotation6
Nucleotide bindingi136 – 138dCTP bindingUniRule annotation3

GO - Molecular functioni

  • dCTP deaminase activity Source: TIGR

GO - Biological processi

  • dCTP catabolic process Source: TIGR
  • dUMP biosynthetic process Source: UniProtKB-UniPathway
  • dUTP biosynthetic process Source: InterPro

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciSONE211586:G1GMP-2402-MONOMER
UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:SO_2616
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560121 – 193dCTP deaminaseAdd BLAST193

Proteomic databases

PaxDbiQ8EDX5

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi211586.SO_2616

Structurei

3D structure databases

ProteinModelPortaliQ8EDX5
SMRiQ8EDX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP Bacteria
COG0717 LUCA
HOGENOMiHOG000228601
KOiK01494
OMAiGWIDAGF
OrthoDBiPOG091H015O
PhylomeDBiQ8EDX5

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

Q8EDX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLTDIEIEQ ALDNGTIVIE PRPNNDAISG VSVDVRLGGQ FRVFKDHTAP
60 70 80 90 100
FIDLSGPSGE VQAALDRVMS EIIEIPDGEA FFLHPGELAL AVTYESVTLP
110 120 130 140 150
ADIVGWLDGR SSLARLGLMV HVTAHRIDPG WQGKIVLEFY NSGKLPLALR
160 170 180 190
PRMTIGALNF ERLSGPVARP YNKRKNAKYK DQQDAVASRI SQD
Length:193
Mass (Da):21,218
Last modified:March 1, 2003 - v1
Checksum:i1EF41BA888681B1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA Translation: AAN55645.1
RefSeqiNP_718201.1, NC_004347.2
WP_011072565.1, NC_004347.2

Genome annotation databases

EnsemblBacteriaiAAN55645; AAN55645; SO_2616
GeneIDi1170318
KEGGison:SO_2616
PATRICifig|211586.12.peg.2519

Similar proteinsi

Entry informationi

Entry nameiDCD_SHEON
AccessioniPrimary (citable) accession number: Q8EDX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health