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Protein
Submitted name:

Isocitrate dehydrogenase NADP-dependent Icd

Gene

icd

Organism
Shewanella oneidensis (strain MR-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei549 – 5491SubstrateUniRule annotation
Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation
Metal bindingi554 – 5541Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase NADP-dependent IcdImported (EC:1.1.1.42Imported)
Gene namesi
Name:icdImported
Ordered Locus Names:SO_2629Imported
OrganismiShewanella oneidensis (strain MR-1)Imported
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000008186 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_2629.

Structurei

3D structure databases

ProteinModelPortaliQ8EDW2.
SMRiQ8EDW2. Positions 5-739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.
PhylomeDBiQ8EDW2.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8EDW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDNSPTIIY TETDEAPALA TLSLLPIIKT FTNAADVAVE TRDISLSGRV
60 70 80 90 100
IANFPEKLTD AQKIGDHLAE LGDLANQPEA NIIKLPNISA SIPQLKACIL
110 120 130 140 150
ELQQKGYDIP NYPDEPKTDE EKSIKARYDK IKGSAVNPVL REGNSDRRAP
160 170 180 190 200
LSVKNFAKKN PHSMGKWVKD SKSHVAHMSE GDFYGSELSV TLSNADTVNI
210 220 230 240 250
VLAQKDGQEV VLKSGLKLLA GEIIDASVMS KKALVSFFER EIANAKAENV
260 270 280 290 300
LLSLHLKATM MKVSDPIMFG HAVKVFFKPV FDKHAALFAE LGVDVNNGFG
310 320 330 340 350
DVYAKIASLP TDVRSQIEAD IAAVYAEGPA LAMVDSDKGI TNLHVPSDII
360 370 380 390 400
IDASMPAAIR SSGQMWGPDG KLHDTKALIP DRCYAGVYQE TIAFCKEHGA
410 420 430 440 450
FDPSTMGSVP NVGLMAQKAE EYGSHDKTFE IPADGVVNVI DASGKVLMSH
460 470 480 490 500
NVEAGDIWRM CQVKDAPIRD WVKLAVRRAR LSNTPAVFWL DANRAHDAQL
510 520 530 540 550
IVKVKQYLPE HDTSGLDISI MSPEEATRFS LARIKEGKDT ISVTGNVLRD
560 570 580 590 600
YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQVEKEGH
610 620 630 640 650
LRWDSLGEFL ALAASLEHLS QTVGNPKAQV LADTLDQAIG QFLDSNKSPS
660 670 680 690 700
RRVGELDNRG SHFYLAMYWA QALAVQTKDE QLQAHFIPLA HALSANEQVI
710 720 730 740
VAELNNAQGA PVDLGGYYRL DAVKAEKAMR PSETLNKLLI A
Length:741
Mass (Da):80,501
Last modified:March 1, 2003 - v1
Checksum:iA9F17C40A617ECE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA. Translation: AAN55658.1.
RefSeqiNP_718214.1. NC_004347.2.
WP_011072577.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN55658; AAN55658; SO_2629.
GeneIDi1170331.
KEGGison:SO_2629.
PATRICi23524885. VBISheOne101494_2532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA. Translation: AAN55658.1.
RefSeqiNP_718214.1. NC_004347.2.
WP_011072577.1. NC_004347.2.

3D structure databases

ProteinModelPortaliQ8EDW2.
SMRiQ8EDW2. Positions 5-739.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi211586.SO_2629.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN55658; AAN55658; SO_2629.
GeneIDi1170331.
KEGGison:SO_2629.
PATRICi23524885. VBISheOne101494_2532.

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.
PhylomeDBiQ8EDW2.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MR-1Imported.

Entry informationi

Entry nameiQ8EDW2_SHEON
AccessioniPrimary (citable) accession number: Q8EDW2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 29, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.