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Q8EDW2

- Q8EDW2_SHEON

UniProt

Q8EDW2 - Q8EDW2_SHEON

Protein
Submitted name:

Isocitrate dehydrogenase NADP-dependent Icd

Gene

icd

Organism
Shewanella oneidensis (strain MR-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471SubstrateUniRule annotation
    Sitei257 – 2571Critical for catalysisUniRule annotation
    Metal bindingi352 – 3521Magnesium or manganese
    Sitei422 – 4221Critical for catalysisUniRule annotation
    Binding sitei549 – 5491SubstrateUniRule annotation
    Metal bindingi550 – 5501Magnesium or manganese
    Metal bindingi554 – 5541Magnesium or manganese

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase NADP-dependent IcdImported (EC:1.1.1.42Imported)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:SO_2629Imported
    OrganismiShewanella oneidensis (strain MR-1)Imported
    Taxonomic identifieri211586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000008186: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi211586.SO_2629.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8EDW2.
    SMRiQ8EDW2. Positions 5-739.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate bindingUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiEEQRIGD.
    OrthoDBiEOG6DVJPP.
    PhylomeDBiQ8EDW2.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8EDW2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDNSPTIIY TETDEAPALA TLSLLPIIKT FTNAADVAVE TRDISLSGRV    50
    IANFPEKLTD AQKIGDHLAE LGDLANQPEA NIIKLPNISA SIPQLKACIL 100
    ELQQKGYDIP NYPDEPKTDE EKSIKARYDK IKGSAVNPVL REGNSDRRAP 150
    LSVKNFAKKN PHSMGKWVKD SKSHVAHMSE GDFYGSELSV TLSNADTVNI 200
    VLAQKDGQEV VLKSGLKLLA GEIIDASVMS KKALVSFFER EIANAKAENV 250
    LLSLHLKATM MKVSDPIMFG HAVKVFFKPV FDKHAALFAE LGVDVNNGFG 300
    DVYAKIASLP TDVRSQIEAD IAAVYAEGPA LAMVDSDKGI TNLHVPSDII 350
    IDASMPAAIR SSGQMWGPDG KLHDTKALIP DRCYAGVYQE TIAFCKEHGA 400
    FDPSTMGSVP NVGLMAQKAE EYGSHDKTFE IPADGVVNVI DASGKVLMSH 450
    NVEAGDIWRM CQVKDAPIRD WVKLAVRRAR LSNTPAVFWL DANRAHDAQL 500
    IVKVKQYLPE HDTSGLDISI MSPEEATRFS LARIKEGKDT ISVTGNVLRD 550
    YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQVEKEGH 600
    LRWDSLGEFL ALAASLEHLS QTVGNPKAQV LADTLDQAIG QFLDSNKSPS 650
    RRVGELDNRG SHFYLAMYWA QALAVQTKDE QLQAHFIPLA HALSANEQVI 700
    VAELNNAQGA PVDLGGYYRL DAVKAEKAMR PSETLNKLLI A 741
    Length:741
    Mass (Da):80,501
    Last modified:March 1, 2003 - v1
    Checksum:iA9F17C40A617ECE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN55658.1.
    RefSeqiNP_718214.1. NC_004347.2.

    Genome annotation databases

    EnsemblBacteriaiAAN55658; AAN55658; SO_2629.
    GeneIDi1170331.
    KEGGison:SO_2629.
    PATRICi23524885. VBISheOne101494_2532.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014299 Genomic DNA. Translation: AAN55658.1 .
    RefSeqi NP_718214.1. NC_004347.2.

    3D structure databases

    ProteinModelPortali Q8EDW2.
    SMRi Q8EDW2. Positions 5-739.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 211586.SO_2629.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN55658 ; AAN55658 ; SO_2629 .
    GeneIDi 1170331.
    KEGGi son:SO_2629.
    PATRICi 23524885. VBISheOne101494_2532.

    Phylogenomic databases

    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi EEQRIGD.
    OrthoDBi EOG6DVJPP.
    PhylomeDBi Q8EDW2.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MR-1Imported.

    Entry informationi

    Entry nameiQ8EDW2_SHEON
    AccessioniPrimary (citable) accession number: Q8EDW2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3