Q8EDW2 (Q8EDW2_SHEON) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase NADP-dependent Icd EMBL AAN55658.1
EC=1.1.1.42 EMBL AAN55658.1

Gene names

Name:	icd EMBL AAN55658.1
Ordered Locus Names:	SO_2629 EMBL AAN55658.1

Organism

Shewanella oneidensis (strain MR-1) [Reference proteome] [HAMAP] EMBL AAN55658.1

Taxonomic identifier

211586 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella › Shewanella oneidensis

Protein attributes

Sequence length	741 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Molecular function	Oxidoreductase EMBL AAN55658.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	134 – 141	8	Substrate binding By similarity PIRSR PIRSR009407-2
Sites
	Metal binding	352	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	550	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	554	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	147	1	Substrate By similarity PIRSR PIRSR009407-2
	Binding site	549	1	Substrate By similarity PIRSR PIRSR009407-2
	Site	257	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	422	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	Q8EDW2 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: A9F17C40A617ECE7	FASTA	741	80,501
	10 20 30 40 50 60 MKDNSPTIIY TETDEAPALA TLSLLPIIKT FTNAADVAVE TRDISLSGRV IANFPEKLTD 70 80 90 100 110 120 AQKIGDHLAE LGDLANQPEA NIIKLPNISA SIPQLKACIL ELQQKGYDIP NYPDEPKTDE 130 140 150 160 170 180 EKSIKARYDK IKGSAVNPVL REGNSDRRAP LSVKNFAKKN PHSMGKWVKD SKSHVAHMSE 190 200 210 220 230 240 GDFYGSELSV TLSNADTVNI VLAQKDGQEV VLKSGLKLLA GEIIDASVMS KKALVSFFER 250 260 270 280 290 300 EIANAKAENV LLSLHLKATM MKVSDPIMFG HAVKVFFKPV FDKHAALFAE LGVDVNNGFG 310 320 330 340 350 360 DVYAKIASLP TDVRSQIEAD IAAVYAEGPA LAMVDSDKGI TNLHVPSDII IDASMPAAIR 370 380 390 400 410 420 SSGQMWGPDG KLHDTKALIP DRCYAGVYQE TIAFCKEHGA FDPSTMGSVP NVGLMAQKAE 430 440 450 460 470 480 EYGSHDKTFE IPADGVVNVI DASGKVLMSH NVEAGDIWRM CQVKDAPIRD WVKLAVRRAR 490 500 510 520 530 540 LSNTPAVFWL DANRAHDAQL IVKVKQYLPE HDTSGLDISI MSPEEATRFS LARIKEGKDT 550 560 570 580 590 600 ISVTGNVLRD YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQVEKEGH 610 620 630 640 650 660 LRWDSLGEFL ALAASLEHLS QTVGNPKAQV LADTLDQAIG QFLDSNKSPS RRVGELDNRG 670 680 690 700 710 720 SHFYLAMYWA QALAVQTKDE QLQAHFIPLA HALSANEQVI VAELNNAQGA PVDLGGYYRL 730 740 DAVKAEKAMR PSETLNKLLI A

References

[1]

"Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis." Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C., Read T.D., Eisen J.A., Seshadri R., Ward N.L., Methe B.A., Clayton R.A., Meyer T., Tsapin A., Scott J., Beanan M.J., Brinkac L.M., Daugherty S.C., DeBoy R.T. , Dodson R.J., Durkin A.S., Haft D.H., Kolonay J.F., Madupu R., Peterson J.D., Umayam L.A., White O., Wolf A.M., Vamathevan J.J., Weidman J.F., Impraim M., Lee K., Berry K.J., Lee C., Mueller J., Khouri H.M., Gill J., Utterback T.R., McDonald L.A., Feldblyum T.V., Smith H.O., Venter J.C., Nealson K.H., Fraser C.M. Nat. Biotechnol. 20:1118-1123(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MR-1 EMBL AAN55658.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014299 Genomic DNA. Translation: AAN55658.1.
RefSeq	NP_718214.1. NC_004347.2.
3D structure databases
HSSP	HSSP built from PDB template 1J1W based on UniProtKB P16100.
ProteinModelPortal	Q8EDW2.
SMR	Q8EDW2. Positions 5-739.
ModBase	Search...
Protein-protein interaction databases
STRING	211586.SO_2629.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN55658; AAN55658; SO_2629.
GeneID	1170331.
KEGG	son:SO_2629.
PATRIC	23524885. VBISheOne101494_2532.
Phylogenomic databases
HOGENOM	HOG000240860.
KO	K00031.
OMA	FRMCQTK.
ProtClustDB	CLSK867411.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8EDW2_SHEON

Accession

Primary (citable) accession number: Q8EDW2

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)